Category: 141573-95-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141573-95-7 as follows. Computed Properties of C8H10F2N2O2

Preparation Example V.13-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acidA mixture of ethyl 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylate (1.4 g, 52 mmol) and aqueous sodium hydroxide solution (10% strength, 3.1 g, 8 mmol) was stirred at 60 C. for 2 h. The reaction mixture was cooled to room temperature, and the pH was then adjusted to 1 using concentrated hydrochloric acid. The reaction mixture was cooled further to 0 C., resulting in the precipitation of a solid. The precipitated solid was filtered off, washed with cyclohexane and dried under reduced pressure. This gave 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acid as a solid (amount: 0.8 g; yield: 87%). 1H-NMR (DMSO-d6): delta=3.9 (s, 2H), 7.2 (t, 1H), 8.35 ppm (s, 1H).

According to the analysis of related databases, 141573-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF SE; US2011/40096; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 141573-95-7

In a 100 mL reaction flask, add ethyl 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate(38 mmol) represented by formula (II), and then add 10% by mass 30mL NaOH aqueous solution, heated to 60 C and stirred until the reaction solution was transparent, and then naturally cooled to room temperature. The reaction solution was adjusted to pH about 2.0 by adding acid, a large amount of solid was precipitated, filtered by suction, and the filter residue was washed with water and dried to obtain the formula 1) -methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang University of Technology; Liu Xinghai; Cai Pengpeng; Jin Tao; Tan Chengxia; Weng Jianquan; Wu Hongke; (11 pag.)CN110669007; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 141573-95-7, A common heterocyclic compound, 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C8H10F2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The aniline compound (la to Id) (leq.) and DFMMP (1 eq.), both dissolved in an inert solvent were added to a suspension of a base (1.5 eq.) in the inert solvent at 0C. The conversion of aniline to anilide was followed by GC analyses.

The synthetic route of 141573-95-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SOLVAY SA; BRAUN, Max, Josef; WO2012/55864; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

To the toluene layer was added 25% caustic soda solution159 g (0.994 mole) of the compound were added thereto, and the mixture was heated to 65 DEG C and stirred for 45 minutes. The aqueous layer was separated, and 54 g of water and 160.2 g (1.54 mole) of 35% hydrochloric acid were added to the toluene layer, followed by stirring at 85 for 15 minutes. After cooling to room temperature the resulting crystals were filtered, washed with 180 g of water and dried in vacuo at 60 & lt; RTI ID = 0.0 & gt;To obtain 155.8 g (yield 98%) of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid.

The synthetic route of Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Buheung Industries Co., Ltd.; Ahn, Kyung Wook; Kim, Jong Nam; Wang, Kyu Jung; Noh, Dong Won; Seo, Nan Young; Kim, Sin Ae; Wei, Sung Han; (10 pag.)KR2016/120009; (2016); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 141573-95-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

10 g [44.27 mmol, 98.9% GC purity] of 3′,4′,5′-trifluorobiphenyl-2-amine and 9.04 g [44.27 mmol, 99% GC purity] of ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate were dissolved in 35 g of toluene and 7.5 g of NMP. This solution was admixed, under agitation, with 8.37 g of sodium methoxide (30% by weight in methanol) added at 70 C. and 500 mbar in the course of 20 minutes. Methanol and ethanol were removed from the reaction mixture as azeotrope with toluene. On completion of the addition of sodium methoxide the reaction mixture was subsequently stirred at 500 mbar and 70 C. for 15 minutes. The vacuum was then reduced to 300 mbar for 2 hours and to 200 mbar for a further hour. The reaction was tracked via GC-MS analysis to obtain 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide having a GC-MS purity of 39%.

The synthetic route of Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Moradi, Wahed Ahmed; Lui, Norbert; Dockner, Michael; US2014/128617; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 141573-95-7, A common heterocyclic compound, 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C8H10F2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1Ethyl 5-chloro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate (III-1) 20.25 g (100 mmol) of ethyl 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylate and 40 ml of SO2Cl2 are placed under argon and the mixture is heated to 60 C. and stirred at this temperature for 8 hours. After diluting the mixture with ethyl acetate, washing with water and removing the solvent under vacuum, 21 g of the product are obtained with an HPLC purity of 94%. M.p. 37-39 C.1H NMR (CDCl3): delta=7.1 (1H, t), 4.3 (q, 2H), 3.9 (s, 3H), 1.4 (t, 3H) ppm.19F NMR (CD3CN): delta=-114.9 (2F, t) ppm.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Bayer CropScience AG; US2011/288305; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Formula: C8H10F2N2O2

ethyl 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate containing 0.2 area%, Purity 96.6 area% of ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 10.0 g (0.05 mol), toluene 94 g, water 15.2 g, 25 wt% sodium hydroxide aqueous solution 1.8 g (0.07 mol) were added to the 200ml round-bottomed flask, while stirring it was heated in an oil bath and reacted under reflux for 23 hours. After cooling to room temperature, 15 mass% hydrochloric acid 21.0 g (0.09 mol) was dropped from the dropping funnel. After dropping, after cooling for 1 hour in an ice-water bath, using a 5C filter paper, suction filtered through a Kiriyama funnel, the filtrate was washed with 2 volumes of cold water. The obtained filtrate was dried under reduced pressure at 80 C. for 4 hours and got 8.60 g of crystals. When this crystal was analyzed by HPLC, it was 3- (difluoromethyl) -1-methyl -1H- pyrazole-4-carboxylic acid : 99.2 area %, 5- (difluoromethyl) -1-methyl-1 H-pyrazole-4-carboxylic acid : 0.1 area %. The toluene layer obtained by separating the filtrate into two layers, after concentrated in an evaporator, dried under reduced pressure at 80 C for 4 hours, got 0.02 g of crystals. When this crystal analyzed by HPLC, it was 3- (difluoromethyl) -1-methyl -1H- pyrazole-4-carboxylic acid : 27.2 area %, 5- (difluoromethyl) -1-methyl-1 H-pyrazole-4- carboxylic acid: 15.0 area %.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CENTRAL GLASS COMPANY LIMITED; IMURA, HIDEAKI; TAKADA, NAOTO; (11 pag.)JP5830957; (2015); B2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 2 (5.1 g, 25 mmol) and KOH (1.68 g, 30 mmol) were added to water (50 mL). The mixture was stirred for overnight, then acidified to pH = 1 using HCl, to give 3 as a white solid that was filtered off and dried with yield 83%, m.p. 200-201 C (Ref. m.p. 204-205 C) [38] , 1H NMR (400 MHz, CDCl3), delta 3.91 (s, 3H, N-CH3), 7.19 (t, J = 54.2 Hz, 1H, -CHF2), 8.31 (s, 1H, pyrazolyl-H), 12.73 (s, 1H, -COOH).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 141573-95-7.

Reference:
Article; Liu, Xing-Hai; Zhao, Wen; Shen, Zhong-Hua; Xing, Jia-Hua; Xu, Tian-Ming; Peng, Wei-Li; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 881 – 889;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141573-95-7 as follows. COA of Formula: C8H10F2N2O2

Preparation Example V.13-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acidA mixture of ethyl 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylate (1.4 g, 52 mmol) and aqueous sodium hydroxide solution (10% strength, 3.1 g, 8 mmol) was stirred at 60 C. for 2 h. The reaction mixture was cooled to room temperature, and the pH was then adjusted to 1 using concentrated hydrochloric acid. The reaction mixture was cooled further to 0 C., resulting in the precipitation of a solid. The precipitated solid was filtered off, washed with cyclohexane and dried under reduced pressure. This gave 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acid as a solid (amount: 0.8 g; yield: 87%). 1H-NMR (DMSO-d6): delta=3.9 (s, 2H), 7.2 (t, 1H), 8.35 ppm (s, 1H).

According to the analysis of related databases, 141573-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF SE; US2011/40096; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

30.8g (0.151mol)3-Fluoroalkyl-1-methylpyrazole-4-carboxylic acid ethyl ester (DFMPA) was put into the reaction flask, 100 g of water, 6.7 g of sodium hydroxide were added, and the reaction was stirred at 70 C for 2 hours. After the reaction was completed, Add hydrochloric acid dropwise to neutralize to pH 2, cool to 10 C, filter, wash with a little cold water, and dry to obtain 3-fluoroalkyl-1-methyl-1H-pyrazole-4-carboxylic acid (DFMPA) (such as (Expression V) 25.2 g, 95% yield, 99% purity by HPLC.

According to the analysis of related databases, 141573-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suqian Kelaibo Biochemical Co., Ltd.; Wang Mingchun; Li Qingyi; (11 pag.)CN110577503; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics