Category: 5932-27-4

5932-27-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

b. 4-Iodo-1H-pyrazole-3-carboxylic acid ethyl ester (Intermediate 74b) A suspension of Intermediate 74a (5.00 g, 35.7 mmol) in acetonitrile (90 mL) was treated with iodine (9.10 g, 35.7 mmol) then ceric ammonium nitrate (19.6 g, 35.7 mmol) and the mixture was stirred at RT overnight. Another portion of iodine (2.28 g, 9.0 mmol) was added and the mixture was stirred for a further 24 h then treated with ice-cold aqueous sodium hydrogensulphite solution (5%, 100 mL). The mixture was filtered through Celite rinsing with EtOAc and water. The phases were separated and the aqueous phase was extracted with EtOAc (2*). The combined organic layers were washed with water and brine, dried (Na2SO4), filtered and evaporated in vacuo. The resulting solid was triturated with ether/cyclohexane, filtered off, washed with cyclohexane and dried at 50 C. in vacuo to give the title compound (3.70 g, 39%). LCMS (Method 3): Rt 2.88 min, m/z 267 [MH+] (weak).

The synthetic route of 5932-27-4 has been constantly updated, and we look forward to future research findings.

5932-27-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

R – (+) – propylene oxide (3.65 g) and After 4-amino-benzotrifluoride ethanol solution of chloride (7.78 mL) (10 mL) was stirred for 4 hours at room temperature, lithium bromide (1.64 g), R – (+) – was stirred 9 days at room temperature was added propylene oxide (1.66 g). The reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (n- hexane / ethyl acetate) to give the title compound (10.5 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding some certain compound to certain chemical reactions, such as: 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5932-27-4. 5932-27-4

A mixture of 3-[4-(bromomethyl)phenyl]-5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]- 1 ,2,4-oxadiazole (338mg, crude), ethyl 1 /-/-pyrazole-3-carboxylate (47mg, 0.333mmol) and potassium te/f-butoxide (41 mg, 0.366mmol) was stirred in ethanol (3.3ml) at 6O0C. The reaction was monitored by LCMS. After 5 hours the reaction mixture was evaporated to dryness, the residues were partitioned between ethyl acetate (45ml) and water (20ml). The organic phase was separated, washed with brine (20ml), dried with magnesium sulphate, filtered and evaporated to dryness. This produced 300mg of orange oil, which was purified on silica, eluting with pentane and ethyl acetate (0 to 90percent gradient). The appropriate fractions were combined and evaporated to dryness. Two isomers were isolated. D3a was obtained as a white solid (30mg, 17percent over 2 steps).1H-NMR (CDCI3): delta 1.34 (3H, t), 4.31 (2H, q), 5.85 (2H, s), 6.91 (1 H, s), 7.36 (2H, d), 7.46 (5H, m), 7.58 (1 H, s), 7.89 (1 H, s), 8.08 (2H, d). MS: m/z (M+H)+ 525, C26H19F3N4O3S requires 524.63mg of yellow oil was also obtained, which was purified on a MDAP. The appropriate fractions were combined and evaporated to dryness, producing D3b as a white solid (48mg, 27percent over 2 steps).1H-NMR (CDCI3, 400MHz): delta 1.41 (3H, t), 4.43 (2H, q), 5.49 (2H, s), 6.87 (1 H, s), 7.36 (2H, d), 7.41 (1 H, s), 7.46 (5H, m), 7.90 (1 H, s), 8.13 (2H, d). MS: m/z (M+H)+ 525, C26H19F3N4O3S requires 524.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ethyl 1H-pyrazole-3-carboxylate.

5932-27-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of tert-butyl ((2-chloro-6-((4,4- difluorocyclohexyl)amino)pyrimidin-4-yl)methyl)carbamate [003 ij (4.2 g, 15.178 mmol) and ethyl-1H-pyrazole-3-carboxylate [0005j (4.2 g, 15.178 mmol) in acetonitrile was added cesium carbonate (4.2 g, 15.178 mmol) and the reaction mixture was heated at 85 ¡ãC in sealed tube. After 2 h, the reaction mixture was filtered, washed with chloroform (50 mL). The combined filtrate was concentrated under reduced pressure to afford pale brown oil which was purified by column chromatography using 35percent ethyl acetate in hexane as eluent to afford ethyl 1 -(4-(((tert-butoxycarbonyl)amino)methyl)-6-((4,4- difluorocyclohexyl)amino)pyrimidin-2-yl)- 1 H-pyrazole-3 -carboxylate [0032j as a pale yellow solid (2.2 g). MS(M+1)=481.3.

The synthetic route of 5932-27-4 has been constantly updated, and we look forward to future research findings.

5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 5932-27-4

General procedure: To a suspension of NaH (60percent) (229 mg, 1.91 mmol) in DMF (10 mL) under nitrogen atmosphere a solution of Preparation 21 (660 mg, 1.91 mmol) in DMF (8 mL) was added. The mixture was stirred at room temperature for 30 min and then ethyl 2-bromo-2,2-difluoroacetate (586 muL, 3.81 mmol) in DMF (8 mL) was added and the reaction mixture stirred overnight at r.t. Solvent was removed and the residue was dissolved in ethyl acetate, washed with water and brine, dried over magnesium sulphate and concentrated. The crude was purified according to the General Purification Method to give the desired compound (10percent yield). LRMS: m/z 469 (M+1)+ Retention time: 7.77 min (Method B); Obtained (35percent) from Preparation 172 and iodoethane following the procedure described in Preparation 23, using dioxane as solvent. LRMS: m/z 169 (M+1)+ Retention time: 2.40 min (Method A) 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.38 (t, J=7.23 Hz, 3 H) 1.44 (t, J=7.23 Hz, 3 H) 4.35 (q, J=7.16 Hz, 2 H) 4.61 (q, J=7.29 Hz, 2 H) 6.83 (d, J=1.95 Hz, 1 H) 7.48 (d, J=1.95 Hz, 1 H).

Statistics shows that 5932-27-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 1H-pyrazole-3-carboxylate.