Category: 13808-64-5

The important role of 4-Bromo-3-methylpyrazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.

13808-64-5, Adding a certain compound to certain chemical reactions, such as: 13808-64-5, name is 4-Bromo-3-methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13808-64-5.

To a solution of 4-bromo-3 -methyl- lH-pyrazole 1 (0.25 g, 1.55 mmol) indimethylformamide (DMF) (30 mL) was added NaH (0.08 g, 3.2 mmol). The mixture was stirred for 0.5 h at room temperature and 2-bromo-5-methyl-l,3-thiazole (0.33 g, 1.86 mmol) was added. The reaction mixture was stirred for 1 h at room temperature. The reaction temperature was raised to 90C and stirred overnight. The reaction was quenched with MeOH and solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over Na2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 53 (0.2 g, 50%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.

The important role of 4-Bromo-3-methylpyrazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.

13808-64-5, Adding a certain compound to certain chemical reactions, such as: 13808-64-5, name is 4-Bromo-3-methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13808-64-5.

To a solution of 4-bromo-3 -methyl- lH-pyrazole 1 (0.25 g, 1.55 mmol) indimethylformamide (DMF) (30 mL) was added NaH (0.08 g, 3.2 mmol). The mixture was stirred for 0.5 h at room temperature and 2-bromo-5-methyl-l,3-thiazole (0.33 g, 1.86 mmol) was added. The reaction mixture was stirred for 1 h at room temperature. The reaction temperature was raised to 90C and stirred overnight. The reaction was quenched with MeOH and solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over Na2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 53 (0.2 g, 50%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-methylpyrazole, other downstream synthetic routes, hurry up and to see.