Category: 31037-02-2

Related Products of 31037-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2 g of the starting material 1-methyl-5-amino-4-ethoxycarbonylpyrazole was dissolved in 30 mL of tetrahydrofuran at room temperature and stirred to dissolve. Further, 5.2 g of triphenylmethane bromide was added, and after stirring and dissolving, 1.5 g of triethylamine was further added dropwise, and after heating, the temperature was gradually raised to 40 C.The mixture was stirred and condensed for 2.5 hours, and solids were precipitated during the reaction. After the reaction was finished, the reaction solution was gradually cooled to about 0 C.After stirring for 1 hour, the reaction solution was filtered to remove the salt component.The filter cake was washed again with 5 mL of tetrahydrofuran.A solution of the corresponding intermediate compound of formula III in tetrahydrofuran is finally obtained, which is ready for use.

The synthetic route of Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

31037-02-2, These common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of ethyl 5- Fbis(tert-butoxycarbonyl)aminol-l -methyl- lH-pyrazole-4-carboxylateEthyl S-amino-l-methyl-lH-pyrazole^-carboxylate (4.7 g, 27.78) in dichloromethane (100 mL) was stirred under nitrogen in a 500 mL flask as di-tert-butyl dicarbonate (7.88 g, 36.11 mmol) was added followed by N,N-dimethylpyridin-4-amine (339 mg, 2.78 mmol). The solution was stirred for 16 h. An additonal 5 g of di-tert-butyl dicarbonate was added and the solution was stirred for an additional 2 h. Very little starting material remained at this point and the solvents were evaporated to give a residue that was purified using silica gel. Products were eluted with a gradient from 0-80 % ethyl acetate in hexane to yield 8.1 g (79%) of the title pure material.1H NMR (300 MHz, CD2C12-4) ? 7.85 (s, IH), 4.25 (q, 2H), 2.68 (s, 3H), 1.40 (s, 18H), 1.30 (t, 3H); ES-MS m/z 370.0 [M+H]+, LCMS RT (min) 3.17.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 31037-02-2.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31037-02-2 as follows. 31037-02-2

To a stirred solution of step 2 intermediate (4.8 g, 28.37 mmol) in ethanol (28 mL), aqueous solution of potassium hydroxide (2.0 M, 28 mL, 42.555 mmol) was added and the reaction mixture was refluxed for overnight. The reaction mixture was cooled to RT, concentrated under reduced pressure. The residue was stirred in 1.0 N citric acid (80 mL). The solid precipitated was filtered and dried to yield 3.59 g of the titled product. lU NMR (300 MHz DMSO- 6): delta 3.51 (s, 3H), 6.13 (br s, 2H), 7.38 (s, 1H), 11.74 (s, 1H).

According to the analysis of related databases, 31037-02-2, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31037-02-2 as follows. 31037-02-2

The ligand, L (0.169 g; 1 mmol), was dissolved in hot MeOH (5 cm3), and CuCl2¡¤2H2O (0.085 g; 0.5 mmol) was added. Afew hours later, the brown microcrystals were filtered andwashed with MeOH and Et2O.Yield: 0.143 g (61%). Calcd. (Found) for CuC14H22N6Cl2: C, 35.56; H, 4.65; N, 17.78; (C,35.42; H, 4.64; N, 17.75). IR bands [ v/cm-1]: 3489, 3440,3347, 1682, 1633, 1557, 1460, 1218, 773. Molar conductivity,LambdaM (S cm2 mol-1): 24 (DMF).

According to the analysis of related databases, 31037-02-2, the application of this compound in the production field has become more and more popular.

31037-02-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below.

Step 1. Synthesis of ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Copper(II) bromide (99%, 20.0 g, 88.6 mmol) and tert-butyl nitrite (90%, 14.1 mL, 107 mmol) were combined in acetonitrile (65 mL) and heated to 65 C. Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (10.0 g, 59.1 mmol) was slowly added portion-wise {Caution: gas evolution!} and the reaction was maintained at 65 C. for 24 hours. The mixture was cooled to room temperature, poured into aqueous hydrochloric acid (3 N, 600 mL), diluted with ethyl acetate (300 mL) and stirred for 10 minutes. The aqueous layer was extracted with ethyl acetate (150 mL), and the combined organic layers were dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified via silica gel chromatography (Gradient: 5% to 100% ethyl acetate in heptane, with a 5-minute hold at 32%), affording the product as a pale yellow solid. Yield: 9.10 g, 39.0 mmol, 66%. LCMS m/z 233.3 (M+1). 1H NMR (500 MHz, CDCl3) delta 1.36 (t, J=7.1 Hz, 3H), 3.92 (s, 3H), 4.32 (q, J=7.1 Hz, 2H), 7.93 (s, 1H).

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31037-02-2, The chemical industry reduces the impact on the environment during synthesis 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

The ligand, L (0.169 g; 1 mmol), was dissolved in hot MeOH (5 cm3), and Cu(NO3)2¡¤3H2O (0.12 g; 0.5 mmol) was added. Three days later, brown plate-like microcrystals were filtered and washed with MeOH and Et2O. Yield: 0.159 g (60%). Calcd. (Found) for CuC14H22N8O10: C, 31.97; H, 4.18; N,21.30. (C, 31.76; H, 4.29; N, 21.13). IR bands [ v/cm-1]:3490, 3441, 3346, 1682, 1633, 1460, 1384, 1220, 1126, 771. Molar conductivity, LambdaM (S cm2 mol-1): 131 (DMF).

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

A common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 31037-02-2.

To a solution of tBuONO (2.95 mL, 2.46 mmol) in acetonitrile(ACN) was added CuCl (1.76 g, 1.77 mmol), and then added 14 (2.5 g, 1.48 mmol) to the mixture in portions. The reaction was stirred at r.t. for 2 h, and then heated at 60C for 1 h.After completion as TLC monitored, the reaction mixture was cooled to r.t. and diluted with 2 N aq. HCl, then extracted with DCM (3¡Á). The combined phases were washed withbrine, dried over MgSO4, filtered, concentrated and purifiedby flash column chromatography to give 15 (2.08 g) in 75%yield. 1H-NMR (300 MHz, CDCl3) delta: 7.90 (1H, s), 4.30 (2H, q,J=5.4 Hz), 3.86 (3H, s), 1.34 (3H, t, J=5.4 Hz).

The synthetic route of Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 31037-02-2

1-Methyl-5-(2-nitro-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester Sodium hydride (60% dispersion in oil, 7.0g, 170mmol) was added portionwise to a suspension of 5-amino-1-methyl-1H pyrazole-4-carboxylic acid ethyl ester (21.1g, 125mmol) in anhydrous THF (300ml) at 0C. The mixture was allowed to warm to room temperature and stirred for 0.75h then cooled to 0C. 1-fluoro-2-nitrobenzene (17.6g, 125mmol) was added and the resultant suspension was stirred at room temperature for 18h. EtOAc and 0.3M KHSO4 were added and separated. The aqueous layer was extracted with EtOAc and the combined organic layers were washed with brine, dried and concentrated invacuo. The residue was purified by flash chromatography on silica gel (eluant 50% hexanes/50% ethyl acetate) to yield 1-methyl-5-(2-nitro-phenylamino)-1H pyrazole-4-carboxylic acid ethyl ester (20.8g, 58%).

The synthetic route of 31037-02-2 has been constantly updated, and we look forward to future research findings.

31037-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Alternative preparation according to Process B: 540g (2.26 mmol) of 2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]aniline are initially charged in dry dichloromethane.The flask is flushed with argon, and 2.5 ml of a 2Msolution of trimethylaluminium in toluene are added dropwise.The reaction mixture is stirred at room temperature for30min, and405 mg (2.39 mmol) ofethyl5-amino-1-methyl-1H-pyrazole-4-carboxylate are then added. The mixture isstirred at room temperature overnight, and a 1 0% strengthpotassium/sodium tartrate solution is then added. The organicphase is separated off and the aqueous phase is extractedtwice with dichloromethane. The combined organic phasesare dried over sodium sulphate and the mixture is applied toRP(C-18) material. Removal of the solvents is followed bypurification by means of MPLC on an RP(C-18) columnusing water/acetonitrile. This gives 577 mg (1 00% pure, 71%of theory) of the title compound.

The synthetic route of 31037-02-2 has been constantly updated, and we look forward to future research findings.