Category: 95162-14-4

Related Products of 95162-14-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95162-14-4 as follows.

Intermediate 12: Methyl [N- (TERT-BUTOXVCARBONYL)-4- (1-TRITYL-1H-PVRAZOL-4-VL)-L-PHENVLALANINATE] To a mixture of [BROMOPYRAZOLE] (11) (1. 0g, 2. [56MOL),] boronic acid (1) (0.7g, 2. [14MMOL),] and potassium carbonate (1.5g, 10. [7MMOL)] in degassed DME [(10ML)] was added [PDCI2 [DPPF]] (0.088g, [0.] [1MMOL).] The reaction mixture was then heated to [70C] under nitrogen for 24 hours. Solvent was then removed in vacuo, and the residue was partitioned between ethyl acetate and water. The organic portion was dried over sodium sulphate and solvent evaporated in vacuo to give the crude product. Purification via silica gel chromatography (ethyl acetate/petroleum ether 40-60 1: 4) gave the title compound (0.74g) LCMS RT 4.11 min, [[CPH3] + 243]

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2003/104200; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 95162-14-4, name is 4-Bromo-1-tritylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 95162-14-4, Computed Properties of C22H17BrN2

A mixture of 4-bromo-4-trityl-1H-pyrazole (4.8 g, 12.3 mmol) described in Manufacturing Example 32-1-1, bis(pinacolate)diboran (5.0 g, 19.7 mmol), potassium acetate (3.62 g, 36.9 mmoL), 1,1′ bis(diphenylphosphino)ferrocene dichloropalladium(II) (450 mg, 0.62 mmol) and dimethyl sulfoxide (50 mL) was stirred under argon atmosphere for 17 hours and 10 minutes at 80 C. The reaction solution was allowed to room temperature, and partitioned into water and ethyl acetate. The organic layer was concentrated under a reduced pressure. The residue was purified by silica gel chromatography (heptane:ethyl acetate=4:1). Heptane was added to the solids obtained by concentrating the eluate under a reduced pressure, which were then irradiated by ultrasonic wave and filtered to obtain the title compound (1.51 g, 28.0%). 1H-NMR Spectrum (CDCl3) delta (ppm): 1.30 (12H, s), 7.10-7.16 (6H, m), 7.26-7.31 (9H, m), 7.75 (1H, s), 7.94 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-tritylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 95162-14-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95162-14-4 as follows.

Intermediate 12: Methyl [N- (TERT-BUTOXVCARBONYL)-4- (1-TRITYL-1H-PVRAZOL-4-VL)-L-PHENVLALANINATE] To a mixture of [BROMOPYRAZOLE] (11) (1. 0g, 2. [56MOL),] boronic acid (1) (0.7g, 2. [14MMOL),] and potassium carbonate (1.5g, 10. [7MMOL)] in degassed DME [(10ML)] was added [PDCI2 [DPPF]] (0.088g, [0.] [1MMOL).] The reaction mixture was then heated to [70C] under nitrogen for 24 hours. Solvent was then removed in vacuo, and the residue was partitioned between ethyl acetate and water. The organic portion was dried over sodium sulphate and solvent evaporated in vacuo to give the crude product. Purification via silica gel chromatography (ethyl acetate/petroleum ether 40-60 1: 4) gave the title compound (0.74g) LCMS RT 4.11 min, [[CPH3] + 243]

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2003/104200; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95162-14-4, name is 4-Bromo-1-tritylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-tritylpyrazole

To a 500 mL Schenk flask backfilled with N2was added 4-bromo-1-trityl-1H-pyrazole(10.0 g, 25.7 mmol) and dry THF (250 mL). The resulting suspension was cooledto -78 C under stirring. 1.6 M n-butyl lithium (20.0 mL, 32.0 mmol, 1.2equiv.) was then added dropwise, and the solution was left to stir for 30minutes before adding triisopropyl borate (7.4 mL, 32.0 mmol, 1.2 equiv.)dropwise. The resulting solution was stirred at 1 hour at -78 C and allowed toreach room temperature over 1 hour. Pinacol (3.9 g, 33.4 mmol, 1.3 equiv.) wasadded under stirring, and the solution was stirred for 30 minutes before addingglacial acetic acid (1.6 mL, 28.3 mmol, 1.1 equiv.). The suspension was stirredfor a further 30 minutes before removing the solvent in vacuo to yield awhite solid. Recrystallization was achieved by triturating the crude compoundin DCM (3 mL) and methanol (200 mL) over 1 hour. The resulting solid wascollected by filtration, washed with methanol and dried overnight at 50 C toyield 1-trityl-1H-pyrazol-4-ylboronatepinacol ester (9.1 g, 20.9 mmol, 81.4%) as a white solid. 1H NMR (500 MHz, CD2Cl2) delta = 1.28(s, 12H), 7.12 – 7.14 (m, 6H), 7.30 – 7.33 (m, 9H), 7.63 (d, J = 0.9 Hz, 1H),7.81 (d, J = 0.9 Hz,). 13CNMR (125 MHz, CD2Cl2) delta = 25.17, 79.22, 83.82, 128.25,130.72, 139.35, 143.82, 145.83. HRMS(ESI) Calcd for C28H29BN2O2 [M+H]: 437.239983;Found: 437.240521.

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kershaw Cook, Laurence J.; Kearsey, Rachel; Lamb, Jessica V.; Pace, Edward J.; Gould, Jamie A.; Tetrahedron Letters; vol. 57; 8; (2016); p. 895 – 898;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 95162-14-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 95162-14-4, name is 4-Bromo-1-tritylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A stirred mixture of 5.0 g (12.8 mmol) of 4-bromo-1-trityl-1H-pyrazole, 9.8 g (38.6 mmol, 3.0 eq.) of bis(pinacolato)diboron, 1.0 g (1.3 mmol, 10 mol %) of PdCl2(dppf) and 6.3 g (64.2 mmol, 5.0 eq) of potassium acetate in DMF (30 mL) was heated at 80 C. for 16 h. The resulting mixture was diluted with water, and the product was extracted with dichloromethane. The organic layer was washed with brine, dried over sodium sulfate, and purified by flash chromatography to give 5.1 g (91%) of 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-tritylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bentzien, Joerg Martin; Takahashi, Hidenori; US2008/261975; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 95162-14-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 95162-14-4, name is 4-Bromo-1-tritylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of bromopyrazole (5) (1. [0G,] 2. [56MOL),] [BORONIC ACID] (1) (0.7g, 2. [14MMOL),] and potassium carbonate (1.5g, 10. [7MMOL)] in degassed DME [(10ML)] was added [PDC12 [DPPF]] (0. 088g, [0.] [1MMOL).] The reaction mixture was then heated to [70C] under nitrogen for 24 hours. Solvent was then removed in vacuo, and the residue was partitioned between ethyl acetate and water. The organic portion was dried over sodium sulphate and solvent evaporated in vacuo to give the crude product. Purification via silica gel chromatography (ethyl acetate/petroleum ether 40-60 1: 4) gave the title compound (0.74g) LCMS [RT 4. 11 MIN, [CPH3] + 243]

The synthetic route of 4-Bromo-1-tritylpyrazole has been constantly updated, and we look forward to future research findings.

Related Products of 95162-14-4, A common heterocyclic compound, 95162-14-4, name is 4-Bromo-1-tritylpyrazole, molecular formula is C22H17BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2) Synthesis of 4- (4-fluorophenyl) -1-trityl-lH- pyrazole To a suspension of 4-bromo-trityl-l.H-pyrazole (0.7 g) in N, N-dimethylformamide (14 ml) was added 4- fluorophenylboronic acid (0.377 g) , cesium carbonate (1.758 g) , and tetrakis triphenylphosphine palladium (0.208 g) . The resulting suspension was stirred at room temperature for 10 min. The irradiation of microwaves at 1600C for 10 min was sufficient to complete a reaction in the suspension. The product was filtered through silica gel, diluted in ethyl acetate (30 ml) and washed with saturated ammonium chloride solution (30 ml) and then with brine (30 ml) . The washed organic layer thus formed was dried over anhydrous magnesium sulfate and concentrated by evaporation in a vacuum. The residue thus obtained was separated using silica gel chromatography to produce 4- (4-fluorophenyl) -1- trityl-lH-pyrazole (yield 51%) .1H-NMROOOMHZ, CDCl3): 57.93 (s, IH), 7.62 (s, IH), 7.36-7.29(m, HH), 7.21-7.18(m, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 95162-14-4, name is 4-Bromo-1-tritylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 95162-14-4, Application In Synthesis of 4-Bromo-1-tritylpyrazole

To a suspension of 4-bromo-trityl-1H-pyrazole (0.7 g) in N,N-dimethylformamide (14 ml) was added 4-fluorophenylboronic acid (0.377 g), cesium carbonate (1.758 g), and tetrakis triphenylphosphine palladium (0.208 g). The resulting suspension was stirred at room temperature for 10 min. The irradiation of microwaves at 160 C. for 10 min was sufficient to complete a reaction in the suspension. The product was filtered through silica gel, diluted in ethyl acetate (30 ml) and washed with saturated ammonium chloride solution (30 ml) and then with brine (30 ml). The washed organic layer thus formed was dried over anhydrous magnesium sulfate and concentrated by evaporation in a vacuum. The residue thus obtained was separated using silica gel chromatography to produce 4-(4-fluorophenyl)-1-trityl-1H-pyrazole (yield 51%).1H-NMR (300 MHz, CDCl3): delta7.93 (s, 1H), 7.62 (s, 1H), 7.36-7.29 (m, 11H), 7.21-7.18 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-tritylpyrazole, other downstream synthetic routes, hurry up and to see.