Category: 155377-19-8

These common heterocyclic compound, 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H7F3N2O2

Example 119: Preparation of l-(prop-2-yl)-3-trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester and 2-(prop-2-yl)-3-trifluoromethyl-2H-pyrazole-4-carboxylic acid ethyl ester3-Trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester (2.5 g, 1.2 mmol) was dissolved in acetonitrile (25 ml) and stirred at room temperature. To the solution was added 2-iodopropane (1.8 ml, 1.8 mmol), followed by potassium carbonate (2.488 g, 1.8 mmol). The reaction mixture was heated to reflux and stirred for 6.5 hours. The reaction mixture was stored at room temperature for 16 hours. The reaction mixture was poured into water and extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate and concentrated to give l-(prop-2-yl)-3- trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester (isomer A) and 2-(prop-2-yl)- 3-trifluoromethyl-2H-pyrazole-4-carboxylic acid ethyl ester (isomer B) (9:1 mixture) as a yellow oil which was purified by column chromatography on silica gel (eluent: 0-10% ethyl acetate in hexane). Isomer A was obtained as a white solid (1.724 g, 57% yield). 1H-NMR (400 MHz, CDCl3): 1.35 (t, 3H, Me), 1.55 (d, 6H, Me), 4.3 (q, 2H, CH2), 4.55 (m, IH, CH), 8.0 (s, IH, CH) ppm.

The synthetic route of Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

155377-19-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below.

Example 12 Ethyl 1-(5-iodo-2-isopropylthio-6-trifluororethylpyrimidin-4-yl)-3-trifluoromethyl-1H-pyrazol-4-carboxylate 4-Chloro-5-iodo-2-isopropylthio-6-trifluoromethylpyrimidine (0.30 g) was dissolved in dimethylsulfoxide (3.0 ml) and ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate (0.16 g) and 1,8-diazabicyclo-[5,4,0]-under-7-ene (0.12 g) was added at room temperature with stirring. The mixture was heated to 80 C. and stirred for 2 hr. After cooling to room temperature, the mixture was added water and extracted with benzene. The benzene layer was washed with water and brine, respectively and dried over magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give ethyl 1-(5-iodo-2-isopropylthio-6-trifluoromethylpyrimidin-4-yl)-3-trifluoromethyl-1H-pyrazole-4-carboxylate (0.30 g) as colorless crystalline solid, mp 107-108 C.

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