Category: 180207-57-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, This compound has unique chemical properties. The synthetic route is as follows., Formula: C5H8N2O

General procedure: KMnO4 (42.7 g, 0.27 mol) was added in small portions to asolution (in case of compounds 4a-c) or suspension (incase of compound 4d) of alcohol 4 (0.1 mol) and K2CO3 (5 g)in H2O (200 ml) at 70 during 1 h. The mixture washeated with stirring at 80 for 3 h, cooled to room temperature, and the precipitate that formed was filtered off. The mother liquid was acidified by 0.1 M aq HCl topH 5. The precipitated product was filtered and dried atroom temperature in vacuo. 2-Oxo-2-(1H-pyrazol-4-yl)acetic acid (13a). Yield10.6 g (76%). Colorless solid. Mp >280C. 1H NMR spectrum (DMSO-d6), delta, ppm (J, Hz): 8.02 (1H, s, H-5);8.17 (1H, s, H-3). 13C NMR spectrum (DMSO-d6), delta, ppm:119.8 (C-4); 136.5 (C-3); 137.6 (C-5); 164.3 (CO); 185.8(COOH). Mass spectrum (APCI), m/z: 139 [M-H]-. Found, %:C 42.72; H 2.82; N 20.14. C5H4N2O3. Calculated, %:C 42.87; H 2.88; N 20.00.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 180207-57-2.

Electric Literature of 180207-57-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 180207-57-2 as follows.

A mixture of thionyl chloride (6.318 g, 53.55 mmol) and 2-(1H-pyrazol-4-yl)ethan-1-ol (2.0 g, 17.85 mmol) was heated to 70C for 15 minutes. The reaction mixture was concentrated under reduced pressure, the residue was triturated with ethanol/diethyl ether to the title compound (2.3 g, 98%) as an off-white solid. (0690) LC-MS (method 9): f = 1.61 min; m/z = 131.06 (M+H-).

According to the analysis of related databases, 180207-57-2, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 180207-57-2

To a solution of 2-chloro-N-(2,4-dimethoxybenzyl)-5-nitrobenzenesulfonamide (661 mg,1.71 mmol) in acetonitrile (13 mL) were added 2-(1H-pyrazol-4-yl)ethanol (383 mg,3.42 mmol, CAS-RN 180207-57-2) and powdered potassium carbonate (944 mg,6.83 mmol), and the mixture was irradiated for 2h at 140C in the microwave. The reactionmixture was diluted with water and extracted with ethyl acetate. The combined organicphases were washed with brine and dried using a Whatman filter. Concentration underreduced pressure led to the title compound that was purified by flash chromatography (285 mg, 34% yield, 95% purity).LC-MS (Method B): Rt = 1.08 mm; MS (ESIpos): mlz = 463 (M+H)1HNMR (400MHz, DMSO-d6) oe [ppm]: 2.66 (t, 2H), 3.42 (s, 3H), 3.60 (s, 3H), 3.62 (td,2H), 4.17 (d, 2H), 4.75 (t, 1H), 6.11 (d, 1H), 6.26 (dd, 1H), 7.09 (d, 1H), 7.78 (d, 1H), 7.85 (s, 1H), 8.15 (s, 1H), 8.19 (d, 1H), 8.28 (t, 1H), 8.40 (dd, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 180207-57-2.