Category: 1128-54-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Methyl-1-phenyl-1H-pyrazole

General procedure: In a typical experiment,the aryl bromide (3 mmol), heteroaromatic 1, 21 or 23 (1 mmol), KOAc(0.588 g, 6 mmol) and PdCl(C3H5)(dppb)16 (0.012 g, 0.02 mmol) were dissolvedin DMA (4 mL) under an argon atmosphere. The reaction mixture was stirred at 150 C for 72 h. Then, the solvent was evaporated and the product was purified by silica gel column chromatography.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Takfaoui, Abdelilah; Zhao, Liqin; Touzani, Rachid; Dixneuf, Pierre H.; Doucet, Henri; Tetrahedron Letters; vol. 55; 10; (2014); p. 1697 – 1701;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 1128-54-7,Some common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of Preparation 137 (2 g, 12.58 mmol) in water (50 mL) and tert-Butanol (2 mL) was heated at 70C and a solution of KMnO4 (4.97 g, 31.45 mmol) in water (120 mL) was dropwise added and mixture stirred at 70C for 12 h. Crude was filtered through Celite, concentrated and acidified with 2 N HCl. Product was extracted with ethyl acetate, organic layers were combined and washed with brine, dried over sodium sulphate, filtered and concentrated to yield the title compound as a white solid (4% yield). LRMS: m/z 189 (M+1)+ Retention time: 2.50 min (Method B) 1H NMR (400 MHz, DMSO-d6) delta ppm 6.96 (d, J=2.34 Hz, 1 H) 7.40 (t, J=7.42 Hz, 1 H) 7.55 (t, J=8.01 Hz, 2 H) 7.90 (d, J=7.82 Hz, 2 H) 8.61 (d, J=2.34 Hz, 1 H) 12.99 (br. s., 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyl-1-phenyl-1H-pyrazole, its application will become more common.

Reference:
Patent; Almirall, S.A.; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Carrascal Riera, Marta; Taboada Martinez, Lorena; Navarro Romero, Eloisa; Vidal Juan, Bernat; EP2390252; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-Methyl-1-phenyl-1H-pyrazole

General procedure: To a stirred solution of 1-phenyl-1H-pyrazole (5a) (288 mg, 2.00 mmol, 1.00 equiv.) in dryTHF (2.00 mL/mmol based on 5a), 1.64 M solution of n-BuLi in n-hexane (1.34 mL, 2.20mmol, 1.10 equiv.) was added dropwise at -78 C under an argon atmosphere. After being stirred at the same temperature for 1 h, benzoyl chloride (6a) (0.260 mL, 2.20 mmol, 1.10equiv.) was added to the mixture. After being warmed to room temperature and stirred at the same temperature for 18 h, the reaction mixture was quenched with saturated NH4Cl aq. The aqueous layer was extracted with ethyl acetate. The combined extract was washed with brine,dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel with hexane : EtOAc = 5 : 1 to give phenyl(1-phenyl-1H-pyrazol-5-yl)methanone (7a) as a white solid (429 mg, 1.73 mmol, 86%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1128-54-7, its application will become more common.

Reference:
Article; Fuse, Shinichiro; Kadonosono, Tetsuya; Kizaka-Kondoh, Shinae; Kuchimaru, Takahiro; Nakamura, Hiroyuki; Sato, Shinichi; Suzuki, Kensuke; Ueda, Hiroki; Bioorganic and medicinal chemistry; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-Methyl-1-phenyl-1H-pyrazole

General procedure: To a stirred solution of 1-phenyl-1H-pyrazole (5a) (288 mg, 2.00 mmol, 1.00 equiv.) in dryTHF (2.00 mL/mmol based on 5a), 1.64 M solution of n-BuLi in n-hexane (1.34 mL, 2.20mmol, 1.10 equiv.) was added dropwise at -78 C under an argon atmosphere. After being stirred at the same temperature for 1 h, benzoyl chloride (6a) (0.260 mL, 2.20 mmol, 1.10equiv.) was added to the mixture. After being warmed to room temperature and stirred at the same temperature for 18 h, the reaction mixture was quenched with saturated NH4Cl aq. The aqueous layer was extracted with ethyl acetate. The combined extract was washed with brine,dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel with hexane : EtOAc = 5 : 1 to give phenyl(1-phenyl-1H-pyrazol-5-yl)methanone (7a) as a white solid (429 mg, 1.73 mmol, 86%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1128-54-7, its application will become more common.

Reference:
Article; Fuse, Shinichiro; Kadonosono, Tetsuya; Kizaka-Kondoh, Shinae; Kuchimaru, Takahiro; Nakamura, Hiroyuki; Sato, Shinichi; Suzuki, Kensuke; Ueda, Hiroki; Bioorganic and medicinal chemistry; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H10N2

General procedure: A clean and oven dry sealed tube was charged with 1-phenylpyrazole (1equiv.), and styrene (2.5equiv.), to this added (Rh-Complex 0.5mol%) and Cu(OAc)2.H2O (1 equiv), of water (1mL) as a reaction medium. Thereafter, the reaction mixture was heated at 90-100C under sealed conditions for 12h. The gain in product formation was examined by periodic monitoring through TLC. Then the reaction mixture was cool to room temperature, added water (50mL) and EtOAc (75mL) and the organic layer was extracted thrice, and dried over the anhydrous Na2SO4. The crude product was obtained by evaporating the solvent under reduced pressure. Finally, the product was purified through column chromatography (EtOAc/hexane).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1128-54-7.

Reference:
Article; Satrawala, Naveen; Williams, Cody; Srivastava, Avinash K.; Sharma, Kamal N.; Smith, Gregory S.; Joshi, Raj K.; Catalysis Communications; vol. 129; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 1128-54-7,Some common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A clean and oven dry sealed tube was charged with 1-phenylpyrazole (1equiv.), and styrene (2.5equiv.), to this added (Rh-Complex 0.5mol%) and Cu(OAc)2.H2O (1 equiv), of water (1mL) as a reaction medium. Thereafter, the reaction mixture was heated at 90-100C under sealed conditions for 12h. The gain in product formation was examined by periodic monitoring through TLC. Then the reaction mixture was cool to room temperature, added water (50mL) and EtOAc (75mL) and the organic layer was extracted thrice, and dried over the anhydrous Na2SO4. The crude product was obtained by evaporating the solvent under reduced pressure. Finally, the product was purified through column chromatography (EtOAc/hexane).

The synthetic route of 1128-54-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1128-54-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1128-54-7 as follows.

General procedure: A solution of equimolar amounts of 1b [1], 1c [16],d [17],e,f[17],g and 2,5-hexanedione 2 and p-toluenesulfonic acid monohydrate(20% mol/mol than the appropriate amine) in anhydrous dioxane was refluxed for different hours (see below). At set intervals of reflux (see below), 50% of stoichiometric amounts of 2,5-hexanedione was added. Then, the solvent was removed under reduced pressure and the oily residue was purified by flash chromatography and/or crystallization as described below.

According to the analysis of related databases, 1128-54-7, the application of this compound in the production field has become more and more popular.

1128-54-7, A common heterocyclic compound, 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, molecular formula is C10H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 100 ml round bottom flask was added 3-methyl-1-phenyl -1H- pyrazole (1.58 g, 0.010 mol), was added 50 ml of carbon tetrachloride was added N- bromosuccinimide at room temperature (2.20 g, 0.012 mol), was added a catalytic amount of azobisisobutyronitrile (of AIBN), the reaction was warmed to reflux and maintained under reflux conditions for 2 hours. After the reaction was stopped, cooled to room temperature, filtered to remove the solid in the system, the filtrate was concentrated by column chromatography (eluent: ethyl acetate: petroleum ether = 1: 100) to obtain 1.60 g of 1-phenyl-3-bromo methyl -1H- pyrazole as a white solid in 70% yield.

The synthetic route of 1128-54-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1128-54-7, name is 3-Methyl-1-phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1128-54-7, 1128-54-7

To the reaction flaskwas added 3-methyl-1-phenyl -1H- pyrazole (0.50 g, 0.003 mol), 5 ml of toluene,heated to 70 C, the reaction solution was added N- bromosuccinimide (0.40 g,0.003 mol), azobisisobutyronitrile (catalytic amount), plus Was completed, thereaction solution was warmed to reflux, the reaction was refluxed for 1 hour.After the reaction was cooled to below 30 C, the reaction solution was pouredinto 50 ml Liters of water with 3 ¡Á 50 ml of ethyl acetate and extracted, theresultant organic phase was washed with saturated aqueous sodium bicarbonate(50 ml), saturated After aqueous sodium chloride solution (50 ml), dried overanhydrous magnesium sulfate, and concentrated under reduced pressure, theresidue was purified by column chromatography (Eluent: ethyl acetate: petroleumether = 1: 100) to give 0.40 g of 3-bromo-1-phenyl -1H- pyrazole as a yellowoil, yield 56 %.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-1-phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.