Category: 120068-79-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, A new synthetic method of this compound is introduced below., 120068-79-3

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

120068-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120068-79-3 as follows.

5-Amino-3-cyano-4-dichlorofluoromethylthio-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole, m.p. 178-180C in the form of a white solid, after purification by chromatography eluding with diethyl ether/hexane (1:1); from 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole. By proceeding in a similar manner but employing a molar equivalent of pyridine in the reaction solution there was obtained:

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 120068-79-3, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, A new synthetic method of this compound is introduced below., 120068-79-3

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

120068-79-3, Name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, 120068-79-3, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

In a reaction vessel equipped with a mechanical stirrer, a thermometer, a dropping device, and a reflux condenser, nitrogen in the reaction vessel was thoroughly replaced with nitrogen, and then 176 g (0.55 mol) 5-amino-3-cyano-1- (2,6-dichloro-4-trifluoromethylphenyl)pyrazole and 800g chloroform solution (the solution was fully dried over anhydrous sodium sulfate, the amount of desiccant is 500% of the theoretical amount required for the formation of complete hydrate from the free water of sodium sulfate and the system, and the desiccant is filtered and filtered) an additional 130 g (0.60 mol) of the dried salt of p-toluenesulfonic acid dimethylamine, the test solution has a water content of 250ppm (system contains about 0.28g, S Jie 15.4mmol7jO, add 1.18g (7.7mmol) of phosphorus oxychloride,Stirring at room temperature 0.5h, the test solution has a water content of less than 50ppm, achieve moisture control standards, the system was cooled to 0 C, 88.5g (0.58mol) of trifluoromethanesulfonyl chloride was added dropwise and evaporated to dryness, and the temperature was raised to the reflux temperature at the end of the dropwise addition. The raw materials of the pyrazole intermediate disappeared after refluxing for 5h and the temperature was lowered to 10 C, add water 200ml, stirred 0.5h, liquid separation, the organic phase was washed with saturated sodium bicarbonate solution, washed with water, the organic phase was separated, the chloroform was distilled off to obtain fipronil crude. The crude product was recrystallized from toluene to give fipronil 198g, purity 98.5%, the total yield of 81%

Statistics shows that 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile is playing an increasingly important role. we look forward to future research findings about 120068-79-3.

120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 120068-79-3

General procedure: To the above acetonitrile solution of cyhalothroyl isothiocyanate 6, 20 mmol 3(a-t) was added and the reaction mixturewas kept under reux for 10 h. Process of the reaction was monitored by TLC(petroleum/ethyl acetate= 2:1). After the reaction,the solvent was evaporated under vacuum and the precipitatedsolid was recrystallized by methanol to get target compounds7(a-t).

Statistics shows that 120068-79-3 is playing an increasingly important role. we look forward to future research findings about 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile.

A common compound: 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 120068-79-3

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 120068-79-3, other downstream synthetic routes, hurry up and to see.

120068-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120068-79-3 as follows.

Further comparative experiments are conducted employing the following preparation procedure; To a 750 ml reactor with a mechanical stirrer and a thermometer containing the amine acid complex (1.5 eq.), 147 g anhydrous toluene (6.5 eq.), and 44.8 g CF3SOCI (1.2 eq.) under an argon atmosphere at 0 0C was added vacuum dried 5-amino-1-(2,6- dichloro-4-trifluoromethyl-phenyl)-1 H-pyrazole-3-carbonitrile (1 eq., 79.5 g, 245 mmol, 99 % purity). The reaction mixture was kept at 5 0C for 60 min and then heated to 35 0C within 45 min. The temperature of 35 0C was kept for another 10 hours before quenching the reaction with 200 g of sodium hydroxide solution (10 wt.%). The resulting suspension was diluted with 176 ml of ethylacetate. After phase separation the organic layer was washed once with sodium hydroxide solution (10 wt.%). After phase separation, the organic layer was analyzed by quantitative HPLC. The product was crystallized from a mixture of ethylacetate and toluene affording the title compound as a white crystalline powder.

According to the analysis of related databases, 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 120068-79-3

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

The synthetic route of 120068-79-3 has been constantly updated, and we look forward to future research findings.