Category: 1190380-49-4

Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.

General procedure: General Procedure 35To the appropriate 1H-pyrrole-2-carboxylic acid (1 mol equiv.) in DCM (10 mL/mmol of carboxylic acid) were added triethylamine (2.5 mol equiv.), 2-chloro-1-methylpyridinium iodide (1.1 mol equiv.) and the appropriate amine (1.25 mol equiv.). The resulting solution was stirred at 42 C for 24 h. Upon completion, the solvent was removed in vacuo. The crude residue was dissolved in EtOAc (30 mL), washed with saturated aq. NaHCO3 (20 mL) and extracted with EtOAc (3 x 20 mL). The combined organic extracts were washed with brine (30 mL), dried over MgSO4 and concentrated in vacuo. The crude product was purified by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; REUILLON, Tristan; MILLER, Duncan; MYERS, Stephanie; MOLYNEUX, Lauren; CANO, Celine; HARDCASTLE, Ian; RIGOREAU, Laurent; GOLDING, Bernard; NOBLE, Martin; (246 pag.)WO2016/42341; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 1190380-49-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows.

Compound 11.4 (70 mg, 0.20 mmol, 1.00 eq.) and 1-(oxan-4-yl)-1H-pyrazol-4-amine (52 mg, 0.31 mmol, 1.50 eq.) were dissolved in HCl in dioxane (0.2 mL, 4N) and n- BuOH (2 mL). The reaction was stirred for 6 h at 110 C. The solids were collected by filtration and dissolved in H20. The pH value of the solution was adjusted to 10 with Na2CC”3. Precipitated solids were collected by filtration to provide 45.3 mg (47%) of compound I-17 as an off-white solid. LC-MS (ESI, w/z):[M+H+]+= 483; 1H NMR (300 MHz, DMSO-d6): delta 8.93 (s, 1H), 7.98 (s ,1H) , 7.50 (s, 1H), 6.85 (s, 1H), 4.44 (m, 4H) , 4.12 (m, 1H), 3.96 (m, 2H), 3.56 (t, 4H), 3.48 (m, 2H), 2.50 (m, 4H), 2.25 (m, 1H), 1.91-2.07 (m, H), 1.28-1.60 (m, 4H).

The chemical industry reduces the impact on the environment during synthesis 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; BOYCE, Sarah; (135 pag.)WO2017/4133; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1190380-49-4, category: pyrazoles-derivatives

Into a 100-mL round-bottom flask was placed compound 14.2 (85 mg, 0.24 mmol, 1.00 eq.), n-BuOH (15 mL), 1-(oxan-4-yl)-1H-pyrazol-4-amine (61 mg, 0.36 mmol, 1.50 eq.), and hydrogen chloride in dioxane (1 mL, 4N). The resulting solution was stirred for 30 h at 110 C in an oil bath and then concentrated in vacuo. The resulting solution was diluted with H20. The pH value of the solution was adjusted to 10 with sodium carbonate and the solids were collected by filtration. The solid was dried under infrared light. This resulted in 71.4 mg (61%) of I-22 as an off-white solid. LC-MS (ESI, m/z): [M+H+]= 481.2; 1H NMR: (4d-MeOD, ppm): 7.881 (1H, s), 7.594 (1H, s), 7.055-7.065QH, m), 6.053-6.063 (1H, m), 4.310-4.411(1H, m), 4.048-4.310 (3H, m), 3.974 (3H, s), 3.623-3.743 (4H, m), 3.537-3.623 (2H, m), 2.634-2.644 (4H, m), 2.275-2.409 (3H, m), 2.019-2.167 (6H, m), 1.335-1.563 (4H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; BOYCE, Sarah; (135 pag.)WO2017/4133; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 1190380-49-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows.

1-(Oxan-4-yl)-1 H-pyrazol-4-amine (51 mg, 0.303mmol) was added to a solution of A7 (59mg, 0.151 mmol) in dioxane (2mL). The reaction mixture was stirred at 70C for 17h. The mixture was diluted with EtOAc (30ml_) and was washed with sat aq NaHC03 (2 x 10ml_) and brine (2 x 10ml_) before drying over MgS04 and cone, in vacuo. The crude reaction mixture was purified by preparative TLC on silica, eluting with 5% MeOH/10% iPr20/CH2CI2 to give the title compound as a white solid (19mg, 26%). 1H NMR (500MHz, CDCI3 + 1 drop DMSO-d6) 8.52-8.50 (1 H, m), 8.31-8.11 (1 H, m), 7.97-7.92 (1 H, m), 7.62 (1 H, s), 7.27-7.20 (4H, m), 5.83-5.65 (2H, m), 4.40-4-27 (1 H, m), 4.18-4.08 (2H, m), 3.76-3.62 (2H, m), 3.61-3.48 (2H, m), 3.18-3.04 (3H, m), 2.15-2.03 (5H, m). LCMS (Method 1 ) Rt 1 .883min. ESIMS m/z [M+H]+ 475.2.

The chemical industry reduces the impact on the environment during synthesis 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BIONOMICS LIMITED; HARVEY, Andrew John; RIPPER, Justin Anthony; HUFF, Belinda Cheryl; PAUL, Dharam; WO2015/123722; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine

General procedure: [00495] A mixture of 2-chloro-N-(( 1 r,4r)-4-morpholinocyclohexyl)-5 -phenyl-7-tosyl-7H-pyrrolo [2,3 – djpyrimidin-4-amine (79 mg, 0.14 mmol, 1.0 eq), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine 9 (49mg, 0.30 mmol, 2.3 eq), and trifluoroacetic acid (0.20 mL, 2.6 mmol, 19 eq) in 2.0 mL of isopropanol was heated at 120 C in a capped vial for 4 hr. The reaction mixture was cooled to room temperature and purified on reverse phase HPLC giving N4-(( 1 r,4r)-4-morpholinocyclohexyl)-5 -phenyl-N2-( 1 -(tetrahydro-2H-pyran- 4-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-djpyrimidine-2,4-diamine as a white powder after lyophilization (1.9 mg, 2% yield). LC-MS: M+H=543.3. Also isolated 30 mg of beige solid as N4-((lr,4r)-4- morpholinocyclohexyl)-5 -phenyl-N2-(1 -(tetrahydro-2H-pyran-4-yl)- 1H-pyrazol-4-yl)-7-tosyl-7H- pyrrolo [2,3 -djpyrimidine-2,4-diamine (31% yield).

According to the analysis of related databases, 1190380-49-4, the application of this compound in the production field has become more and more popular.

Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.

Into a 50-mL round-bottom flask, was placed 23.2 (100 mg, 0.27 mmol, 1.00 eq.), n-BuOH (10 mL), 1-(oxan-4-yl)-1H-pyrazol-4-amine (90 mg, 0.54 mmol, 2.01 eq.), and hydrogen chloride in dioxane (1 mL, 4 M). The resulting solution was stirred for 30 h at 110 C in an oil bath. The resulting mixture was concentrated in vacuo. The resulting solution was diluted with H20. The pH value of the solution was adjusted to 10 with sodium carbonate. The solids were collected by filtration. The crude product was purified by Flash- Prep-HPLC with the following conditions (IntelFlash-1): Column, C18; mobile phase, ACN_Water=0: l increasing to ACN_Water=l :0 within 15 min; Detector, UV 254 nm. This resulted in 15.6 mg (12%) of I-24 as a brown solid. LC-MS: (ESI, m/z): [M+H+]= 505.3. 1H NMR: {4d-MeOD, ppm) 7.889 (1H, s), 7.590 (1H, s), 7.055-7.065 (1H, m), 6.050-6.060 (1H, m), 4.302-4.408 (1H, m), 4.054-4.171 (3H, m), 3.941-3.974 (3H, s), 3.528-3.615 (2H, m), 2.722-2.755 (4H, m), 2.539-2.607 (1H, m), 2.279-2.321 (2H, m), 2.047-2.174 (6H, m), 1.300- 1.700 (8H, m), 0.350 (4H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.

Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 100 ml flask were added methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate (309 mg, 1.4 mmol), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-amine (234 mg, 1.4 mmol), 10 ml of acetonitrile and DIPEA (0.54 g, 4.18 mmol). The reaction mixture was stirred at 40 C. for 1 h, acetonitrile was evaporated under reduced pressure and then 30 ml of EtOAc was added. The mixture was washed with 60 ml of water and 30 ml of brine. The organic phase was dired and concentrated to give 405 mg of intermediate 7a as a grey solid. MS m/z (ESI): 352.1[M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, and friends who are interested can also refer to it.

Synthetic Route of 1190380-49-4,Some common heterocyclic compound, 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, molecular formula is C8H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a microwave tube was added N-(2-bromopyridin-4-yl)-2,6-dichlorobenzamide (0.083 g, 0.24 mmol), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine (0.048 g, 0.29 mmol), Pd2(dba)3 (0.022 g, 0.024 mmol), XantPhos (0.028 g, 0.048 mmol), Cs2CO3 (0.16 g, 0.48 mmol) and dioxane (2 mL). The mixture was degassed with N2 for 10 min. The resulting mixture was irradiated in a microwave reactor at 140 C. for 3 hours and then cooled to room temperature. The mixture was filtered through Celite and concentrated under reduced pressure. The residue was dissolved in DMF and purified by prep-HPLC (Gilson GX 281, Shim-pack PRC-ODS 250 mm¡Á20 mm¡Á2, gradient: CH3CN/10 mm/L NH4HCO3, 17 min) to give the desired product as a white solid (26 mg, yield: 25%). 1H NMR (500 MHz, d6-DMSO): delta 10.87 (s, 1H), 8.83 (s, 1H), 8.02 (d, J=5.5 Hz, 1H), 7.97 (s, 1H), 7.60 (d, J=3.0 Hz, 2H), 7.53 (t, J=3 Hz, 1H), 7.43 (s, 1H), 7.24 (s, 1H), 6.77 (d, J=5.0 Hz, 1H), 4.34 (m, 1H), 3.98-3.94 (m, 2H), 3.49-3.45 (m, 2H), 1.95-1.91 (m, 4H). LCMS (ESI) m/z: 432.0 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, its application will become more common.

Some common heterocyclic compound, 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, molecular formula is C8H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1190380-49-4

To a 20 mL vial containing 5-chloro-2-ethyl-N-[trans-4-(morpholin-4-yl)cyclohexyl]-[1,3]thiazolo[5,4-d]pyrimidin-7-amine (600 mg, 1.57 mmol, 1.00 equiv) and 1-(oxan-4-yl)-1H- pyrazol-4-amine (480 mg, 2.87 mmol, 1.83 equiv) in isopropanol (15 mL) was added 0.1 mL of HC1 (4m in dioxane) at room temperature. The final reaction mixture was irradiated in a microwave reactor for 3 h at 140C. After cooling, the solids were collected by filtration purified by flash column chromatography to yield 636.7 mg (79%) of 2-ethyl-5-N-[1-(oxan-4-yl)-1H- pyrazol-4-yl] -7-N-[trans-4-(morpholin-4-yl)cyclohexyl]- [1,3 ]thiazolo [5 ,4-d]pyrimidine-5 ,7-diamine as a light yellow solid. ?H-NMR (300 MHz, DMSO) 5 9.04 (s, 1H), 7.91 (s, 1H), 7.46 (s, 1H), 7.43 (br s, 1H), 4.42-4.25 (m, 1H), 4.12-3.85 (m, 3H), 3.57 (s, 4H), 3.43 (td, 2H), 2.97 (q, 2H), 2.49 (s, 4H), 2.30-2.15 (m, 1H), 2.08-1.82 (m, 8H), 1.58-1.40 (m, 2H), 1.39-1.22 (m, 5H). LCMS (ES, m/z): 513 (M+Hj.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1190380-49-4, its application will become more common.