Category: 330792-70-6

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is , belongs to pyrazoles-derivatives compound. In a document, author is Outahar, Fatima, SDS of cas: 330792-70-6.

Synthesis of novel spiro-pyrazole and spiro-isoxazoline derivatives of 9 alpha- and 9 beta-hydroxyparthenolide

A series of novel spiropyrazoles and spiroisoxazolines was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9 alpha- and 9 beta-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. The structures and stereochemistry of the cycloadducts were fully established by spectroscopic methods including X-ray diffraction data. (C) 2020 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 330792-70-6, SDS of cas: 330792-70-6.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, SMILES is N#CC1=C(N)NN=C1C2=CC=C(OC3=CC=CC=C3)C=C2, belongs to pyrazoles-derivatives compound. In a document, author is Goodwin, Jack W., introduce the new discover, Computed Properties of C16H12N4O.

Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline

In this work, we report the coordination chemistry of a rigid heterotopic ligand 1H-pyrazolo[4,3-h]quinoline HL1 in copper(II) and zinc(II) complexes and examine both the structural properties and solution-phase behavior of these species. On reaction with zinc(II) nitrate in acetonitrile, a mononuclear complex [Zn(HL1)(2)(OH2)(2)](NO3)(2) 1 is generated, where a size mismatch between the metal ion and the binding pocket leads to an anomalously long Zn-N bond to the pyrazole nitrogen. This is consistent with solution-state absorption and fluorescence measurements which indicate a relatively low stability constant log beta of 9.1(3) in acetonitrile. The reaction of HL1 with copper(II) nitrate in methanol gave four new crystalline phases, the major forms of which are two polymorphs of [Cu-2(mu(2)-L1)(2)(NO3)(2)(MeOH)(2)] 2 alpha and 2 beta which also constitutes the dominant solution-phase behavior of this mixture. Additionally, trace amounts of the nitric acid salt of HL1 were crystallized along with the slow formation of a tetranuclear species [Cu-4(mu(2)-L1)(6)(OH2)(2)](NO3)(2) center dot 2MeOH3 which also features anomalously long bridging distances from L1 as a result of its backbone rigidity. [GRAPHICS]

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 330792-70-6 is helpful to your research. Computed Properties of C16H12N4O.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application of 330792-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[0411] A solution of 5-amino-3-(4-phenoxyphenyl)-IH-pyrazole-4-carbonitrile (1.0 g, 3.6mmol) in H3P04 (20 mL) was heated to 120 C for 4 hr. The mixture was then poured into water(100 mL), extracted with EA (100 mL x 3). The combined organic layers were dried overNa2S04 and concentrated to give the product (850 mg, 77.5%) as yellow solid. MS (ESI, m/e)[M+It 295.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile

Under nitrogen protection,5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.0 g, 3.6 mmol),Ethyl 2-(1-benzylpiperidin-4-ylidene)acetate (1.1 g, 4.3 mmol)A mixture of K2CO3 (745 mg, 5.4 mmol) in DMF (20 mL) was heated to 80[deg.] C. and stirred for 16 hours.Then, the reaction was quenched with water (20 mL), extracted with EA (20 mL¡Á3), the organic phases were combined, dried over Na 2 SO 4 , concentrated, and purified on a tannin extract column, eluting with 30percent EA in PE.A yellow solid product was obtained (950 mg, 54.9percent).

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.

Application of 330792-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of tert-butyl 3-(tosyloxy)piperidine- 1 -carboxylate (355 mg, 1.0 mmol) and 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (276 mg, 1.0 mmol) in 5 mL of DMF is added Cs2CO3 (650 mg, 2.0 mmol). The mixture is stirred at RT for 16 hours, 75 C for 3 hours and 60C for 16 hours. The mixture is concentrated washed with brine (100 mL x 3) and dried over Na2504. The material is concentrated and purified by chromatography column on silica gel (eluted with petroleum ether/ethyl actate = 3/1) to afford 60 mg (13%) of tert-butyl 3- (5 -amino-4-cyano-3 -(4-phenoxyphenyl)- 1H-pyrazol- 1 -yl)piperidine- 1 -carboxylate as a yellow

The synthetic route of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Application of 330792-70-6,Some common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0110] Under nitrogen atmosphere, a mixture of toluene (8.0 v), AcOH (0.5 v), BG-8 (1.2 eq.) and BG-4 (66.9 Kg 1.0 eq.) was heated to 95C and stirred until the reaction was completed. The mixture was cooled, concentrated and precipitated from methanol. The mixture was centrifuged and the cake was washed with methanol. The cake was dried under vacuum. This gave 107.8 Kg of product.1H NMR (DMSO-de) delta 8.78 (d, J= 4.6 Hz, 1H), 8.15-8.07 (m, 2H), 7.51-7.41 (m, 2H), 7.34 (d, J= 4.6 Hz, 1H), 7.27-7.19 (m, 3H), 7.17-7.10 (m, 2H), 4.24-4.02 (m, 2H), 3.81-3.69 (m, 1H), 3.12-3.82 (m, 2H), 2.15-2.04 (m, 2H), 1.76-1.60 (m, 2H), 1.43 (s, 9H).

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., 330792-70-6

[0565] To a solution of 5-amino-3-(4-phenoxyphenyl)-IH-pyrazole-4-carbonitrile (276 mg, 1.0mmol) in EtOH (10 mL) was added ethyl2-formyl-3-oxopropanoate (144 mg, 1.0 mmol) andHOAc (5 drops). After stirring at RT for 16 hr, the mixture was filtered. The cake was washedwith H20 (10 mL x 2) and dried to afford 250 mg (65percent) of ethyl3-cyano-2-(4-phenoxyphenyl)pyrazolo[l,5-a]pyrimidine-6-carboxylate as a yellow solid. MS (ESI) m/e[M+ It 384.9.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

330792-70-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

[0319] A mixture of (E)-2-( 4-( dimethylamino )-2-oxobut-3-enyl)isoindoline-1 ,3-dione ( 600 mg,2.33 mmol) and 5-amino-3-(4-phenoxy phenyl)-IH-pyrazole-4-carbonitrile (642 mg, 2.33mmol) in 20 mL of HOAc was stirred and heated to 120 ¡ãC for 15 hr. The mixture wasconcentrated and suspended in 30 mL of solvent (PE/EA = 411). The mixture was filtered andthe solid was purified by pre-TLC (DCM/EA = 5011) to give 430 mg (40percent) of 7-((1,3-dioxoisoindolin-2-yl )methyl)-2-( 4-phenoxyphenyl )pyrazolo [ 1 ,5-a ]pyrimidine-3-carbonitrile as a solid. 1H NMR (400 MHz, DMSO-d6) 8 8.74 (d, J = 4.4 Hz, IH), 8.05 (d, J = 8.8 Hz, 2H),7.96-7.90 (m, IH), 7.88-7.85 (m, 2H), 7.50 (d, J = 4.4 Hz, IH), 7.46-7.37 (m, 2H), 7.21-7.09 (m,5H), 5.32 (s, 2H). MS (ESI) m/e [M+It 472.1.

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330792-70-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 330792-70-6 name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a dry 10 L three-necked flask was added Compound 1a (600 g, 2.17 mol)Compound 2a (815 g, 2.39 mol),Powdered cesium carbonate (1417 g, 4.35 mol) and N, N-methylformamide (DMF, 6 L) were added,Mechanical stirring, heating the internal temperature rose to 80 (about 1.5 hours)After 2 hours to send HPLC monitoring reaction, the reaction is complete, stop heating, cooled to room temperature,Then add 10L ethyl acetate and 15L water, stirred for 30 minutes (speed 200), allowed to stand,Liquid separation, the water phase to discard, the organic phase with 1kg anhydrous sodium sulfate and stir, filtered,The filtrate was concentrated dark reddish brown oil, the crude product was recrystallized twice with dioxane,Obtained pale yellow powdery solid 450g, yield 46.4percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, and friends who are interested can also refer to it.

330792-70-6, Adding a certain compound to certain chemical reactions, such as: 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330792-70-6.

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (28 mg, 0.1 mmol)A mixture of 2-Bromomalonaldehyde (15 mg, 0.1 mmol) in EtOH (5 mL) was stirred at room temperature for 2 hours.The mixture was then filtered to give a crude yellow solid (20 mg, 62.9percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.