Category: 175137-46-9

These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Cyclopropyl-1H-pyrazol-3-amine

A mixture of 2,4,6-trichloropyrimidine (30 g, 163 mmol), 5-cyclopropyl-1H-pyrazol-3-ylamine (20 g, 163 mmol), diisopropylethylamine (50 mL, 300 mmol) and 1-butanol (100 mL) was heated to 80 C. for 2 h. The solvents were removed on a rotary evaporator and the residue was taken up in ethyl acetate. The organic solution was washed with water and brine and dried over magnesium sulfate. The residue was concentrated on a rotary evaporator to give the desired product (40.7 g, 92%) as a light yellow solid.

The synthetic route of 5-Cyclopropyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Related Products of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The solution of 3,5-difluoro-2-nitrobenzonitrile (Method 16; 5.80 g, 31.5 mmol), 5- cyclopropyl-lH-pyrazol-3-amine (4.66 g, 37.8 mmol) and DIEA (5.5 ml, 31.5 mmol) in THF (100 ml) was stirred at 25 C for 20 hours. The solvent was removed under reduced pressure and the residue was purified by chromatography (DCM-EtOAc = 10 : 1) to give the title compound as a yellow solid (5.50 g, 61%). NMR (400 MHz) 12.43 (s, 1H), 9.70 (s, 1H), 8.22 (d, J = 12.0 Hz, 1 H), 7.51 (d, J = 5 .2 Hz, 1 H), 5 .92 (s, 1 H), 1.89 (m, 1 H), 0.95 (m, 2H), 0.71 (m, 2H). Rt 3.19 min. MS: Calcd. : 287; Found: [M+H]+ 288.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.

These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5-Cyclopropyl-1H-pyrazol-3-amine

To a mixture of 110a (2.38 g, 7.00 mmol), 5-cyclopropyl-lH-pyrazol-3-amine (905 mg, 7.35 mmol), in 1,4-dioxane (40 mL) in a 100 mL single-neck round-bottomed flask was added cesium carbonate (6.84 g, 21.0 mmol). The mixture was purged with nitrogen for 30min. Tris(dibenzylideneacetone)dipalladium(0) (641 mg, 0.700 mmol) and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (688 mg, 1.19 mmol) were then added. The flask was connected to a nitrogen-purged condenser and the mixture was refluxed for 6 h under nitrogen. The mixture was cooled to room temperature and filtered. The filter cake was suspended in ethyl acetate (30 mL) and water (10 mL) and filtered through Celite. The layers were separated. The combined organic layers were dried with anhydrous magnesium sulfate. The drying agent was removed by filtration. The filtrate was concentrated under reduced pressure. The residue was purified on silica eluted with a gradient 0 to 50% ethyl acetate in heptane to afford 6-chloro-4-(5-cyclopropyl-lH-pyrazol-3-ylamino)-2-((2- (trimethylsilyl)ethoxy)methyl)pyridazin-3(2H)-one (111a) (1.58 g, 59%).

The synthetic route of 5-Cyclopropyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Electric Literature of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a flask was added Pd(OAc)2 (22.4 mg, 0.1 mmol), (biphenyl-2- ylmethylene)bis(dimethylphosphine) (60 mg, 0.2 mmol) and sodium tert-butoxide (240 mg, 2.5 mmol). The flask was sealed and refilled with N2. To the mixture was added a solution of EPO 6-bromo-N-(4-fluorobenzyl)pyridin-2-amine (Method 19; 281 mg, 1.0 mmol) and 5- cyclopropyl-lH-pyrazol-3 -amine (123 mg, 1.0 mmol) in toluene (5 ml). The reaction mixture was heated at 110C overnight. The solvent was removed and EtOAc was added and the mixture was washed with brine and was concentrated. Semi-prep HPLC (Gilson) purification gave the title compound (6.4 mg, 2%). 1H NMR (CDCl3) delta 0.65 (m, 2H), 0.95 (m, 2H), 1.80 (m, IH), 4.43 (m, 2H), 4.91 (br s, IH), 5.60 (br s, IH), 5.80 (m, IH), 6.18 (m, IH), 6.73 (m, IH), 7.00 (m, 2H), 7.25 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.

Application of 175137-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175137-46-9 name is 5-Cyclopropyl-1H-pyrazol-3-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 172-Chloro-N-(5-cvclopropyl-lH-pyrazol-3-yl)-5-nitropyrimidin-4-amine; A mixture of 2,4-dichloro-5-nitropyrimidine (2 g) and S-cyclopropyl-lH-pyrazol-S-amine (2 g) in acetonitrile (20 mL) with diisopropylethylamine (2 mL) was stirred at room temperature for 24 hours, The resulting mixture was concentrated, and the resulting residue was separated by silica gel column (etaexane/Ethyl acetate) to afford 2.1 g desired product. MS (electrospray): 281 (M+l) for Ci0H9ClN6O2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Cyclopropyl-1H-pyrazol-3-amine, and friends who are interested can also refer to it.

Electric Literature of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of S-cyclopropyl-lH-pyrazol-S -amine (1.9g, 16.0 mmol) in CH3CN (20 ml) was added dropwise to a solution of 2,6-dichloro-5-fluoronicotinonitrile (3.0g, 16.0 mmol) and triethylamine (2.1g, 20.0 mmol) in CH3CN (80 ml) at 25 C. The resulting solution was then heated to 82 C for 18 hrs, and then cooled to 25 C, at which point the product precipitated from solution. The resulting solid was filtered, and washed with CH3CN (100 ml) to give the title compound (3.2g, 73%). MS: Calcd.: 277; Found: [M+H]+ 278.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.

Related Products of 175137-46-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

17/18D. trans-Methyl 2-(4-(5-cyclopropyl-lH-pyrazol-3-ylamino)pyrrolo[l,2-f][l,2,4]triazin-2-yl)cyclopentanecarboxylate. trans-Methyl 2-(4-oxo-3,4-dihydropyrrolo[l,2-f][l,2,4]triazin-2- yl)cyclopentanecarboxylate hydrochloride (450 mg, 1.51 mmol) was dissolved in POCl3 (10 mL, 107 mmol) and heated to 85 0C for 1.5 h, then at 100 0C for an additional 4.5 h. The reaction was cooled to rt and concentrated in vacuo, co- evaporating with toluene several times. NMP (6 mL) was added to the residue, and the reaction was heated to 80 0C before a solution of 5-cyclopropyl-lH-pyrazol-3- amine (922 mg, 7.49 mmol) dissolved in NMP (6 mL) was slowly injected. The reaction was stirred overnight at 80 0C, then cooled to rt. EtOAc (250 mL) was added, and the reaction was washed with water (2 x 150 mL) and brine (150 mL). The organic layer was dried (MgSO4), filtered, and concentrated in vacuo. The compound was purified by silica gel flash chromatography (0-40% 90: 10: 1 [CH2Cl2ZMeOHZcOnC NH4OH]ZCH2Cl2), followed by trituration with 1: 1 CH2Cl2ZHeX to give 17/18D (260 mg, 50%). 17/18D had an analytical HPLC retention time = 2.15 min (Waters XBridge 4.6 x 50 mm, 5-95% aqueous acetonitrile over 5 min containing 10 mM ammonium acetate) and a LCZMS M+ + 1 = 367.

The chemical industry reduces the impact on the environment during synthesis 5-Cyclopropyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, 175137-46-9

Example 2; N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-{[3-(methyloxy)phenyl]sulfanyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine; 2A. 2-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine; A mixture of 1B (977 mg, 5.2 mmol), 5-cyclopropyl-1H-pyrazol-3-amine (640 mg, 1 equiv), and diisopropylethylamine (1.54 mL, 1.7 equiv) in 5 mL IPA was stirred at RT overnight. The precipitate was collected by filtration to give 1.18 g 2A (83% yield). 1H NMR (CDCl3): 0.67 (m, 2H), 0.86 (m, 2H), 1.77 (m, 1H), 6.6 (br. s, 1H), 6.54 (br.s, 1H), 6.79 (br. s, 1H), 7.42 (br.s, 1H); MS: 275 (M+H)+; and RP HPLC ret. t.: 1.56 min (Phenomenex-Luna S10: 3.0¡Á50 mm column, 2 min gradient, 4 mL/min).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Cyclopropyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

175137-46-9, These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound of example 33 (4.92 mmol) was reacted with 5-cyclopropyl-1H-pyrazol-3-amine(5.91 mmol) in presence of DMF (4.92 mmol), ethanol (148 mmol), sodium iodide (4.92 mmol)and triethylamine (24.62 mmol). The reaction mixture was stirred at a temperature of 100 C for 2 days. The DMF and excess triethylamine was evaporated followed by addition of water and ethyl acetate. The organic layer was separated and concentrated for purification using column chromatography (silica gel, 0.5 % methanol dichloromethane) to obtain the title compound.Yield: 70.1 %; ?H NMR (DMSO-d6, 300 MHz): oe 12.14 (s, 1H), 9.00 (s, 1H), 6.23(s, 1H), 2.59 (bs, 2H), 2.50 (d, 1=9.9Hz, 2H), 1.90 (m, 1H), 1.73 (bs, 4H), 0.93 (d, 1=6.6Hz, 2H), 0.69 (m, 2H); MS (ES+): mlz 418.3 (M+1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 175137-46-9.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 175137-46-9

To a solution of (2J?)~2-[(2-chloro-5-nitro?yrimidin-4-yl)amino]-2-(4- fluoro?henyl)ethanol (Method 6; 300 mg, 0.96 mmol) in EtOH (4 ml) was added a solution of S-cyclopropyl-lH-pyrazol-S-amine (118 mg, 0.96 mmol) in EtOH (2 ml) and triethylamine (0.2 ml, 1.44 mmol). The reaction mixture was stirred at 45 0C for 18 hours. Solvent was removed and the residue was dissolved in EtOAc and was washed with water. The organic layer was concentrated. Flash chromatography on silica gel (EtOAc) gave the desired product as a yellowish solid (196 mg, 51%). NMR 0.64 (m, 2H), 0.92 (m, 2H), 1.83 (m, IH), 3.82 (m, 2H), 5.27 (m, 2H), 5.93 (m, IH), 7.12 (m, 2H), 7.39 (m, 2H), 8.95 (s, IH), 9.19 (s, IH), 10.54 (br s, IH), 12.11 (br s, IH).

The synthetic route of 175137-46-9 has been constantly updated, and we look forward to future research findings.