Category: 19959-77-4

Tris(pyrazolyl)borate Copper Hydroxide Complexes Featuring Tunable Intramolecular H-Bonding was written by Gardner, Evan J.;Cobb, Caitlyn R.;Bertke, Jeffery A.;Warren, Timothy H.. And the article was included in Inorganic Chemistry in 2019.Product Details of 19959-77-4 This article mentions the following:

A modular synthesis provides access to new tris(pyrazolyl)borate ligands ^XpyMeTpK that possess a single functionalized pendant pyridyl (py) or pyrimidyl (pyd) arm designed to engage in tunable intramol. H-bonding to metal-bound functionalities. To illustrate such H-bonding interactions, [^XpyMeTpCu]₂(娓?OH)₂ (6a–6e) complexes were synthesized from the corresponding ^XpyMeTpCu-OAc (5a–5e) complexes. Single crystal x-ray structures of three new dinuclear [^XpyMeTpCu]₂(娓?OH)₂ complexes reveal H-bonding between the pendant heterocycle and bridging hydroxide ligands while the donor arm engages the Cu center in an unusual monomeric ^DMAPMeTpCu-OH complex. Vibrational studies (IR) of each bridging hydroxide complex reveal reduced 璋?sub>OH frequencies that tracks with the H-bond accepting ability of the pendant arm. Reversible protonation studies that interconvert [^XpyMeTpCu]₂(娓?OH)₂ and [^XpyMeTpCu(OH₂)]OTf species indicate that the acidity of the corresponding aquo ligand decreases with increasing H-bond accepting ability of the pendant arm. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Product Details of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electronic effects in the catalytic hydrosilylation with in-situ generated iron(II)-catalysts was written by Muller, Keven;Schubert, Anett;Jozak, Thomas;Ahrens-Botzong, Annegret;Schuenemann, Volker;Thiel, Werner R.. And the article was included in ChemCatChem in 2011.Electric Literature of C9H9N3 This article mentions the following:

In combination with different aromatic N,N-donors, iron acetate and octanoate are suitable catalyst precursors for the hydrosilylation of carbonyl compounds Iron octanoate can be used to perform this catalytic transformation in cheap and non-toxic petrol ether or heptane as the solvent and with versatile polymethylhydrosiloxane (PMHS) as the silane source. Investigation of the performed catalyst (iron octanoate + N,N-ligand + PMHS) by using Moessbauer spectroscopy suggests that the active species is a high-spin iron(II) system. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Electric Literature of C9H9N3).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Electric Literature of C9H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyridine-pyrazole compound as inhibitor for steel in 1M HCl was written by Bouklah, M.;Attayibat, A.;Hammouti, B.;Ramdani, A.;Radi, S.;Benkaddour, M.. And the article was included in Applied Surface Science in 2005.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

The influence of 3,5-dimethyl-1H-pyrazole, pyridine and 2-(3-methyl-1H-pyrazol-5-yl) pyridine (P3) on the corrosion inhibition of carbon steel in 1M HCl solution was studied by using weight-loss, potentiodynamic and EIS measurements. P3 was the best inhibitor, and its inhibition efficiency increases with increasing inhibitor concentration to attain 89% at 10^-3 M. Potentiodynamic polarization studies clearly reveal that it acts essentially as a cathodic inhibitor. The inhibitor decreased the corrosion rates. The efficiency values obtained by the various methods used were in agreement. Adsorption of P3 on the steel surface has an S-shaped adsorption isotherm. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Novel η³-Allylpalladium-Pyridinylpyrazole Complex: Synthesis, Reactivity, and Catalytic Activity for Cyclopropanation of Ketene Silyl Acetal with Allylic Acetates was written by Satake, Akiharu;Nakata, Tadashi. And the article was included in Journal of the American Chemical Society in 1998.Application of 19959-77-4 This article mentions the following:

Novel cationic η³-allylpalladium-pyridinylpyrazole complexes I (R = Me, Bu^t) were synthesized from 3-alkyl-5-(2-pyridinyl)pyrazole and η³-allylpalladium chloride dimer in the presence of AgBF₄. Cationic complexes I were converted into neutral complexes II under basic conditions. These complexes were characterized by ¹H, ¹³C, and ¹⁵N NMR studies. Neutral complexes II have high catalytic activity for cyclopropanation of ketene silyl acetals with allylic acetates. Comparison of the cationic and neutral complexes and the reaction mechanism of cyclopropanation were discussed. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Application of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Penta- and dinuclear carboxylate nickel(II) complexes with pyrazole-based ligands: Syntheses, magnetic properties and DFT calculations was written by Nikiforov, Alexey A.;Dubrov, Evgenii N.;Blinou, Daniil O.;Gurzhiy, Vladislav V.;Selyutin, Artem A.;Klyukin, Ilya N.;Zhdanov, Andrey P.;Minkovich, Alexander E.;Panina, Natalia S.;Eremin, Alexei V.. And the article was included in Polyhedron in 2021.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

<<One pot>> reactions of pyrazole-based ligands Hdmpz and PyPz with in situ formed carboxylate precursors led to the formation of mono- and di-aqua-bridged binuclear compounds, as well as pentanuclear hydroxo-bridged compound: [Ni₂(μ-OH₂)(μ-O₂CC(CH₃)₃)₂(O₂CC(CH₃)₃)₂(PyPz)₂] (1), [Ni₅(μ₃-OH)₂(μ-O₂CPh)₈(PyPz)₄]^.4.73MeCN (2), [Ni₂(μ-OH₂)(μ-O₂CPh)₂(O₂CPh)₂(Hdmpz)₄] (3), [Ni₂(μ-OH₂)₂(μ-O₂CPh)(O₂CPh)₂(Hdmpz)₄](O₂CPh)•2.5H₂O (4) (Hdmpz = 3,5-dimethylpyrazole, PyPz = 2-(5-Methyl-1H-pyrazol-3-yl)pyridine). Compounds were characterized by structural and spectral methods, thermogravimetric anal. and magnetic measurements were also performed. It was noted, that structural motif of forming compounds are determined by the structure of carboxylate precursors formed in situ and properties of N-ligands. Comparison of magnetic measurements data, structural data, and DFT calculations allows us to conclude that in the case of investigated compounds the equilibrium between spin isomers with different multiplicities, close energy values and close geometrical structure (no data) can be realized. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

High efficiency electroluminescence of orange-red iridium(III) complexes for OLEDs with an EQE over 30% was written by Su, Ning;Li, Shuaibing;Yang, Kun;Zhou, Feifan;Song, Jun;Zhou, Liang;Qu, Junle. And the article was included in Dyes and Pigments in 2021.Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

In this study, three pyrazol-pyridine ligands, 2-(3-methyl-1H-pyrazol-5-yl)pyridine (mepzpy), 2-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine (cf3pzpy), and 2-(3-phenyl-1H-pyrazol-5-yl)pyridine (phpzpy) were successfully synthesized for three orange-red iridium (III) complexes Ir₁, Ir₂, and Ir₃, resp., in which (2,6-bis(trifluoromethyl)pyridin-4-yl)isoquinoline (BTPIQ) was applied as main ligand. Their single crystals were obtained by vacuum sublimation. They showed distinct photoluminescent emissions at 583 nm with a shoulder peak at 624 nm, with high phosphorescence quantum yields of up to 89%. Organic light-emitting devices (OLEDs) with these complexes as emitters exhibits good performances. Especially, the device with Ir₃ complex achieves the best performance with a maximum luminance of 24,188 cd m^-2, and a highest external quantum efficiency of 30.65%. This research proved that Ir(III) complexes show highly enhanced performance by the modification of electro-donating benzene ring group into ancillary ligands, which also offers us an efficient strategy to obtain high efficiency orange-red Ir(III) complexes for OLEDs. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Name: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Three Modes of Proton Transfer in One Chromophore: Photoinduced Tautomerization in 2-(1H-Pyrazol-5-yl)Pyridines, Their Dimers and Alcohol Complexes was written by Vetokhina, Volha;Dobek, Krzysztof;Kijak, Michal;Kaminska, Izabela I.;Muller, Keven;Thiel, Werner R.;Waluk, Jacek;Herbich, Jerzy. And the article was included in ChemPhysChem in 2012.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

Studies of 2-(1H-pyrazol-5-yl)pyridine (PPP) and its derivatives 2-(4-methyl-1H-pyrazol-5-yl)pyridine (MPP) and 2-(3-bromo-1H-pyrazol-5-yl)pyridine (BPP) by stationary and time-resolved UV/Vis spectroscopic methods, and quantum chem. computations show that this class of compounds provides a rare example of mols. that exhibit three types of photoreactions: (1) excited-state intramol. proton transfer (ESIPT) in the syn form of MPP, (2) excited-state intermol. double-proton transfer (ESDPT) in the dimers of PPP in nonpolar media, as well as (3) solvent-assisted double-proton transfer in hydrogen-bonded 1:1 complexes of PPP and MPP with alc. partners. The excited-state processes are manifested by the appearance of a dual luminescence and a bimodal irreversible kinetic coupling of the two fluorescence bands. Ground-state syn-anti equilibrium are detected and discussed. The fraction of the higher-energy anti form varies for different derivatives and is strongly dependent on the solvent polarity and hydrogen-bond donor or acceptor abilities. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A general and practical bifunctional cobalt catalytic system for N-heterocycle assembly via acceptorless dehydrogenation was written by Tian, Haitao;Xue, Wenxuan;Wu, Jingtao;Yang, Ziguang;Lu, Hongcheng;Tang, Conghui. And the article was included in Organic Chemistry Frontiers in 2022.Reference of 19959-77-4 This article mentions the following:

A novel and highly-efficient N-heterocycle assembly methodol. catalyzed by a cobalt-N,N-bidentate complex had been established. The cobalt complex was unprecedented, phosphine-free and easily-prepared, and was used in the synthesis of pyrimidines such as I [R = NH₂, Ph; Ar¹ = Ph, 2-MeOC₆H₄, 2-naphthyl, etc.; Ar² = Ph, 2-thienyl, 4-MeC₆H₄, etc.], quinolines such as II [R¹ = H, 8-Me; R² = H, Me; R³ = t-Bu, Ph, 2-naphthyl, etc.], imidazoles III [R⁴ = H, Me; R⁵ = H, Me, Cl; R⁶ = H, Me, Cl; R⁵R⁶ = CH=CH-CH=CH; Ar³ = Ph, 2-MeC₆H₄, 3-ClC₆H₄, etc.], quinoxalines such as IV [R⁷ = H, 5-Me, 6,7-di-Me, 6,7-di-Cl] and indole from readily available alcs. and amines via acceptorless dehydrogenation. More importantly, all N-heterocycles were obtained under nearly identical reaction conditions, which further demonstrated the generality and practicability of the catalytic system. Mechanistically, this cobalt complex formed a catalytic active species upon base treatment and was capable of realizing the alc. AD process via metal-ligand cooperation. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Reference of 19959-77-4).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Reference of 19959-77-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Excited-State Intramolecular Proton Transfer in Five-Membered Hydrogen-Bonding Systems: 2-Pyridyl Pyrazoles was written by Yu, Wei-Shan;Cheng, Chung-Chih;Cheng, Yi-Ming;Wu, Pei-Chi;Song, Yi-Hwa;Chi, Yun;Chou, Pi-Tai. And the article was included in Journal of the American Chemical Society in 2003.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

The excited-state intramol. proton transfer (ESIPT) reaction in five-membered N-H···N hydrogen-bonding systems has been explored through design and syntheses of a series of 5-(2-pyridyl)-1-H-pyrazoles. The ESIPT mechanism was confirmed through spectroscopy, relaxation dynamics, and corresponding methylated analogs. The results demonstrate for the first time a unique system among ESIPT mols., in which ESIPT incorporates an appreciably large energy barrier fine-tuned by the skeletal reorganization. This makes 5-(2-pyridyl)-1-H-pyrazole systems ideal models for probing the reaction potential energy surface. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Recommanded Product: 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics