Category: 143426-52-2

143426-52-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 143426-52-2 name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4 mmol of the compound IIIb was dissolved in 20 mL of acetonitrile, and intermediate 77 mmol and 8 mmol ofcesium carbonatewere added thereto at room temperature.After heating, the reaction was refluxed for 13 hours.The reaction was stopped, the reaction solution was rotary evaporated to dryness under reduced pressure, the resulting residue was purified by columnseparation and purification to give the title compound analysis Ib

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, and friends who are interested can also refer to it.

143426-52-2, The chemical industry reduces the impact on the environment during synthesis 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of methyl 2-fluoro-3,4-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (0.51 g), 1-(4-(chloromethyl)phenyl)-1H-pyrazole (0.48 g), tetrakis(triphenylphosphine)palladium(0) (0.096 g), 2 M aqueous sodium carbonate solution (1.7 mL), and DME (17 mL) was stirred under a nitrogen atmosphere at 90C for 15 hr. After cooling, the reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.35 g). MS: [M+H]+ 339.1

The chemical industry reduces the impact on the environment during synthesis 1-(4-(Chloromethyl)phenyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.