Category: 83725-05-7

Electric Literature of 83725-05-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 83725-05-7 as follows.

A mixture of N-(5-methyl-1H-pyrazol-3-yl)acetamide (1.448 g, 10.4 mmol),1 3,4-dihydro-2H-pyran (2.39 mL, 26.0 mmol) and trifluoroacetic acid (15 muL, 0.208 mmol) in anhydrous MeCN (15 mL) was refluxed for 2 h. Solvent was evaporated and the residue was resuspended in CH2Cl2 (50 mL) and washed with H2O and brine. After drying with Na2SO4, solvent evaporation and silica gel column chromatography (PE-EtOAc, 6:4) N-(5-Methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)acetamide (1.87 g, quantitative) was obtained. 1Lu, Y.; Kraatz, H.-B. Inorg. Chim. Acta 2004, 357, 159-1661H NMR (400 MHz, CDCl3): =7.61 (bs, 1H), 6.50 (s, 1H), 5.15 (dd, J=10.0 Hz, J=2.4 Hz, 1H), 4.05 (d, J=11.4 Hz, 1H), 3.63 (dt, J=11.8 Hz, J=2.5 Hz, 1H), 2.31 (s, 3H), 2.30 (m, 1H), 2.09 (s, 3H), 2.06 (m, 1H), 1.86 (d, J=11.0 Hz, 1H), 1.63-1.67 (m, 3H).MS (ESI): m/z=224.37 [MH+].

According to the analysis of related databases, 83725-05-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AC IMMUNE SA; US2010/144793; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 83725-05-7, name is N-(5-Methyl-1H-pyrazol-3-yl)acetamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83725-05-7, HPLC of Formula: C6H9N3O

4.1.2 N-(5-methyl-4-nitro-1H-pyrazol-3-yl)acetamide (3) Compound 2 (4.5g, 32?mmol) was dissolved in 50?mL concentrated H2SO4, and the solution was cooled to -5?C. Concentrated HNO3 (2.3?mL, 32?mmol) was added dropwise and the mixture was maintained at -5?C for 3?h. The reaction mixture was added to 150?mL ice water slowly, and then white solid appeared with stirring. The solid washed by water and dried to give pure 3 (4.65?g, 25?mmol, 72% yield). Mp: 240-241?C; 1H NMR (400?MHz, DMSO-d6) delta 10.24 (s, 1H), 2.45 (s, 3H), 2.13 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(5-Methyl-1H-pyrazol-3-yl)acetamide, other downstream synthetic routes, hurry up and to see.