Category: 16617-46-2

Synthetic Route of 16617-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of aldehyde (2 mmol), 3-aminopyrazole (1 mmol), and p-toluenesulfonic acid catalyst (20 mol percent) in MeCN (5 mL) was magnetically stirred for 24 h in room temperature. Next TsCH2NC (1 mmol) was added and the reaction mixture was stirred for 24 h in room temperature. After completion of the reaction, which was followed by TLC EtOAc/petroleum ether 4:1, the reaction mixture was filtered, and the precipitate washed with methanol. Finally pure solid product was obtained by column chromatography.

The synthetic route of 3-Amino-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rahmati, Abbas; Eskandari-Vashareh, Miranda; Alizadeh-Kouzehrash, Meysam; Tetrahedron; vol. 69; 21; (2013); p. 4199 – 4204;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., name: 3-Amino-1H-pyrazole-4-carbonitrile

To a solution of 3-amino-4-cyanopyrazole (100 g, 0.9 mol) in DMF (1 L) is added NBS (197.5 g, 1.1 mol) and mixture is stirred for 10 h at ambient temperature. The mixture is concentrated in vacuo then dissolved in EtOAc and washed with brine (8×). The organics are collected and concentrated in vacuo to afford I-70 (50 g, 29%) m/z 187.0 [M+].

The synthetic route of 16617-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BENTZIEN, Joerg Martin; BERRY, Angela Kay; BOSANAC, Todd; BURKE, Michael Jason; DISALVO, Darren Todd; HORAN, Joshua Courtney; LIANG, Shuang; MAO, Can; MAO, Wang; SHEN, Yue; SOLEYMANZADEH, Fariba; ZINDELL, Renee M.; US2014/45813; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 16617-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Following the procedure described in Example 11 wherein dioxane was used as the solvent instead of tetrahydrofuran and hexane was added instead of water after the reaction was completed, 86percent of the product was obtained with m. p. 183-187 °C Example 13 Following the procedure described in Example 1 wherein hydrobromic acid was used as the catalyst instead of hydrochloric acid, 81percent of the product was obtained with m. p. 184- 188 °C.

The synthetic route of 3-Amino-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZENTIVA, A.S.; WO2004/37824; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 16617-46-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of compound SI (5.0 g, 46.30 mmol) and 2-bromo-l,l- diethoxyethane (10.0 g, 50.90 mmol) in DMF (20 mL) was added K2CO3 (12.78 g, 92.60 mmol) in one portion. The reaction mixture was stirred at 80 °C overnight. After cooling to room temperature, the mixture was poured into ice water and extracted with ethyl acetate (250 mL). The organic layer was washed with brine, dried over anhydrous Na2S04, filtered and then concentrated. The residue was purified by column chromatography on silica gel (petroleum ethenethyl acetate = 100: 1 to 5: 1) to afford compound S2 (9 g, yield 90percent) as a yellow oil.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-1H-pyrazole-4-carbonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 16617-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Following the procedure described in Example 1 wherein 2-methoxyethanol was used as the solvent instead of ethanol, 76percent of the product was obtained with m. p. 184-187 °C.

The synthetic route of 3-Amino-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZENTIVA, A.S.; WO2004/37824; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 16617-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Following the procedure described in Example 1 wherein 2-methoxyethanol was used as the solvent instead of ethanol, 76percent of the product was obtained with m. p. 184-187 °C.

The synthetic route of 3-Amino-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZENTIVA, A.S.; WO2004/37824; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 16617-46-2,Some common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-1H-pyrazole-4-carbonitrile (1) (5 g, 0.046 mol) was added to cooled concentrated sulphuric acid (10 ml) with stirring sothat the temperature did not rise above 20 °C. The addition took about one-half hour and solution was stirred at room temperaturefor 4 h. The acid solution was then poured with stirring into ice and the solution was kept overnight in the refrigerator. The solid was then filtered and washed with water to free of excess sulphuric acid to afford the desired product 5-amino-1H-pyrazole-4-carboxylic acid amide (2) as white solid; (5.19 g, 89percent); mp 220-222 °C (Lit.mp 222-225 °C) [33].

The synthetic route of 16617-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Singla, Prinka; Luxami, Vijay; Singh, Raja; Tandon, Vibha; Paul, Kamaldeep; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 24 – 35;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. A solution of 5-amino-1H-pyrazole-4-carbonitrile (10 g, 92.51 mmol, 1.00 equiv) in formamide (80 mL) was stirred under nitrogen at 165° C. for 5 h. The reaction mixture was cooled to room temperature and the solid was collected by filtration. The filter cake was washed first with 20 mL of water then 20 mL of methanol and dried to yield 9.5 g (76percent) of 1H-pyrazolo[3,4-d]pyrimidin-4-amine as a white solid.

Statistics shows that 3-Amino-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 16617-46-2.

Reference:
Patent; Taunton, JR., John William; Brameld, Kenneth Albert; Goldstein, David Michael; Mcfarland, Jesse; Krishnan, Shyam; Choy, Jonathan; US2014/323464; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 16617-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A solution of aldehyde (2 mmol), 3-aminopyrazole (1 mmol), and p-toluenesulfonic acid catalyst (20 mol percent) in MeCN (5 mL) was magnetically stirred for 24 h in room temperature. Next TsCH2NC (1 mmol) was added and the reaction mixture was stirred for 24 h in room temperature. After completion of the reaction, which was followed by TLC EtOAc/petroleum ether 4:1, the reaction mixture was filtered, and the precipitate washed with methanol. Finally pure solid product was obtained by column chromatography.

The synthetic route of 3-Amino-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rahmati, Abbas; Eskandari-Vashareh, Miranda; Alizadeh-Kouzehrash, Meysam; Tetrahedron; vol. 69; 21; (2013); p. 4199 – 4204;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Amino-1H-pyrazole-4-carbonitrile

To a solution of 3-amino-4-cyanopyrazole (100 g, 0.9 mol) in DMF (1 L) is added NBS (197.5 g, 1.1 mol) and mixture is stirred for 10 h at ambient temperature. The mixture is concentrated in vacuo then dissolved in EtOAc and washed with brine (8×). The organics are collected and concentrated in vacuo to afford I-70 (50 g, 29%) m/z 187.0 [M+].

The synthetic route of 16617-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BENTZIEN, Joerg Martin; BERRY, Angela Kay; BOSANAC, Todd; BURKE, Michael Jason; DISALVO, Darren Todd; HORAN, Joshua Courtney; LIANG, Shuang; MAO, Can; MAO, Wang; SHEN, Yue; SOLEYMANZADEH, Fariba; ZINDELL, Renee M.; US2014/45813; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics