Category: 92525-10-5

Reference of 92525-10-5, The chemical industry reduces the impact on the environment during synthesis 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Step 1-Synthesis of 2-(1-methyl-1H-pyrazol-3-yl)-4-(trimethylsilyl)but-3-yn-2-ol To a solution of 3-iodo-1-methyl-1H-pyrazole (378 mg, 1.82 mmol) in dry DCM (15 mL) at 0 C. under an atmosphere of nitrogen, was introduced ethylmagnesium bromide (2.0 mL of a 1.0M solution in THF, 2.0 mmol). After 30 minutes at 0 C., the reaction mixture was warmed to RT for 15 minutes, then introduced to a solution of 4-(trimethylsilyl)but-3-yn-2-one (0.37 ml, 2.18 mmol) in dry DCM (5 ml) at 0 C. under an atmosphere of nitrogen. The reaction mixture was warmed to RT for 16 hr. Following addition of saturated aqueous ammonium chloride (5 ml), the reaction mixture was extracted with DCM (3*5 mL extractions). The combined organic extracts were dried (Na2SO4), filtered and concentrated in vacuo. Purification of the residue by silica gel flash column chromatography (heptane/EtOAc gradient) furnished the title compound as an orange-brown oil: 1H NMR (500 MHz, CDCl3) delta 0.15 (9H, d, J=3.5 Hz), 1.82 (3H, s), 3.18 (1H, s), 3.86 (3H, s), 6.28 (1H, d, J=2.2 Hz), 7.26 (1H, d, J=2.2 Hz); LC-MS: m/z=+222.95 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 92525-10-5, The chemical industry reduces the impact on the environment during synthesis 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of 5-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)-1-((2-(trimethylsilyl)- ethoxy)methyl)-1H-1,2,4-triazole-3-thiol (Intermediate B9) (230 mg, 417.01 mumol, 1 eq), 3-iodo-1-methyl-1H-pyrazole (86 mg, 417.01 mumol, 1 eq), CuI (158 mg, 834.02 mumol, 2 eq) and N,N’-dimethylethane-1,2-diamine (735 mg, 8.34 mmol, 20 eq) in dioxane (4 mL) was stirred at 70C under N2atmosphere for 2 hours. The reaction mixture was poured into water (10 mL) and extracted with EtOAc (3 × 10 mL). The organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by prep-TLC (SiO2, petroleum ether: ethyl acetate, 1:1) to give the title compound (170 mg, 82.7% yield, 98% purity on LCMS) as a yellow solid.1H NMR (400 MHz, CDCl3): d 7.34 (d, 1H), 6.94 (s, 1H), 6.47 (d, 1H), 6.18 (s, 1H), 5.31 (s, 2H), 3.90 (s, 3H), 3.61 (t, 2H), 2.87 (t, 4H), 2.69 (t, 4H), 2.09-2.00 (m, 4H), 1.00- 0.88 (m, 2H), 0.02 (s, 9H).LCMS: m/z 483.2 (M+H)+(ES+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 92525-10-5, A common heterocyclic compound, 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) To a solution of 4-((benzyloxy)methyl)pyrrolidin-2-one (836 mg), 3-iodo-1-methyl-1H-pyrazole (856 mg), copper(I) iodide (80 mg) and tripotassium phosphate (1.7 g) in cyclopentyl methyl ether (20 mL) was added N1,N2-dimethylethane-1,2-diamine (87 muL). The reaction mixture was stirred at 120 C. for 22 hr, and diluted with ethyl acetate, and saturated aqueous ammonium chloride solution was added thereto. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.1 g). MS (ESI+): [M+H]+286.3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H5IN2

A suspension of tert-butyl (3S)-3-methyl-5-oxo-piperazine-1 -carboxylate (see Example 73, step b) (280 mg, 1.31 mmol) and 3-iodo-1-methyl-1 H-pyrazole (326 mg, 1.57 mmol) in dioxane (10 ml) was prepared and argon was bubbled for 10 minutes. K3P04 (610 mg, 2.87 mmo), copper (I) iodide (25 mg, 131 pmol) and N,N’-dimethylethylenediamine (28.1 muIota, 261 pmol) were added. The mixture was heated to 120 C for 20 h. The mixture was filtered, the soiids washed twice with ethyl acetate and the filtrate was evaporated. The residue was purified by flash chromatography (EtOAc in heptane 20% to 100%) to afford the title compound (287 mg, 75%) as a light yellow solid. (1042) MS (ESI, m/z): 295.2 [(M+H)+].

The synthetic route of 92525-10-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92525-10-5, name: 3-Iodo-1-methyl-1H-pyrazole

Into a 50-mL vial purged and maintained with an inert atmosphere of nitrogen, 3- iodo-1-methyl-1H-pyrazole (500 mg, 2.40 mmol) was dissolved in acetonitrile (10 mL). Then methyl prop-2-enoate (2.07 g, 24.03 mmol), palladium diacetate (108 mg, 0.48 mmol), tri-ortho- tolylphosphine (292 mg, 0.96 mmol) and triethylamine (1.216 g, 12.02 mmol) were added. The resulting solution was stirred for 2 h at 80oC under nitrogen atmosphere. The reaction mixture was cooled and concentrated under vacuum. The residue was subjected to purification by FCC eluting with ethyl acetate/petroleum ether (1:1). This afforded the title compound (130 mg, 33%) as a yellow oil. MS: (ES, m/z): 167[M+H]+.

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A common compound: 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 92525-10-5

General procedure: To the solution of protected pyrazole 2a-c, 7a, 8a, 12a, 17, 18 or 10a (1 mmol) in 2 mL of dry THFPdCl2(PPh3)2 (14.04 mg, 0.02 mmol) and triethylamine (0.25 g, 2.5 mmol) were added. Reactionmixture was flushed with argon and acetylene (1.2 mmol) were added to the reaction mixturedropwise, following by addition of CuI (1.9 mg, 0.01 mmol) and left to stir at room temperatureovernight. 5 mL of deionized water were added to the reaction mixture, organic layer was separatedand product was extracted with dichloromethane (2 ¡Á 5 mL), organic layers were combined andwashed with 5 mL of water, dried with anhydrous Na2SO4 and evaporated under reduced pressure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 92525-10-5, other downstream synthetic routes, hurry up and to see.