Category: 16078-71-0

Adding a certain compound to certain chemical reactions, such as: 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16078-71-0, Recommanded Product: Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate

A mixture of 1.50 g (6 mmol) of ethyl 5-amine-1-phenyl-1Hpyrazole-4-carboxylate (13) and 20 mL of 85% phosphoric acidwas maintained under reflux and stirring for 6 h at 170 C. Aftercompletion of the reaction, 50 mL of crushed ice was added, andthen the mixture was basified to pH 7 with NaOH (6 M aq). Themixture was extracted with dichloromethane (3 30 mL). Thecombined organic solution was washed with water (3 50 mL),dried (anhydrous sodium sulfate), filtered, and concentrated undervacuum to afford 14 as a brown oil.Yield: 86%. IR (KBr. cm1): 3418-3182; 1618; 1597; 1550;760-694. 1H NMR (400 MHz, CDCl3, TMS, d in ppm): 3.84 (s, 2H,NH2); 5.61 (d, 1H, J = 2.0 Hz, H4); 7.42 (d, 1H, J = 1.8 Hz, H3);7.57-7.32 (m, 5H, H20, H30, H40, H50, H60). 13C NMR (100 MHz,CDCl3, TMS, d in ppm): 90.6; 123.9; 127.4; 129.4; 138.6; 140.3;144.7. EI [M1] 157.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Silva, Thais B.; Bernardino, Alice M.R.; Ferreira, Maria de Lourdes G.; Rogerio, Kamilla R.; Carvalho, Leonardo J.M.; Boechat, Nubia; Pinheiro, Luiz C.S.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4492 – 4498;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 16078-71-0, These common heterocyclic compound, 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 5-amino-1-phenylpyrazole-4-carboxylate (2.31 g) was added to 20 mL of formamide and heated to 180 C. for 4 hours.Cool to room temperature, add 30ml of water, filter and filter cake washed with ethanol (2 x 10mL).Obtained 1-phenyl-pyrazole [3,4-d]pyrimidine-4-one, 1.93 g, 91% yield, HPLC: 98.08%.

Statistics shows that Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 16078-71-0.

Reference:
Patent; Central South University of Forestry and Technology; Ma Qiang; Wang Wenlei; Hu Yunchu; Xie Lianwu; Wen Ruizhi; (8 pag.)CN107955008; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C12H13N3O2

B. 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester To a solution of 20.0 g of 5-amino-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester and 10 ml of bromine in 200 ml of chloroform was added 15.8 g of isoamyl nitrite dropwise. The reaction mixture was allowed to stir at room temperature for about 24 hours and the volatiles were removed under reduced pressure. The residue was recrystallized from ethanol/water to provide 10.0 g of 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester. Yield 38%. mp=86-89 C.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16078-71-0.

Reference:
Patent; Eli Lilly and Company; US4620865; (1986); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 16078-71-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

[00139] A solution of 1 ,2-bis-(4-chloro-phenyl)-ethanone (lOOmg, 0.38 mmol) in dichloroethane (1 mL) is stirred at room temperature while TiCl4 (143 mg, 0.75 mmol) is added in dropwise. After the addition, the mixture is stirred at room temperature for 5 min and a solution of 5-amino-l-phenyl-lH-pyrazole-4-carboxilic acid ethyl ester (97 mg, 0.42 mmol) in dichloroethane (1 mL) is added dropwise. After the addition, the EPO mixture is heated to 125 0C for 5 h. After cooling down the mixture, it is poured into a mixture of ice cold saturated aqueous NaHCO3 solution (15 mL) and EtOAc (15 mL). The resulted mixture is filtered through celite to remove the precipitate and washed with EtOAc (2×5 mL). The filtrate is extracted by EtOAc (3*5 mL). The organic layers are combined and washed with brine and dried (MgSO4). After filtering off the drying agent, the filtrate is concentrated and purified by preparative LC/MS to provide the titled compound 5,6-bis-(4-chloro-phenyl)-l-phenyl-lH-pyrazolo[3,4-b]pyridin-4-ol as light yellow solid.(55 mg, 31%). 1H NMR (MeOD) delta(ppm) 8.37(s, IH), 8.23 (d, 2H), 7.53 (t, 2H), 7.34(t, IH), 7.31 (d, 2H), 7.29 (d, 2H), 7.23 (d, 2H), 7.15 (d, 2H); HPLC-MS calculated for C24H15Ci2N3O (M+l+): 432.1, found: 432.2.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; IRM LLC; WO2006/47516; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 16078-71-0, These common heterocyclic compound, 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 5-amino-1-phenylpyrazole-4-carboxylate (2.31 g) was added to 20 mL of formamide and heated to 180 C. for 4 hours.Cool to room temperature, add 30ml of water, filter and filter cake washed with ethanol (2 x 10mL).Obtained 1-phenyl-pyrazole [3,4-d]pyrimidine-4-one, 1.93 g, 91% yield, HPLC: 98.08%.

Statistics shows that Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 16078-71-0.

Reference:
Patent; Central South University of Forestry and Technology; Ma Qiang; Wang Wenlei; Hu Yunchu; Xie Lianwu; Wen Ruizhi; (8 pag.)CN107955008; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16078-71-0, Recommanded Product: 16078-71-0

A mixture of 1.50 g (6 mmol) of ethyl 5-amine-1-phenyl-1Hpyrazole-4-carboxylate (13) and 20 mL of 85% phosphoric acidwas maintained under reflux and stirring for 6 h at 170 C. Aftercompletion of the reaction, 50 mL of crushed ice was added, andthen the mixture was basified to pH 7 with NaOH (6 M aq). Themixture was extracted with dichloromethane (3 30 mL). Thecombined organic solution was washed with water (3 50 mL),dried (anhydrous sodium sulfate), filtered, and concentrated undervacuum to afford 14 as a brown oil.Yield: 86%. IR (KBr. cm1): 3418-3182; 1618; 1597; 1550;760-694. 1H NMR (400 MHz, CDCl3, TMS, d in ppm): 3.84 (s, 2H,NH2); 5.61 (d, 1H, J = 2.0 Hz, H4); 7.42 (d, 1H, J = 1.8 Hz, H3);7.57-7.32 (m, 5H, H20, H30, H40, H50, H60). 13C NMR (100 MHz,CDCl3, TMS, d in ppm): 90.6; 123.9; 127.4; 129.4; 138.6; 140.3;144.7. EI [M1] 157.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Silva, Thais B.; Bernardino, Alice M.R.; Ferreira, Maria de Lourdes G.; Rogerio, Kamilla R.; Carvalho, Leonardo J.M.; Boechat, Nubia; Pinheiro, Luiz C.S.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4492 – 4498;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 16078-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2 (0.01 mol), and ethyl-5-amino-1-phenyl-1Hpyrazole-4-carboxylate in 1,4-dioxane 10 ml containingthree drops of triethylamine was heated under reflux for 3 h.The reaction mixture was poured into crushed ice water, andacidified with dil. HCl. The solid obtained was recrystallizedfrom dioxane to give 17. White needles; yield 69%;mp. 130-131oC; IR (KBr) numax 3344, 3217 (2NH), 2927(CH-aliph.), 1658 (C=O), 1624 (C=N), 1384, 1157 cm-1(SO2); 1H NMR (DMSO-d6, 300 MHz,): delta = 1.23 (t, 3H,CH3), 4.47 (q, 2H, CH2), 5.67 (s, 2H, pyrazole-H), 6.47 (s,1H, pyrazole-H), 7.4-7.64 (m, 15H, Ar- H+ NH), 10.37,11.71 ppm (2s, 2H, 2NH, exchangeable with D2O); EIMSm/z 558 (M-29 (C2H5)), 73 (100); anal. calcd. ForC28H25N7O4 S2: C, 57.23; H, 4.29; N, 16.68. Found: C,57.40; H, 4.50; N, 16.90.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 16078-71-0, The chemical industry reduces the impact on the environment during synthesis 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

In the with the condensation tube, thermometer of 250 ml three-neck bottle in, adding […] ethyl acetate (62.1 mmol), phenyl hydrazine (93.2 mmol), ethanol (50 ml), heated to 80 C, reaction 24 h, TLC detection after the reaction, to the room temperature, the solvent is distilled under reduced pressure, the remaining solid without purification directly dissolved in absolute ethanol (200 ml), 80% hydrazine hydrate solution (100 mmol) is slowly added in the reaction solution, heating to reflux 2 hours, TLC detection reaction is over, the system to the room temperature, filtered, washing the solid with ethanol, dry and obtain the product, a white solid, yield 70.5%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 16078-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation of compound 1-2 [80] The compound 1-1 (30 g, 0.12 mol) was dissolved in hydrazine hydrate (70 mL) and the mixture was stirred for 2hours at 100C. Upon completion of the reaction, the temperature was slowly raised to room temperature and then a solid was produced. Washing the solid with diethyl ether and filtering under reduced pressure gave a compound 1-2(26g,92%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.