Category: 943541-20-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H7ClN4

1.4 A suspension of 3.89 g (20.0 mmol) of 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine and 4.58 g (20.0 mmol) of (3-bromophenyl)acetohydrazide in 40 ml of 1-butanol is heated at 130 C. for 18 hours. The reaction mixture is cooled and partitioned between ethyl acetate and saturated sodium hydrogencarbonate solution. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica-gel column with dichloromethane /tert-butyl methyl ether /methanol as eluent: 3-(3-bromobenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo-[4,3-b]pyridazine as beige crystals; ESI 369, 371.

The synthetic route of 943541-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2011/92498; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 943541-20-6

Quinazolin-6-yl-acetic acid hydrazide (0.032 g, 0.158 mmol) and 3-chloro-6-(l- methyl-lH-pyrazol-4-yl)-pyridazine (0.031 g, 0.158 mmol) were heated to 165C in 5 butanol (2 mL) for five hours. The reaction was cooled to room temperature, evaporated in vacuo and purified via silica gel column chromatography eluting with 5% methanol in dichloromethane to give 0.0031g (7%) of 6-[6-( 1 -methyl- IH- pyrazol^-yO-tl^^triazolo^.S-blpyridazin-S-ylmethyll-quinazoline. 1H NMR (400 MHz, CD3OD) 5 8.45 (s, IH), 8.29 (s, IH), 8.06 (d, 2H, J=9.6Hz), 7.60 (d, 2H, J=9.6Hz), 7.55 (m, IH), 7.17 (d, IH, J==8.0Hz), 6.08 (s, IH), 4.58 (m, 2H), 3.89 (s, 3H). Mass spectrum (LCMS, ESI pos.): Calcd for Ci8H)4N8; found: 343.3 (M+H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 943541-20-6.

Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/75567; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 943541-20-6

1.4 A suspension of 3.89 g (20.0 mmol) of 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine and 4.58 g (20.0 mmol) of (3-bromophenyl)acetohydrazide in 40 ml of 1-butanol is heated at 130 C. for 18 hours. The reaction mixture is cooled and partitioned between ethyl acetate and saturated sodium hydrogencarbonate solution. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica-gel column with dichloromethane /tert-butyl methyl ether /methanol as eluent: 3-(3-bromobenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo-[4,3-b]pyridazine as beige crystals; ESI 369, 371.

The synthetic route of 943541-20-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2011/92498; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, A new synthetic method of this compound is introduced below., SDS of cas: 943541-20-6

A mixture of 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (494 mg, 2.5 mmol) in AcOH (20 mL) was stirred at 120 C for 4 h. The reaction mixture was concentrated under reduced pressure, and water was added to the concentrates. The generated solids was filtered and dried to afford 6-(1-methyl-1H-pyrazol-4-yl)pyridazin-3(2H)-one (431 mg, 98 %). 6-(1-Methyl-1H-pyrazol-4-yl)pyridazin-3(2H)-one (2a) 1HNMR (300 MHz, CDCl3) delta 8.70 (d, J = 11.3 Hz, 1H), 7.96(s, 1H), 6.94 (s, 1H), 6.62 (d, J = 11.3 Hz, 1H), 3.95 (s, 3H).

The synthetic route of 943541-20-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

STEP 2: 6-fluoro-1-M-f6-M-methyl-1 H-Dyrazol-4-yl)Dyridazin-3-yl)DiDeridin-4- vDindoline To a mixture of 6-fluoro-1-(piperidin-4-yl)indoline (256 mg, 1 mmol), 3- chloro-6-(1-methyl-1 H-pyrazol-4-yl)pyridazine prepared as in STEP 1 above (194 mg, 1.0 mmol) in DMSO (3 mL) was added DIPEA (0.52 mL, 3 mmol). The resulting mixture was sealed and heated at 180C for 1 .5 h under microwave irradiation. The resulting mixture was poured into H20 (30 mL) and the aqueous layer was extracted with 30% CH2Cl2/Et20 (30 mL x 5). The combined organic layer was dried (Na2S04) and filtered. The solvent was removed and the resulting residue was purified by column using 90-100% EtOAc/hexane as the eluent to yield the title compound, 6-fluoro-1 -(1-(6-(1- methyl-1 H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)indoline.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 943541-20-6.

Reference of 943541-20-6,Some common heterocyclic compound, 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, molecular formula is C8H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 13: A route to prepare compound (I)6-{difluoror6-(1-methvl-1 H-pvrazol-4-vl)? ,2,41triazolor4,3-lpvridazin-3-vnmethvl>quinolineStep 1 : tert-butyl 2-f6-(1-methyl-1 H-pyrazol-4-yl)pyridazin-3-vnhvdrazinecarboxylatetert-butyl carbazate, 8,98g (67,3 mmol) and 3-chloro-6-(1-methyl-1 /-/-pyrazol-4- yl)pyridazine (11 ,9 g, 61 ,1 mmol) were mixed in 1-butanol (245 ml_). This mixture was heated till 900C and stirred at that temperature for 16h. The reaction mixture was cooled and water (250 ml_) and ethylacetate (250 mL) were added. The biphasic mixture was neutralised with sodium hydrogencarbonate till the pH is 7. Then the organic layer was separated and the water layer was extracted with ethylacetate (250 mL). The combined organic layers were washed once with water (250 mL) and evaporated. The residue was stirred in isopropylether, filtered off and dried under vacuum. Yield: 5,9 g (20,3 mmol; 33%) of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, its application will become more common.