Category: 1752-88-1

Adding a certain compound to certain chemical reactions, such as: 1752-88-1, name is 3-Pyrazolidinone hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1752-88-1, name: 3-Pyrazolidinone hydrochloride

EXAMPLE X31 1-[10-(4-Acetonylphenoxy)decyl]pyrazolidin-3-one. A mixture of 10-(4-acetonylphenoxy)decylbromide, ethylene ketal (3.0 g), potassium carbonate (3.8 g), pyrazolidin-3-one hydrochloride (1.47 g) and potassium iodide (0.5 g) in acetonitrile:water (95:5), was heated under reflux for 3 hr. The reaction mixture was allowed to cool, filtered and the solvent evaporated in vacuo. The residue was dissolved in chloroform, washed with water (2*50 ml), dried (magnesium sulphate), fitered and the solvent removed in vacuo. The residue was dissolved in acetone (50 ml) and treated with 2M hydrochloric acid solution (3 ml) and allowed to stand at room temperature for 3 hr. The solvent was removed in vacuo and the residue was dissolved in chloroform and washed with 1.2M sodium bicarbonate solution (1*50 ml), water (2*50 ml), dried (magnesium sulphate), filtered and the solvent removed in vacuo to give 1-[10-(4-acetonylphenoxy)decyl]pyrazolidin-3-one (0.66 g). 1 H NMR (CDCl3) ppm: 1.1-2.1(16H,m); 2.2(3H,s); 2.3-3.0(4H,m); 3.3(2H,m); 3.7(2H,s); 4.0(2H,m); 7.1(4H,dd); 8.0-92(1H, very broad, exchanges with D2 O).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Pyrazolidinone hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference of 1752-88-1, These common heterocyclic compound, 1752-88-1, name is 3-Pyrazolidinone hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Alkylation of 20 with 21 to give 22 Potassium carbonate (8.28 g, 60.0 mmol), methyl 5-(3-bromopropyl)-thiophene-2-carboxylate (21, for preparation, see Billot, X. et al WO2004/037786, incorporated by reference herein, 5.66 g, 21.5 mmol), 3-pyrazolidinone HCl (20, 2.57 g, 21.0 mmol) and DMF (25 mL) were combined under argon and stirred at rt. After 3 d at rt, HPLC analysis indicated the reaction to be complete and EtOAc (100 mL) was added. The mixture was washed with water (2¡Á75 mL). The combined aqueous phase was back-extracted with EtOAc (50 mL). The combined organic phase was washed with brine (75 mL), filtered through filter paper and concentrated in vacuo to afford 7.5 g of a crude oil. Purification of the crude product by flash column chromatography on 75 g silica gel (50% CH2Cl2/hexane?CH2Cl2?20% EtOAc/CH2Cl2?100% EtOAc?10% MeOH/EtOAc, gradient) afforded 3.2 g (57%) of 22 which solidified on standing.

The synthetic route of 1752-88-1 has been constantly updated, and we look forward to future research findings.