Category: 16617-46-2

Reference of 16617-46-2,Some common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of compound II (2.6 g, 10 mmol) and nitrile III (1.1 g, 10.2 mmol) in ethanol (30 ml) was dissolved at lab temperature and then, a saturated solution of hydrogen chloride in ethanol (1 ml) was added. The resulting mixture was boiled for 2 hours using a reflux condenser and, then, cooled down to 5 to 10 °C and the precipitated crystals were sucked off, washed with water and air dried. 2.6 g of crude product (85percent), m. p. 184-188 °C were obtained. After crystallization, 2.4 g (79percent) of crystals were obtained with m. p. 187-188 °C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-1H-pyrazole-4-carbonitrile, its application will become more common.

Reference:
Patent; ZENTIVA, A.S.; WO2004/37824; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ethyl 3-(3,4-dichlorophenyl)-3-oxopropanoate (1.2 g, 4.60 mmol, 1.20 equiv), 5-amino-lH-pyrazole-4-carbonitrile (400 mg, 3.70 mmol, 1.00 equiv), butan-l-ol (1 mL), and TsOH (10 mg, 0.06 mmol, 0.05 equiv) was stirred for 1 h at 130°C. The reaction progress was monitored by LCMS. The solids were collected by filtration. The solid was washed with 3×1 mL of methanol. This resulted in 0.8 g (71percent) of 5-(3,4-dichlorophenyl)-7-oxo-4H,7H-pyrazolo[l,5-a]pyrimidine-3- carbonitrile as a white solid. *H NMR (300 MHz, DMSO): delta 8.44 (s, 1H), 8.17 (s, 1H), 7.85 (s, 1H), 6.37 (s, 1H)

Statistics shows that 3-Amino-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 16617-46-2.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C4H4N4

Following the procedure described in Example 1 wherein propanol was used as the solvent instead of ethanol, 86percent of the product was obtained with m. p. 185-188 ¡ãC.

The synthetic route of 16617-46-2 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Amino-1H-pyrazole-4-carbonitrile

Commercially available 5-amino-lH-pyrazole-4-carbonitrile (2.0 g, 18.5 mmol) was mixed with formamide (10 mL) and heated to 180¡ãC overnight under nitrogen. The solution was cooled to rt, 60 mL of water was added, and the resulting precipitate was collected by vacuum filtration to yield C (2.367 g, 95percent). 3/4 NMR (DMSO-d6, 300 MHz) delta 8.13 (s, 1H), 8.06 (s, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.

Related Products of 16617-46-2,Some common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 30; (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-l-yl)pyrazolori,5-alpyrimidine-3-carboxamide; Step A: Preparation of 5-hydroxypyrazolo[l,5-alpyrimidine-3-carbonitrile.; To a mixture of 5-amino-lH-pyrazole-4-carbonitrile (2.70 g, 25.0 mmol) and CS2CO3 (16.3 g, 50.0 mmol) in dry DMF (70 mL) was added ethyl 3-ethoxyacrylate (5.41 g, 37.5 mmol) and the mixture was heated at 100 0C for 4 hours. The mixture was cooled to ambient temperature and the resultant slurry was poured into deionized H2O (150 mL). The resulting aqueous solution was cooled on an ice bath and concentrated HCl was added slowly with mixing to pH = 3.5. The resulting precipitate was collected, washed with H2O followed by Et2O. The solid was dried in vacuum to afford the product as a light beige powder (3.87 g, 97percent). MS (apci) m/z = 159.0 (M-I).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-1H-pyrazole-4-carbonitrile, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H4N4

Following the procedure described in Example 1 wherein 2-propanol was used as the solvent instead OF ETHANOL, 91 percent OF THE product was obtained with m. p. 184-187 ¡ãC.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.

Related Products of 16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. A solution of 5-amino-1H-pyrazole-4-carbonitrile (10 g, 92.51 mmol, 1.00 equiv) in formamide (80 mL) was stirred under nitrogen at 165 ¡ãC for 5 h. The reaction mixture was cooled to room temperature and the solid was collected by filtration. The filter cake was washed first with 20 mL of water then 20 mL of methanol and dried to yield 9.5 g (76percent) of 1H-pyrazolo[3,4-d]pyrimidin-4-amine as a white solid.

Statistics shows that 3-Amino-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 16617-46-2.

Application of 16617-46-2, A common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, molecular formula is C4H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-amino-lH-pyrazole-4-carbonitrile (500 mg, 4.63 mmol) in n- BuOH (1 mL) was added ethyl 3-(l -methyl- lH-indazol-5-yl)-3-oxopropanoate (1.7 g, 6.90 mmol), p-TsOH (40 mg, 0.23 mmol) with stirring for 1 h at 130¡ãC. The product was collected by filtration and washed with methanol (3 x 5 ml) to afford 5- (l-methyl-lH-indazol-5-yl)-7-oxo-4H,7H-pyrazolo[l,5-a]pyrimidine-3-carbonitrile as a light yellow solid (1 g, 74percent). LCMS (ES, m/z): [M+H]+ 291.0; *H NMR (300 MHz, DMSO) delta 8.40 (s, 1H), 8.25 (s, 1H), 8.20 (s, 1H), 8.01 (d, / = 9.00 Hz, 1H), 7.76 (d, / = 9.00 Hz, 1H), 6.28 (s, 1H), 4.12 (s, 3H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

16617-46-2, Adding a certain compound to certain chemical reactions, such as: 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16617-46-2.

A solution of diethyl isopropylmalonate (2.1?mL, 10?mmol), 3-amino-4-pyrazolecarbonitrile (1.1?g, 10?mmol), and NaOEt (20% in EtOH, 10?mL) in EtOH (5?mL) was heated by MW at 160?C for 0.5?h. MeOH was added to the reaction mixture and the reaction mixture was acidified with 4?N HCl in AcOEt to adjust the pH to 1. The precipitate was collected by filtration and washed with Et2O to give 28 (2.18?g, quant.): 1H NMR (DMSO-d6, 300?MHz, delta; ppm), 8.21 (1H, s), 3.21 (1H, m), 1.21 (6H, d, J?=?6.6?Hz).

According to the analysis of related databases, 16617-46-2, the application of this compound in the production field has become more and more popular.

16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

– Synthesis of Intermediate Compound (4) – 4.5 parts of Compound (3) was added to 45 parts of phosphoric acid and dissolved by heating at 38¡ãC. The resulting solution was cooled on ice and kept at -3 to 0¡ãC, and 3.0 parts of sodium nitrite were added thereto and stirred for 1 hour to give a diazonium salt solution. Separately, 10 parts of Compound (2) synthesized above were dissolved in 30 parts of methanol to prepare a solution of Compound (2). The above diazonium salt solution was added thereto at 8¡ãC or less. Simultaneously with the completion of the addition, the ice bath was removed, and the mixture was stirred for 2 hours. The reaction solution was added to 300 parts of water at 10¡ãC under stirring and stirred for additional 1 hour. Precipitated crystals were separated by filtration and sufficiently washed with water. The crystals were dried to give 12.5 parts of Intermediate Compound (4). The yield was 83.4percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.