Category: 25016-20-0

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25016-20-0 as follows. Computed Properties of C5H6N2O2

A suspension of the acid (90 g, 0.71 mol) and DMF (1 drop) in thionyl chloride (250 mL) was stirred at reflux under nitrogen for 2 h. The solvent was evaporated from the reaction mixture, the residue azeotroped with toluene (3X200 mL), diluted into toluene (250 mL), added to a suspension OF PD-C (10 wtpercent, 9.3 g) in toluene (500 mL), and the mixture stirred at reflux for 8 h with a gentle flow of hydrogen gas through the suspension. After cooling to room temperature, the suspension was filtered through celite, washed with toluene, and concentrated in vacuo. The residue was fractionally distilled under vacuum to provide the title compound (50 g, 63percent) as a low melting white solid (bp = 92 ¡ãC COMMAT; 8 mmHg)

According to the analysis of related databases, 25016-20-0, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2

C2-Ocyclopropyl Boc protected amine macrocycle Am (75 mg, 0.093 mmol) is charged in a vial, then a 4 M solution of HCI in dioxane (1 ml_, 4 mmol) is added. The solution is stirred at RT for 1 .5 h, after which a precipitate forms. The solution is evaporated to dryness. 1 -methyl-1 H-pyrazole-3-carboxylic acid R2b (14.0 mg, 0.1 1 1 mmol) is dissolved in DCM (2 ml_), then TEA (51 .6 muIota_, 0.370 mmol) is added followed by TBTU (35.7 mg, 0.1 1 1 mmol). The solution is stirred for 15 mins, after which it is added to the amine hydrochloride in solution in DCM (1 ml_). The solution is stirred at RT for 16 h. The reaction is not complete so additional 1 -methyl-1 H pyrazole-3-carboxylic Acid R2b (3.5 mg, 0.028 mmol), TEA (13.0 muIota_, 0.092 mmol) followed by TBTU (8.9 mg, 0.028 mmol) are added. The solution is stirred at RT for 5 h, concentrated and then the residual is dissolved in DMSO. The resulting solution is filtered through a Millex filter and purified by prep HPLC (Sunfire column, ammonium formate and MeOH). The pure fractions are combined, concentrated, redissolved in MeCN and water, frozen and lyophilized to provide compound 1028. FIA M.S.(electrospray) : 818.4 (M+H)+ Retention time (min) = 5.5 min1H NMR (400 MHz,DMSO-d6): delta 10.80 (bs, 1 H), 8.93 (s, 1 H), 7.84 (d, 1 H, J = 8.9 Hz), 7.76 (d, 1 H, J = 2.4 Hz), 6.74-7.70 (m, 1 Hz), 7.10 (d, 1 H, J = 9.2 Hz), 6.59 (d, 1 H, J = 2.1 Hz), 6.38 (s, 1 H), 5.68-5.54 (m, 1 H), 5.47-5.40 (m, 1 H), 5.10-5.00 (m, 1 H), 4.68-4.56 (m 1 H), 4.50 (qn, 1 H, J = 3.2 Hz) 4.47-4.38 (m, 2H), 4.08-3.96 (m, 1 H), 3.89 (s, 3H), 3.88 (s, 3H), 2.66-2.58 (m, 1 H), 2.47 (s, 3H), 2.40-2.28 (m, 2H), 2.01 -1 .74 (m, 2H), 1 .64-1 .49 (m, 3H), 1 .48-1 .13 (m, 12H), 0.93-0.79 (m, 4H), 0.76- 0.69 (m, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-20-0.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 25016-20-0

Acid R2b (8.2 mg, 0.065 mmol, 1.3 equiv) is dissolved in DMF (0.5 mL), then TEA (35 muIota_, 0.25 mmol, 5.0 equiv) is added followed by TBTU (19 mg, 0.060 mmol, 1.2 equiv). The solution is stirred for 15 mins, after which the amine hydrochloride Da (37 mg, 0.050 mmol) is added in DMF (0.5 mL). The solution is stirred at RT for 16 h. Water (2 mL) is added and the organic layer is extracted with EtOAc (3 x5 mL). The solvent is then evaporated and purified on prep HPLC (MeCN:H20, 0.1% TFA). The pure fractions are combined, concentrated, frozen and lyophilized to provide compound 1003. FIA M.S.(electrospray): 806.4 (M+H)+ Retention time (min) = 5.5 min1H NMR (400 MHz,DMSO-d6): delta 11.03 (s, 1H) , 8.81 (s, 1H), 7.83 (d, 1H, J = 8.8 Hz), 7.78-7.74 (m, 2H), 7.08 (d, 1H, J = 9.3 Hz), 6.60 (d, 1H, J = 2.3 Hz), 6.37 (s, 1H), 5.67-5.58 (m, 1H), 5.53-5.42 (m, 2H), 5.14 (dd, 1H, J = 9.5, 9.2 Hz), 4.64-4.57 (m, 1H), 4.51 (d, 1H, J= 11.6 Hz), 4.38 (dd, 1H, J= 9.4, 7.0 Hz), 4.01 (dd, 1H, J = 11.8, 3.5 Hz), 3.89 (s, 3H), 3.88 (s, 3H), 2.96-2.88 (m, 1H), 2.65-2.57 (m, 1H), 2.44 (s, 3H), 2.40-2.28 (m, 2H), 2.00-1.89 (m, 1H), 1.88-1.77 (m, 1H), 1.62-1.51 (m, 3H), 1.50-1.33 (m, 11H), 1.31-1.19 (m, 2H), 1.14-0.98 (m, 4H).

The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.

Reference of 25016-20-0,Some common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of methyl 1-methyl-1H-pyrazole-3-carboxylate To a solution of 1-methyl-1H-pyrazole-3-carboxylic acid (504 mg, 4 mmol) in MeOH (5 mL) was added SOCl2 (1.4 mL, 20 mmol) at 0 C. The mixture was stirred at r.t overnight then concentrated under reduced pressure. The residue was dissolved in EtOAc, washed with satd. aq. NaHCO3 and concentrated to afford methyl 1-methyl-1H-pyrazole-3-carboxylate. LC-MS: m/z 141 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-3-carboxylic acid, its application will become more common.

Synthetic Route of 25016-20-0,Some common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2,3-dichlorophenyl)(5-aminoindol-1-yl)methanone (40 mg, 0.13 mmol, 1.0 equiv.), 1-A-1H-pyrazole-3-carboxylic acid (17 mg, 0.134 mmol, 1.05 equiv.), HATU (54 mg, 0.14 mmol, 1.1 equiv.),DIPEA (18 mg, 0.14 mmol, 1.1 equiv.) was dissolved in an appropriate amount of DCM and stirred at room temperature for 6 to 8 hours. The TLC monitors the reaction in real time. anti-After completion, the reaction solution was diluted with 2N HCl, and extracted with three portions of ethyl acetate. The organic phase was combined and then dissolved with water and saturated NaHCO3.Wash with liquid, saturated NaCl solution, and dry the organic layer with anhydrous NaSO4.Distilled under reduced pressure to obtain a crude product,Purified by silica gel column to obtain N-(1-(2,3-Dichlorobenzoyl)porphyrin-5-yl)-1-methyl-1H-pyrazole-3-carboxamide (40 mg, yield: 73.9%).

The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-20-0, Quality Control of 1-Methyl-1H-pyrazole-3-carboxylic acid

Step 3: To solution of step 2 intermediate (6.0 g, 47.6 mmol) in CH2CI2 (50 mL) were added oxalyl chloride (6.12 mL, 71.4 mmol) and catalytic amount of DMF (0.5 mL) at 0C. The RM was stirred at rt for 2 h. The RM was concentrated under reduced pressure and residue was diluted with CH2CI2. NH3 gas was passed through RM at 0C for 30 min. After that the RM was concentrated under reduced pressure and residue was suspended in THF (50 ml) and filtered. The filtrate was concentrated under reduced pressure to yield the desired compound (3.5 g, 59%). LC-MS (Method 3): m/z [M+H]+ = 126 (MW calc. = 125.13); R, = 0.76 min.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 25016-20-0

To a solution of 1 -methyl- 7/-/-pyrazole-3-carboxylic acid (0.100 g, 0.793 mmol), A/,A/-diisopropylethylamine (0.307 g, 2.38 mmol) in tetrahydrofuran (4 ml_) at 20 C was added 1 -[b/s(dimethylamino)methylene]- 7/-/-1 ,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (0.452 g, 1 .19 mmol). The reaction was stirred for 20 minutes before a solution of 5-(3-chlorobenzyl)pyridin-2-amine (0.173 g, 0.793 mmol) in tetrahydrofuran (1 .0 ml_) was added. The solution was stirred at 20 C for 16 h. The volatiles were removed under reduced pressure and the residue was added to a mixture of dichloromethane (50 ml_) and water (50 ml_). The organic layer was collected, dried over sodium sulfate, filtered and concentrated. The crude sample was dissolved in minimal A/,A/-dimethylformamide and purified via prep-HPLC (Boston C1 8 21 *250 mm 10 pm column; acetonitrile/0.01 % aqueous trifluoroacetic acid) to give A/-(5-(3-chlorobenzyl)pyridin-2-yl)-1 -methyl- 7/-/-pyrazole-3-carboxamide (0.0927 g, 0.285 mmol, 36%) as a white solid. 1 H NMR (400 MHz, Dimethylsulfoxide-c/6) d 9.51 (s, 1 H), 8.29 (s, 1 H), 8.1 0 (d, J = 10.5 Hz, 1 H), 7.88 (d, J = 2.5 Hz, 1 H), 7.71 -7.74 (m, 1 H), 7.23-7.35 (m, 4H), 6.84 (d, J = 2.5 Hz, 1 H), 3.96 (s, 5H); LCMS (ESI) m/z: 327.1 [M+H]+.

The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.