Category: 56426-35-8

Extracurricular laboratory: Synthetic route of 56426-35-8

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56426-35-8, name is Methyl 5-phenyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 5-phenyl-1H-pyrazole-3-carboxylate

Intermediate 96 (320mg, 1.58mmol) was dissolved in THF/water (15mL, 1 :1), lithium hydroxide monohydrate (146mg, 3.48mmol) was added and the reaction mixture was stirred for 2h. The THF was removed in vacuo and the aqueous solution was acidified to pH 1 with 1M aq HCl. The precipitate was collected by filtration to give the title compound (232mg, 78%) as a yellow solid. LCMS: ES+ 189.0 [MH]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Sources of common compounds: 56426-35-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-phenyl-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

Related Products of 56426-35-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56426-35-8 name is Methyl 5-phenyl-1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 96 (320mg, 1.S8mmol) was dissolved in THF/water (l5mL, 1:1), lithiumhydroxide monohydrate (146mg, 3.48mmol) was added and the reaction mixture wasstirred for 2h. The THF was removed in vacuo and the aqueous solution was acidified to pH 1 with 1M aq HC1. The precipitate was collected by filtration to give the title0 . + +compound (232mg, 78/o) as a yellow solid. LCMS: ES 189.0 [IVIH]

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-phenyl-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.