Category: 304903-10-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Quality Control of 1-Ethyl-1H-pyrazole-4-carbaldehyde

in room temperature, Mix 1-ethyl-1H-pyrazole-4-carbaldehyde (12.4 g, 0.1 mol), sodium bromate (30.2 g, 0.2 mol) and 200 g of acetic acid, and add 50 g of ammonia containing 25% molecular weight of ammonia. And 600 ml of water, heated to 90 C, the reaction is exothermic, maintain the reaction temperature of 100 C, reflux reaction for 1 hour until 1-ethyl-1H-pyrazole-4-carbaldehyde complete reaction, the reaction solution is cooled to room temperature, poured into The mixture was diluted with ice water, neutralized until the reaction solution was neutral, extracted with ethyl acetate, dried, concentrated, and then distilled under reduced pressure and recrystallized to give 11.1 g of product, yield 92%, purity over 99%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; (14 pag.)CN108707113; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 304903-10-4, These common heterocyclic compound, 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1-ethylpyrazole-4-carbaldehyde [0.322 g (2.6 mmol)], malonic acid [0.530 g (5.2 mmol)], pyridine (5 mL) and piperidine (0.050 mL) was stirred at 80 C. for 1 h followed by stirring for 3 h at 115 C. The reaction was then poured into water (100 mL) and acidified with conc. HCl. The resulting white ppt., product, was filtered and vacuum dried. Yield=436 mg (99%) MS (m/z): 169 [M+H]

Statistics shows that 1-Ethyl-1H-pyrazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 304903-10-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H8N2O

General procedure: Corresponding aryl-carbaldehyde (1.0 eq.) and l-(triphenyl-phosphanylidene)propan-2-one (1.2 eq.) were dissolved in DCM. The mixture was stirred at r.t for 1-168 hours. The solvent was evaporated. The residue was purified by flash chromatography (hexane:EEO) to give the appropriate (¡ê)-4-(aryl)but-3-en-2-one.

According to the analysis of related databases, 304903-10-4, the application of this compound in the production field has become more and more popular.

Reference of 304903-10-4, These common heterocyclic compound, 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 24: {3′-[4-(l-Ethyl-lH-pyrazol-4-ylmethyl)-piperazin-l-yl]-3,4,5,6-tetrahydro- 2H-[1, 2′]bipyridinyl-4-yl} -methanol hydrochlorideHCl To a solution of (3′-piperazin-l-yl-3,4,5,6-tetrahydro-2H-[l,2′]bipyridinyl-4- yl)-methanol (0.145 g, 0.524 mmol, 1 eq) and 1 -ethyl- lH-pyrazole-4-carbaldehyde (97.69 mg, 0.787 mmol, 1.5 eq) in 1 ,2-dichloroethane (10 mL) add sodium triacetoxyborohydride (166.79 mg, 0.787 mmol, 1.5 eq) in one portion as a solid. Stir the mixture at room temperature under nitrogen for 20 hr. Add 2 M aqueous sodium hydroxide solution (20 ml) and DCM (20 ml). Separate using a phase separator and extract the aqueous layer with DCM (10 ml). Concentrate the combined organic extracts and purify by high pH reverse phase HPLC. Dissolve this material (120 mg, 0.31 mmol) in the minimum quantity of 50% aqueous acetonitrile. Add 2 M aqueous hydrogen chloride (155 muL, 0.31 mmol) and lyophilize to give the title compound (127 mg, 58%). MS (m/z): 385.2 (M+l).

The synthetic route of 304903-10-4 has been constantly updated, and we look forward to future research findings.