Category: 16617-46-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., 16617-46-2

Following the procedure described in Example 1 wherein METHANESULFONIC acid was used as the catalyst instead of hydrochloric acid, 83percent of the product was obtained after thorough washing with water and drying with m. p. 183-186 ¡ãC.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

16617-46-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below.

The compound 5-amino-1H-pyrazole-4-carbonitrile 7a (20 g, 185 mmol) It was dissolved in N, N-dimethylformamide (200 mL), cooled to 0 C, and N-bromosuccinimide (34 g, 190 mmol) was added in portions, and the mixture was warmed to room temperature and stirred for 2 hours.The reaction solution was poured into a sodium sulfite solution, and extracted with ethyl acetate (200 mL ¡Á 3). The organic phases were combined and dried over anhydrous sodium sulfate, filtered to remove the drying agent, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (dichloro Methane / methanol = 20/1) to give the target product 5-amino-3-bromo-1H-pyrazole-4-carbonitrile 7b (32 g, yellow solid), yield: 93%.

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