Category: 19959-77-4

Some common heterocyclic compound, 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 19959-77-4

Solid HL (15.9 mg, 0.10 mmol) and CuCl22H2O (16.8 mg,0.10 mmol) were separated into two arms of an H-tube, whichwas filled with ethanol or acetone solution and subsequentlysealed with thin film. Dark blue block crystals of complex 1 wereobtained after two weeks. The crystals were washed with n-hexane2 3 times, then dried in a vacuum. Yield: 27.3 mg (53%). M.p.>300 C. Anal. Calc. for C18H16N6Cl2Cu2 (FW, 514.3): C, 42.03; H,3.14; N, 16.34. Found: C, 42.34; H, 3.54; N, 16.28%. Selected IR data(cm-1, KBr): 3525 (b, s); 3080 (w); 2923 (w); 1610 (vs m(CN));1565 (m, m(CC)); 1492 (m); 1457 (vs d(CH3)); 1400 (m); 1336(m); 1285 (m); 1177 (m); 1152 (m); 1115 (m); 1088 (m); 1053(m); 985 (m); 897 (m); 782 (vs); 748 (m); 683 (m); 648 (m); 532(w).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 19959-77-4, its application will become more common.

Reference:
Article; Yang, Feng-Lei; Zhu, Guang-Zhou; Liang, Bei-Bei; Shi, Yan-Hui; Li, Xiu-Ling; Polyhedron; vol. 128; (2017); p. 104 – 111;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

To a solution of 2-(5-methyl-1H-pyrazol-3-yl)pyridine (27.9 g, 175 mmol) in carbon tetrachloride (300 mL) and dicholoromethane (300 mL) in a round-bottom flask was added N-bromosuccunimide (31.2 g, 175 mmol). The resulting mixture was stirred at room temperature for 21 hours and the reaction mixture was added water. The resulting solution was extracted with dicholomethane. The organic extracts were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid was washed with hexane/AcOEt (v/v =10/1) and dried under reduced pressure at 50 C. The title compound was obtained as a white solid. (37.5 g, 158 mmol, 90% yield): 1H NMR (400 MHz, CDCl3) d 8.61 (d, J = 3.1 Hz, 1H), 8.28 (d, J = 7.8 Hz, 1H), 7.80 (t, J = 7.8 Hz, 1H), 7.28 (t, J = 7.8 Hz, 1H), 2.34 (s, 3H).

According to the analysis of related databases, 19959-77-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Fukuda, Takeshi; Goto, Riki; Kiho, Toshihiro; Ueda, Kenjiro; Muramatsu, Sumie; Hashimoto, Masami; Aki, Anri; Watanabe, Kengo; Tanaka, Naoki; Bioorganic and Medicinal Chemistry Letters; vol. 27; 16; (2017); p. 3716 – 3722;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

General procedure: Solid HL (15.9 mg, 0.10 mmol) and CuCl22H2O (16.8 mg,0.10 mmol) were separated into two arms of an H-tube, whichwas filled with ethanol or acetone solution and subsequentlysealed with thin film. Dark blue block crystals of complex 1 wereobtained after two weeks. The crystals were washed with n-hexane2 3 times, then dried in a vacuum.

According to the analysis of related databases, 19959-77-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yang, Feng-Lei; Zhu, Guang-Zhou; Liang, Bei-Bei; Shi, Yan-Hui; Li, Xiu-Ling; Polyhedron; vol. 128; (2017); p. 104 – 111;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19959-77-4 as follows. Computed Properties of C9H9N3

A 5mL ethanol solution of L (0.1mmol, 15.9mg), hydrazine hydrate (0.1mmol, 5mg) and Et3N (0.1mmol, 14mul) was mixed with a 5mL ethanol solution of NiCl2·6H2O (0.05mmol, 11.9mg), and the resulting mixture was then stirred for 15min to obtain a light-green solution. This resulting solution was filtered and left to evaporate for three days, giving rise to light-blue block crystals of 2. The resulting crystals were washed with n-hexane 2?3 times, then dried in vacuum. Yield: 26.4mg (53%), M. p. >300C. Anal. Calc. for C18H24Cl2N7NiO2 (FW, 500.05): C, 43.37; H, 4.86; N, 19.68. Found: C, 43.54; H, 4.96; N, 19.18%. Selected IR data (cm-1, KBr): 3350 (b, m), 3250 (b, s), 3130 (s), 3066 (s), 2969 (s), 2863 (s), 1610 (m) (nu(C=N)), 1573 (m) (nu(C=C)), 1443 (s) (delta(CH3)), 1304 (m) (nu(C-N)), 1256 (w), 1116 (w), 1054 (w), 1021(w), 985 (m), 789 (s).

According to the analysis of related databases, 19959-77-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhu, Guang-Zhou; Xing, Bei-Bei; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 81; (2014); p. 705 – 714;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, A new synthetic method of this compound is introduced below., Computed Properties of C9H9N3

A 5mL methanol solution of L (0.2mmol, 31.8mg) and m-phthalic acid (0.2mmol, 33.2mg) was mixed with a 5mL methanol solution of Mn(HCOO)2·2H2O (0.1mmol, 14.5mg), and the resulting mixture was then stirred 15min to obtain a colorless solution. This colorless solution was filtered and left to evaporate for one week, giving rise to colorless stick-like crystals. The resulting crystals were washed with n-hexane 2?3 times, then dried in vacuum. Yield: 47.1mg (67%), M. p. > 300C. Anal. Calc. for C34H28MnN6O8 (FW, 703.56): C, 58.04; H, 4.01; N, 11.95. Found: C, 58.98; H, 4.73; N, 11.49%. Selected IR data (cm-1, KBr): 3256 (b, s), 3128 (m), 3073 (m), 2925 (m), 2883 (m), 1694 (s) (nu(C=O)), 1606 (m) (nu(C=N)), 1561 (s) (nu(C=C)), 1428 (m) (delta(CH3)), 1392 (s), 1296 (m) (nu(C-N)), 1161 (w), 777 (m), 733 (m), 689 (m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhu, Guang-Zhou; Xing, Bei-Bei; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 81; (2014); p. 705 – 714;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

A 5mL ethanol solution of L (0.2mmol, 15.9mg) and Et3N (0.1mmol, 14mul) was mixed with a 5mL ethanol solution of ZnCl2 (0.1mmol, 13.6mg), and the resulting mixture was then stirred for 15min to obtain a colorless solution. This colorless solution was filtered and left to evaporate for three days, giving rise to colorless rod-like crystals. The resulting crystals were washed with n-hexane 2?3 times, then dried in vacuum. Yield: 23.6mg (80%), M. p. >300C. Anal. Calc. for C9H9Cl2N3Zn (FW, 295.46): C, 36.58; H, 3.07; N, 14.22. Found: C, 36.08; H, 3.53; N, 13.79%. Selected IR data (KBr, cm-1): 3175(s), 3133 (s), 3109 (m), 3087 (m), 2924 (s), 2853 (s), 1611 (m) (nu(C=N)), 1573 (m) (delta(C=C)), 1446 (s) (nu(CH3)), 1303 (m) (nu(C-N)), 1261 (w), 1114 (w), 1053 (w), 1023(w), 988 (s), 823 (m), 793 (s), 738 (m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19959-77-4.

Reference:
Article; Zhu, Guang-Zhou; Xing, Bei-Bei; Yang, Feng-Lei; Li, Xiu-Ling; Polyhedron; vol. 81; (2014); p. 705 – 714;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Complex 3 could be obtained by two methods:Method 1: using the diffusion method as for the above mentionedcompounds; solid HL (14.5 mg, 0.10 mmol) and Cu(CH3-COO)2H2O (19.9 mg, 0.10 mmol) were separated into two armsof an H-tube, which was filled with acetonitrile as the solvent system.Two weeks later, black-green block crystals of compound 3were obtained.Method 2: using the solvothermal method; HL (15.9 mg,0.10 mmol) and Cu(CH3COO)2H2O (19.9 mg, 0.10 mmol) were dissolvedin acetone (10 mL), to which NEt3 (14 muL, 0.1 mmol) wasadded dropwise under stirring. The resultant green solution wascontinuously stirred for an additional 10 min, then transferred intoa 25 mL Teflon-lined autoclave and heated at 140 C for 3 days. Theresultant clear solution was filtered, then left to evaporate for threedays to give black-green block crystals of 3. The crystals werewashed with n-hexane 2 3 times, then dried in a vacuum. Yield:26.9 mg (48%), M.p. >300 C. Anal. Calc. for C22H22N6O4Cu2 (FW,561.54): C, 47.06; H, 3.95; N, 14.97. Found: C, 47.34; H, 3.89; N,14.71%. Selected IR data (cm-1, KBr): 3422 (br); 2926 (w); 1611(s) (m(CN)); 1584 (s) (m(CC)); 1497 (w); 1462 (s) (d(CH3));1391 (w); 1335 (s); 1184 (w); 1050 (w); 988 (w); 779 (s); 749(w); 683 (m); 620 (w) (see Scheme 2).

The synthetic route of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Feng-Lei; Zhu, Guang-Zhou; Liang, Bei-Bei; Shi, Yan-Hui; Li, Xiu-Ling; Polyhedron; vol. 128; (2017); p. 104 – 111;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

Solid ligand L (0.2mmol, 31.8mg) and Cd(NO3)2·4H2O (0.1mmol, 30.8mg) were placed into the bottom of separate arms of an H-tube. The H-tube was filled with acetonitrile solution and sealed with plastic film. After one week, colorless stick-like crystals of compound 4 were generated and collected, washed with n-hexane 2-3 times, then dried in vacuum. Yield: 42.72mg (77%), M. p. > 300C. Anal. Calc. for C18H18CdN8O6 (FW, 554.8): C, 38.97; H, 3.27; N, 20.20. Found: C, 38.31; H, 3.39; N, 19.70%. Selected IR data (cm-1, KBr): 3200 (b, s), 3135 (s), 2994 (s), 2853 (m), 2363 (s), 1607 (m) (nu(C=N)), 1578 (m) (nu(C=C)), 1435 (s), 1387 (s), 1340 (m), 1301 (m), 1225 (w), 1156 (w), 1111 (w), 1018 (w), 980 (s), 797 (s), 740 (m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

The chemical industry reduces the impact on the environment during synthesis 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, I believe this compound will play a more active role in future production and life. 19959-77-4

To a solution of 2-(5-methyl-1H-pyrazol-3-yl)pyridine (27.9 g, 175 mmol) in carbon tetrachloride (300 mL) and dicholoromethane (300 mL) in a round-bottom flask was added N-bromosuccunimide (31.2 g, 175 mmol). The resulting mixture was stirred at room temperature for 21 hours and the reaction mixture was added water. The resulting solution was extracted with dicholomethane. The organic extracts were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid was washed with hexane/AcOEt (v/v =10/1) and dried under reduced pressure at 50 C. The title compound was obtained as a white solid. (37.5 g, 158 mmol, 90% yield): 1H NMR (400 MHz, CDCl3) d 8.61 (d, J = 3.1 Hz, 1H), 8.28 (d, J = 7.8 Hz, 1H), 7.80 (t, J = 7.8 Hz, 1H), 7.28 (t, J = 7.8 Hz, 1H), 2.34 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 19959-77-4. I believe this compound will play a more active role in future production and life.

The chemical industry reduces the impact on the environment during synthesis 19959-77-4, name is 2-(5-Methyl-1H-pyrazol-3-yl)pyridine, I believe this compound will play a more active role in future production and life. 19959-77-4

To a solution of 2-(5-methyl-1H-pyrazol-3-yl)pyridine (27.9 g, 175 mmol) in carbon tetrachloride (300 mL) and dicholoromethane (300 mL) in a round-bottom flask was added N-bromosuccunimide (31.2 g, 175 mmol). The resulting mixture was stirred at room temperature for 21 hours and the reaction mixture was added water. The resulting solution was extracted with dicholomethane. The organic extracts were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid was washed with hexane/AcOEt (v/v =10/1) and dried under reduced pressure at 50 C. The title compound was obtained as a white solid. (37.5 g, 158 mmol, 90% yield): 1H NMR (400 MHz, CDCl3) d 8.61 (d, J = 3.1 Hz, 1H), 8.28 (d, J = 7.8 Hz, 1H), 7.80 (t, J = 7.8 Hz, 1H), 7.28 (t, J = 7.8 Hz, 1H), 2.34 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 19959-77-4. I believe this compound will play a more active role in future production and life.