Category: 215610-30-3

Sirbu, Doina; Diharce, Julien; Martinic, Ivana; Chopin, Nicolas; Eliseeva, Svetlana V.; Guillaumet, Gerald; Petoud, Stephane; Bonnet, Pascal; Suzenet, Franck published an article in 2019, the title of the article was An original class of small sized molecules as versatile fluorescent probes for cellular imaging.Category: pyrazoles-derivatives And the article contains the following content:

An unusual class, compact in size, of fluorescent probes based on pyridazino-1,3a,6a-triazapentalene scaffolds exhibits promising fluorescent properties (quantum yield values up to 73%, large Stokes shifts, emission wavelengths located in the green-yellow range, excellent solubility) with good photostability suitable for optical imaging applications. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Category: pyrazoles-derivatives

The Article related to fluorescent probe cell imaging, Biochemical Methods: Spectral and Related Methods and other aspects.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On April 11, 2013, Cox, Christopher D.; Beshore, Douglas C.; Kim, June J.; Kuduk, Scott D.; McVean, Carol; Reger, Thomas; Sheen, Justin published a patent.Name: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of 1,3-substituted azetidine PDE10 inhibitors for treatment of CNS disorders. And the patent contained the following:

The present invention is directed to substituted azetidine compounds of general formula I (wherein X1, X2 and X3 independently are CH or N; R is H and C1-6alkyl; R2 is H, (un)substituted O-C1-6alkyl, (un)substituted C1-3haloalkyl, etc.; R3 is NRC(O)R6, C(O)OR6, C(O)NR6R6, and (CH2)nC5-10heterocycle, said heterocycle is optionally substituted; R5 is (CH2)nC6-10 aryl, (CH2)nC5-10 heterocycle, (CH2)nC3-10cycloalkyl, the rings being optionally substituted; R6 is H, (un)substituted C1-6-alkyl, OR, etc.; n = 0-4) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurol. and psychiatric disorders, such as schizophrenia, psychosis or Huntington’s disease, and those associated with striatal hypofunction or basal ganglia dysfunction. Synthetic procedures for preparing I are exemplified. Example compound II was prepared by reacting intermediates 2-(azetidin-3-yl)-1-methyl-1H-benzimidazole and 4-chloro-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine. In a PDE10 inhibition assay, II had a Ki of 2.1 nM. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Name: 5-Methoxy-1H-pyrazole

The Article related to preparation azetidine compound pde10 inhibitor treatment cns disorder, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Name: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On January 26, 2017, Suzenet, Franck; Sirbu, Doina; Guillaumet, Gerald; Bonnet, Pascal published a patent.Recommanded Product: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of new polyazo heterocyclic compounds and their uses as fluorescent chromophores. And the patent contained the following:

The invention relates to the preparation and use as chromophoric fluorescent of compounds of formula I wherein A1 is N or C(Y1); A2 is N or C(Y2); A3 is N or C(Y3); A4 is N or C(Y4); at least one of A1, A2, A3 and A4 representing N; X1 is N or C(Y5); X2 is N or C(Y6); X3 is N or C(Y7); and Y1, Y2, Y3, Y4, Y5, Y6 and Y7 are in particular selected independently of one another from H, electron-donating groups and electron-withdrawing groups. Example compounds, such as II were prepared by multistep procedures (shown) and evaluated for their photophys. properties (data shown). Compounds I are useful as fluorescent chromophores for detection of mols. of biol. origin. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Recommanded Product: 5-Methoxy-1H-pyrazole

The Article related to polyazo heterocycle preparation fluorescent chromophore biol mol detection probe, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Recommanded Product: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On January 27, 2017, Suzenet, Franck; Sirbu, Doina; Guillaumet, Gerald; Bonnet, Pascal published a patent.Recommanded Product: 5-Methoxy-1H-pyrazole The title of the patent was Preparation of new polyazo heterocyclic compounds and their uses as fluorescent chromophores. And the patent contained the following:

The invention relates to the preparation and use as chromophoric fluorescent of compounds of formula I wherein A1 is N or C(Y1); A2 is N or C(Y2); A3 is N or C(Y3); A4 is N or C(Y4); at least one of A1, A2, A3 and A4 representing N; X1 is N or C(Y5); X2 is N or C(Y6); X3 is N or C(Y7); and Y1, Y2, Y3, Y4, Y5, Y6 and Y7 are in particular selected independently of one another from H, electron-donating groups and electron-withdrawing groups. Example compounds, such as II were prepared by multistep procedures (shown) and evaluated for their photophys. properties (data shown). Compounds I are useful as fluorescent chromophores for detection of mols. of biol. origin. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Recommanded Product: 5-Methoxy-1H-pyrazole

The Article related to polyazo heterocycle preparation fluorescent chromophore biol mol detection probe, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Recommanded Product: 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Doepp, H.; Doepp, D. published an article in 2004, the title of the article was Product subclass 1: 1,2,3-triazines and phosphorus analogues.Related Products of 215610-30-3 And the article contains the following content:

A review. Methods for preparing triazines and their phosphorus analogs are reviewed including cyclization, ring transformation, aromatization, and substituent modification. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Related Products of 215610-30-3

The Article related to review triazine phosphorus analog preparation cyclization ring transformation aromatization, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Related Products of 215610-30-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On January 6, 2016, Lian, Lei; Zheng, Yurong; He, Bin; Peng, Xuegang; Jin, Tao; Cui, Qi published a patent.Safety of 5-Methoxy-1H-pyrazole The title of the patent was Pyrazole ketone compound or salt thereof, preparation method, herbicidal composition and application. And the patent contained the following:

The inventive pyrazole ketone compound has structure shown as general formula I, wherein R1R2N represents (un)substituted 3-8 membered nitrogen-containing heterocyclic group containing 1-3 hetero atoms, or R1 and R2 are independently H, alkyl, heteroalkyl, etc.; R3 is H, alkyl, alkenyl, alkynyl, cycloalkyl or alkyl substituted cycloalkyl; R4 is Me, Et, Pr, iso-Pr, or cyclopropyl; X is H, S(O)nR6, R7, or (substituted) 3-8 membered heterocyclic group containing 1-4 hetero atoms, n is 1, 2 or 3; R6 is (un)substituted alkyl or aryl, R7 is (un)substituted alkyl, aryl, alkanoyl or aroyl. Compounds of the invention were prepared and evluated for their herbicidal activity on various crops (data given). The pyrazole ketone compound has good herbicidal effect, convenient application, low cost, and high com. value. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Safety of 5-Methoxy-1H-pyrazole

The Article related to pyrazole ketone preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Safety of 5-Methoxy-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On November 17, 2011, Mulvihill, Mark J.; Steinig, Arno G.; Crew, Andrew Philip; Jin, Meizhong; Kleinberg, Andrew; Li, An-Hu; Wang, Jing published a patent.Category: pyrazoles-derivatives The title of the patent was Preparation of fused bicyclic heterocycles as kinase inhibitors. And the patent contained the following:

Title compounds I [X = H, (C1-3)alkyl, O(C1-3)alkyl, either is optionally substituted with halo or CN; W-V = C-N or N-C; Y1, Y2 = N or CH as long as not more than one of Y1 and Y2 is N; Y3 = NH, CH; Y4 = N, CH; Y5 = N, C as long as not more than one of Y4 and Y5 is N; R3 , R4, R5, R6, R7 = H, alkyl, cyclic compound, O-alkyl, O-cyclic compound, S, SO2, SO, NH2, CONH2, CO2H, acyl, ureido, S-cyclic compound; G1 = H, alkyl, cyclic compound; R17, R18 = H, alkyl, O-alkyl, CONH2, cyclic compound, CO2H, NH2] were prepared and tested in different kinase inhibitory assays. For example, reacting (4-bromo-1-methyl-1H-pyrazol-3-yl)methanol with borane II gave pyrrolo[2,3-b]pyridine III. The compounds are also useful for treating cancers in part by inhibiting different kinases such as MET, RON, or ALK. This abstract is not limiting of the invention. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Category: pyrazoles-derivatives

The Article related to bicyclic heterocycle fused preparation anticancer kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On April 3, 2014, Wilson, Kevin J.; Witter, David J.; Daniels, Matthew H.; Angeles, Angie R.; Siliphaivanh, Phieng; Sloman, David; O’Boyle, Brendan; Falcone, Danielle; White, Catherine; Ferguson, Ron; Zhou, Wei; Lipford, Kathryn; Mansoor, Umar Faruk; Fevrier, Salem; Huang, Xianhai; Kurukulasuriya, Ravi; Richard, Judson E.; Tang, Shuyi; Boyce, Christopher; Kozlowski, Joseph; Bakshi, Raman Kumar; Karunakaran, Ganesh Babu published a patent.Electric Literature of 215610-30-3 The title of the patent was Preparation of pyrazolopyridinyl ureas as ERK inhibitors. And the patent contained the following:

The title compounds I [R1 = OR4, S(O)tR5; t = 0-2; R2 = H, alkyl; alkyl-O-alkyl, alkylaryl, etc.; R4 = alkyl-O-alkyl, alkylaryl, etc.; R5 = alkyl, alkyl-O-alkyl; R10, R11 = H, halo, alkyl, etc.] which are ERK inhibitors useful in treating cancer, were prepared E.g., a multi-step synthesis of (1R)-II, starting from Me 4,6-dichloropyridine-3-carboxylate and hydrazine, was described. Exemplified compounds I were tested in human ERK2 activity assay (data given). Pharmaceutical compositions comprising compound I, alone or in combination with an effective amount of at least one chemotherapeutic agent, were disclosed. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Electric Literature of 215610-30-3

The Article related to pyrazolopyridinyl urea preparation erk inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Electric Literature of 215610-30-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On May 11, 2017, Lian, Lei; Zheng, Yurong; He, Bin; Peng, Xuegang; Jin, Tao; Cui, Qi published a patent.Computed Properties of 215610-30-3 The title of the patent was Pyrazole ketone compound or salt thereof, preparation method, herbicidal composition and application. And the patent contained the following:

The inventive pyrazole ketone compound has structure shown as general formula I, wherein R1R2N represents (un)substituted 3-8 membered nitrogen-containing heterocyclic group containing 1-3 hetero atoms, or R1 and R2 are independently H, alkyl, heteroalkyl, etc.; R3 is H, alkyl, alkenyl, alkynyl, cycloalkyl or alkyl substituted cycloalkyl; R4 is Me, Et, Pr, iso-Pr, or cyclopropyl; X is H, S(O)nR6, R7, or (substituted) 3-8 membered heterocyclic group containing 1-4 hetero atoms, n is 1, 2 or 3; R6 is (un)substituted alkyl or aryl, R7 is (un)substituted alkyl, aryl, alkanoyl or aroyl. Compounds of the invention were prepared and evaluated for their herbicidal activity on various crops (data given). The pyrazole ketone compound has good herbicidal effect, convenient application, low cost, and high com. value. The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Computed Properties of 215610-30-3

The Article related to pyrazole ketone preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 215610-30-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On February 11, 2010, Janin, Yves; Guillou, Sandrine published a patent.Computed Properties of 215610-30-3 The title of the patent was Preparation of alkoxypyrazoles. And the patent contained the following:

The invention relates to a process for the preparation of alkoxypyrazoles I and their isomers, wherein R1 is (un)substituted alkyl, alkenyl, or alkynyl, etc.; R2 is H, halo, substituted alkyl, alkenyl, or alkynyl; R3 is H, halo, (un)substituted alkyl, or aryl, etc.; R4 is H, (un)substituted alkyl, aryl, or heteroaryl, etc. For instance, heterocyclization of diethylethoxymethylenemalonate with NH2NH2 gave Et 3-ethoxy-1H-pyrazole-4-carboxylate (41%) and 2,3-dihydro-3-oxo-1H-pyrazole-4-carboxylic acid Et ester (37%). The experimental process involved the reaction of 5-Methoxy-1H-pyrazole(cas: 215610-30-3).Computed Properties of 215610-30-3

The Article related to alkoxypyrazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 215610-30-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics