Category: 162758-35-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

Step 1: N-butanoyl-N’-[5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl]-hydrazine Added to a solution of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (0.40 g, 1.05 mmol), N-butanoyl-hydrazine (0.11 g, 1.05 mmol) and EDCI (0.24 g, 1.26 mmol) dissolved in DCM (11 ml), was DMAP (0.15 g, 1.26 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 6 hrs, and then treated with 10% aq. HCl. The organic layer was collected, and evaporated under a vacuum. The crude mixture was further purified by preparative HPLC, to obtain 0.38 g (0.81 mmol, 77%) of the title compound as yellow solid. 1H NMR (400 MHz, CDCl3) delta 7.40 (br s, 1H), 7.31-7.27 (m, 4H), 7.08-7.03 (m, 2H), 2.33 (s, 3H), 2.31 (t, J=7.8 Hz, 2H), 1.72 (m, 2H), 0.97 (t, J=7.3 Hz, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 162758-35-2.

Related Products of 162758-35-2, A common heterocyclic compound, 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, molecular formula is C17H11Cl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 5 5-(4-Chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride A solution of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (1.50 g, 3.94 mmol) in dry toluene (80 mL) was treated with thionyl chloride (0.6 mL, 8.22 mmol) under nitrogen, and heated at reflux for 3.5 hours. The solvent was removed under reduced pressure to afford the title compound (1.52 g, 97%).

The synthetic route of 162758-35-2 has been constantly updated, and we look forward to future research findings.

Related Products of 162758-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 162758-35-2 name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of carboxylic acid in CH2Cl2 (0.1 M) at rt. was added (COCl)2(3 eq) and a catalytic amount of DMF (1 drop). The mixture was then stirred for 1 h and concentratedin vacuo. The resultant crude acid chloride was dissolved in CH2Cl2 then DIPEA (6 eq) and the amine(1.5 eq) were added. The mixture was stirred at rt. for a further 16 h, washed with H2O three times,dried over Mg2SO4, filtered, and concentrated in vacuo. The resultant crude oil was then purified byflash chromatography to give the amide product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

A common compound: 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 162758-35-2

To a solution of the compound NDS-100226 (76 mg, 0.20 mmol)in dry dichloromethane, was added N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC.HC1, 40 mg, 0.26 mmol), Hydroxybenzotriazole (HOBt, 35 mg, 0.26 mmol) and diisopropylethyl amine (0.1 mL, 0.60 mmol) at 0C. Then the amine 3 was added and stirred at RT for 6 h. To the reaction mixture water was added and the organic layer was separated, washed with saturated NaHC03, IN HQ, dried over Na2S04 and concentrated under reduced pressure. This crude mixture was purified by column chromatography to give the title compound NDS-100240 (90 mg) as a white fluffy solid in 89% yield. NMR (400 MHz, CDQ3): delta 7.44 (d, J = 1.8 Hz, 1H), 7.32-7.29 (m, 4H), 7.06 (d, J = 8.3 Hz, 2H), 3.21 (t, J = 6.0 Hz, 411), 2.37 (s, 3H), 0.97 (t, J = 6.3 Hz, 4H), 0.10 (s, 6H) ); 13C NMR (100 MHz, CDC13): 6 159.9, 144.4, 142.9, 135.9 (2C), 134.9, 132.9, 130.8 (2C), 130.5, 130.3, 128.9 (2C), 127.8, 127.2, 1 18.2, 55.4, 13.2, 9.3, -3.5 (2C).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 162758-35-2, other downstream synthetic routes, hurry up and to see.

162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 162758-35-2

General procedure: To a mixture of carboxylic acid (1 mmol), EDC¡¤HCl (1.2 mmol) and HOBt (1.2 mmol) in dry dichloromethane (10 mL) was added a mixture of amine (1 mmol) and triethyl amine (1.5 mmol) in dichloromethane (5 mL) at 0 C. The mixture was stirred at room temperature till the completion of reaction (judged by TLC). The reaction mixture was diluted with additional DCM (20 mL). The organic layer was washed with water, brine and dried (Na2SO4). Concentration and purification over silica gel (100-200 mesh) afforded the desired compound.

Statistics shows that 162758-35-2 is playing an increasingly important role. we look forward to future research findings about 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid.