Category: 73387-46-9

Patil, Dayanand et al. published their research in Research on Chemical Intermediates in 2015 | CAS: 73387-46-9

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Product Details of 73387-46-9

Novel crown ether functionalized imidazolium-based acidic ionic liquid catalyzed synthesis of pyrazole derivatives under solvent-free conditions was written by Patil, Dayanand;Chandam, Dattatraya;Mulik, Abhijeet;Jagdale, Suryabala;Patil, Prasad;Deshmukh, Madhukar. And the article was included in Research on Chemical Intermediates in 2015.Product Details of 73387-46-9 This article mentions the following:

An innovative designed novel crown ether functionalized imidazolium-based reusable acidic ionic liquid [crown ether MIm] [HSO4] has been efficiently implemented for the synthesis of pyrazole derivatives using various substituted enaminones, hydrazine hydrate and Ph hydrazine under solvent-free conditions. Structural novelty and task efficiency of the catalyst, high yields of desired products, greener approach attributing high atom economy (green chem. method) and solvent-free conditions render this protocol suitable to cope with the current demand in contemporary organic chem. The inventive idea of utilizing crown ether functionalized ionic liquid as a catalyst was for the first time demonstrated in this protocol. The synthesis of the target compounds was achieved using [6-[1,4,7,10,13-benzopentaoxacyclopentadecin-15-yl]hexyl]imidazolium sulfate as a catalyst. Starting materials included hydrazine, phenylhydrazine and enaminone derivatives [(amino)alkenone derivatives] such as 3-(dimethylamino)-1-phenyl-2-propen-2-one, 3-(dimethylamino)-1-(2-furanyl)-2-propen -1-one, 2-[(dimethylamino)methylene]-1,3-cyclohexanedione. The title compounds thus formed included pyrazole derivatives and analogs, such as 3-phenyl-1H-pyrazole, 3-(2-furanyl)-1H-pyrazole, 1,5,6,7-tetrahydro-4H-indazol-4-one (indazole derivatives). In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Product Details of 73387-46-9).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Product Details of 73387-46-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Aruri, Hariprasad et al. published their research in Journal of Organic Chemistry in 2017 | CAS: 73387-46-9

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application of 73387-46-9

Metal-free Cross-Dehydrogenative Coupling of HN-azoles with 浼?C(sp3)-H Amides via C-H Activation and Its Mechanistic and Application Studies was written by Aruri, Hariprasad;Singh, Umed;Kumar, Mukesh;Sharma, Sumit;Aithagani, Sravan Kumar;Gupta, Vivek K.;Mignani, Serge;Vishwakarma, Ram A.;Singh, Parvinder Pal. And the article was included in Journal of Organic Chemistry in 2017.Application of 73387-46-9 This article mentions the following:

A metal-free one step coupling reaction between various N-azole rings and diverse 浼?C(sp3)-H containing amides has been developed under oxidative reaction conditions. Com. available tetrabutylammonium iodide (TBAI) in the presence of tert-Bu hydroperoxide (TBHP), under neat reaction conditions, efficiently catalyzed the coupling. Various azole types, such as 1H-benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazoles, and 1H-benzimidazoles, and 浼?C(sp3)-H containing amides, such as N,N-dimethylacetamide, N,N-dimethylbenzamide, N-methylacetamide, N,N-diethylacetamide, N-methylpyrrolidine, and pyrrolidin-2-one, were successfully employed for the coupling. A series of designed and controlled experiments were also performed in order to study the involvement of the different intermediates. Based on the evidence, a plausible mechanism is also proposed. These novel, simple, rapid, attractive, and straightforward transformations open the way of the construction of novel highly functionalized N-azoles via direct covalent N-H bond transformations onto N-C bonds. This approach allows to the synthesis of complex mols. requiring number of steps using classical synthetic ways. In addition, the range of 浼?C(sp3)-H containing amide substrates is virtually unlimited highlighting the potential value of this simple system for the construction of complex heterocyclic mols., such as fused azole derivatives In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Application of 73387-46-9).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application of 73387-46-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Khachikyan, R. Dzh. et al. published their research in Russian Journal of General Chemistry in 2016 | CAS: 73387-46-9

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Category: pyrazoles-derivatives

Features of reactions of (E)-1-(β-aroylvinyl)pyridinium bromides with binucleophiles was written by Khachikyan, R. Dzh.;Ovakimyan, Z. G.;Panosyan, G. A.;Tamazyan, R. A.;Ayvazyan, A. G.. And the article was included in Russian Journal of General Chemistry in 2016.Category: pyrazoles-derivatives This article mentions the following:

Reactions of (E)-1-(β-aroylvinyl)pyridinium bromides with hydrazine led to the formation of pyrazole derivatives I•HCl (R = Me, Cl, Br) regardless of pH and a solvent nature. The salts reacted with thiourea via intermediate formation of 4-arylpyrimidine-2-thiol to gave (Z)-2-[(β-aroylvinyl)sulfanyl]-4 arylpyrimidines II (R = Me, Cl, Br). In the case of N,N’-diphenylthiourea the reaction provided 6-aryl-3-aroyl-1-phenylpyridinium bromides III•Br– (R = Me, Cl, Br). Pyridine hydrobromide liberated in the reaction course had a major influence on the process chemoselectivity. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Category: pyrazoles-derivatives).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Katane, Masumi et al. published their research in Journal of Medicinal Chemistry in 2013 | CAS: 73387-46-9

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Computed Properties of C9H7BrN2

Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro was written by Katane, Masumi;Osaka, Naoko;Matsuda, Satsuki;Maeda, Kazuhiro;Kawata, Tomonori;Saitoh, Yasuaki;Sekine, Masae;Furuchi, Takemitsu;Doi, Issei;Hirono, Shuichi;Homma, Hiroshi. And the article was included in Journal of Medicinal Chemistry in 2013.Computed Properties of C9H7BrN2 This article mentions the following:

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO. In the experiment, the researchers used many compounds, for example, 3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9Computed Properties of C9H7BrN2).

3-(4-Bromophenyl)-1H-pyrazole (cas: 73387-46-9) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Computed Properties of C9H7BrN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some scientific research about 3-(4-Bromophenyl)-1H-pyrazole

The synthetic route of 73387-46-9 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 73387-46-9

Production Example 138 3-(4-Bromophenyl)-1-trityl-1H-pyrazole 32.71 g of the title compound was obtained as pale brown crystals from 6.74 g 3-(4-bromophenyl)-1H-pyrazole (compound in Production Example 125) by the same method as in Production Example 15.1H-NMR (CDCl3) delta: 6.51(d, J=2.4Hz, 1H), 7.20(m, 6H), 7.29(m, 10H), 7.45(d, J=8.8Hz, 2H), 7.65(d, J=8.8Hz, 2H)

The synthetic route of 73387-46-9 has been constantly updated, and we look forward to future research findings.

Extracurricular laboratory: Synthetic route of 73387-46-9

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Adding a certain compound to certain chemical reactions, such as: 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73387-46-9, Recommanded Product: 3-(4-Bromophenyl)-1H-pyrazole

(2) 3-(4-bromophenyl)-1-methylpyrazole and 5-(4-bromophenyl)-1-methylpyrazole Sodium hydride (0.43 g, 17.9 mmol) was added slowly to a solution of 3-(4-bromophenyl)-1H-pyrazole (1.0 g, 4.48 mmol) in 50 ml of THF under N2. The mixture was stirred for 1 h, then iodomethane (1.27 g, 8.97 mmol) was added to the suspension. The mixture was stirred at 23 for 2 h. Water (20 mL) was added and extracted with EtAc (50 mL¡Á3). The combined organic phase was washed with brine, dried, concentrated and purified by column chromatography to give 1.0 g of colorless liquid (mixture) (yield: 90%). LC-MS (Method B): m/z 237 (M+H) RT=1.62 min/2.5 min

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Analyzing the synthesis route of 73387-46-9

According to the analysis of related databases, 73387-46-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H7BrN2

To a heated (80 0C) solution of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol) and trifluoroacetic acid (0.02 mL, 0.23 mmol) in toluene (5 mL) was added 3,4-dihydro- 2H-pyran (0.43 mL, 4.7 mol) over 1 hour. The reaction mixture was stirred for an additional hour and was then concentrated and dried to provide 3-(4-bromophenyl)-l-(tetrahydro-2H- pyran-2-yl)-lH-pyrazole (1.3 g, 94% yield). MS (EI) for Ci4H15BrN2O: 308 (MH+).

According to the analysis of related databases, 73387-46-9, the application of this compound in the production field has become more and more popular.

Simple exploration of 73387-46-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Bromophenyl)-1H-pyrazole, and friends who are interested can also refer to it.

Reference of 73387-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73387-46-9 name is 3-(4-Bromophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0001228] A mixture of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol), cyclopropylboronic acid (0.8 g, 9 mmol), Cu(OAc)2 (1.6 g, 9 mmol), Na2C03 (0.9 g, 9 mmol), bipyridine (1.4 g, 9 mmol), and 4 A molecular sieve powder (5 g) in 1,2- dichloroethane (20 mL) was stirred at 30 C for 72 h. After filtration, the mixture was diluted with dichloromethane (50 mL), washed with water (30 mL x 2) and brine (50 mL), dried over anhydrous sodium sulfate, and concentrated to give a crude compound. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 10% v/v) to afford Compound 349A.

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New learning discoveries about 73387-46-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(4-Bromophenyl)-1H-pyrazole, its application will become more common.

Application of 73387-46-9,Some common heterocyclic compound, 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole, molecular formula is C9H7BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate A4 6-methoxy-2-(4-( 1 -methyl- 1 H-pyrazol-3 -yl)phenyl)-3.4-dihydroisoquinolin- 1 (2H)-one and 6-methoxy-2-(4-(l -methyl- lH-pyrazol-5-yl)phenyl)-3.4-dihydroisoquinolin-l(2H)-one Step 1 : 3-(4-bromophenyl)-lH-pyrazole (0.377 g, 1.690 mmol) was dissolved in THF (8.45 ml). 60% Sodium hydride in oil (0.101 g, 2.54 mmol) was added and the reaction was stirred at rt for 15 min. Methyl iodide (0.116 ml, 1.859 mmol) was added and the reaction was stirred overnight at room temperature. The reaction was quenched with water and extracted three times with dichloromethane. The organic layers were combined, passed through a phase separator and concentrated. The crude material was purified via silica gel chromatography using 0-50% ethyl acetate in heptanes to afford a 2: 1 mixture of products (370 mg, 1.561 mmol, 92 % yield) as a yellow solid. NMR (400 MHz, CHLOROFORM-^ delta ppm 3.86 – 3.95 (m, 3 H), 3.97 (s, 6 H), 6.34 (d, J=1.52 Hz, 1 H), 6.54 (d, J=2.02 Hz, 2 H), 7.30 – 7.33 (m, 2 H), 7.40 (d, J=2.53 Hz, 2 H), 7.49 – 7.56 (m, 5 H), 7.59 – 7.64 (m, 2 H), 7.66 – 7.72 (m, 4 H). LC MS (m/z, MH+): 238.9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(4-Bromophenyl)-1H-pyrazole, its application will become more common.