Category: 402-61-9

Related Products of 402-61-9, A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 14; 5 -Methyl- lH-pyrazole-3-carboxylic acid [2-methyl-4-(2(2S)-methyl- [1 ,3′(3 ‘ S)]bipyrrolidinyl- 1 ‘-yl)-phenyl] -amide; 2-Methyl-4-(2(2S)-methyl-[l,3′(3’S)]bipyrrolidinyl-r-yl)-phenylamine (330 mg, 1.15 mmol) was dissolved in DCM (6 mL) and DMF (2 mL), and the solution was cooled in an ice- water bath. To this solution was added powdered 5 -methyl- lH-pyrazole-3-carboxylic acid (174.6 mg, 1.38 mmol, 1.2 equiv.), N-methylmorpholine (280mg, 3 equiv.), 1- hydroxylbenzotriazole (HOBT) (0.162 g, 1.19 mmol, 1.3 equiv.), sequentially, and finally EDC HCl (0.228 g, 1.19 mmol, 1.3 equiv.). The resulting clear brown solution was stirred at r.t. overnight. TLC (10% MeOH in DCM) and LC/MS showed that the reaction was complete and the product peak (368) was detected. The reaction was quenched with saturated sodium bicarbonate aqueous solution (3 mL) and 3 mL of DCM. The two layers were separated, and the aqueous layer was extracted with DCM (5 mLx2). The combined DCM extracts were washed with sodium bicarbonate (5mL) and brine (5 mL), dried (anhydrous potassium carbonate), filtered, and concentrated in vacuo to obtain a crude product which was purified on a silica gel column (25 g of silica gel) on Analogix to obtain the title compound as a tan solid, 207 mg (49% yield).LCMS: Rx = 1.61 minutes, MS: 368 (M+H).1H NMR (300MHz, CDCl3), delta (ppm): 8.3 ((bs, IH), 7.65 (d, 9.6Hz, IH), 6.64 (s, IH), 6.43-6.39 (m, 2H), 3.52 (m, IH), 3.39 (m, IH), 3.26 (m, 2H), 3.02 (m, IH), 2.78 (m, IH), 2.53 (q,8.1Hz, IH), 2.37 (s, 3H), 2.28 (s, 3H), 2.12 (m, IH), 1.98 (m 2H), 1.78 (m, 2H), 1.51 (m, 2H).

The synthetic route of 402-61-9 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2

A mixture of 5-methyl-1H-pyrazole-3-carboxylic acid (27) (150 mg, 1.19 mmol), EDCI¡¤HCl (228 mg, 1.19 mmol), HOBt¡¤H2O (182 mg, 1.19 mmol) and DIPEA (0.20 mL, 1.19 mmol) in DMF was cooled to 0 C and 3,3′,5,5′-tetrakis(aminomethyl)-2,2′,4,4′,6,6′-hexamethyldiphenylmethane (22) (100 mg, 0.27 mmol), dissolved in DMF (3 mL), was added dropwise. The reaction mixture was stirred for 5 days at room temperature and afterwards poured into ice water (80 mL), the formed precipitate filtered off, washed thoroughly with distilled water and dried in the desiccator to constant mass. The desired compound was obtained as a white solid (180 mg, 83%), mp 216 C. 1H NMR (400 MHz, CD3OD): delta 6.46 (s, 4H), 4.57 (s, 8H), 4.23 (s, 2H), 2.39 (s, 6H), 2.28 (s, 12H), 2.10 (s, 12H) ppm. 13C NMR (100 MHz, CD3OD): delta 164.60, 147.86, 141.94, 139.39, 137.51, 135.77, 133.58, 105.48, 39.79, 34.29, 17.38, 16.22, 10.46 ppm. HRMS (ESI) calcd for C43H52N12O4Na [M+Na]+ 823.41267, found 823.41306.

According to the analysis of related databases, 402-61-9, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9

General procedures for Example 168-185; To a solution of 168a (13 mg, 0.02 mmol) in DMA in a 4 ml vial was added the acid monomer (0.025 mmol) dissolved in DMA followed by a solution of HATU (0.025 mmol) in DMA and then triethylamine (0. 4 mmol) neat. The vial was capped and microwaved at 150 C for 30 minutes. The reaction was checked by LC/MS and concentrated to dryness. The residue was dissolved in MeOH:DMSO (1:1 v:v, 1.5 ml) and purified by reverse phase HPLC.HPLC condition: Samples were purified by preparative HPLC on a Phenomenex Luna C8(2) 5 um 100A AXIA column (30mm x 75mm). A gradient of methanol (A) and 0.1%trifluoroacetic acid in water (B) was used, at a flow rate of 50mL/min (0-0.5 min 20% A, 0.5- 6.0 min linear gradient 20-100% A, 6.0-7.0 min 100% A, 7.0-8.0 min linear gradient 100- 10% A).; Example 168; (2R,6S,13aS,14aR,16aS,Z)-2-(3-ethyl-8-fluoroquinoxalin-2-yloxy)-6-(5-methyl-lH- pyrazole-3-carboxamido)-N-(l-methylcyclopropylsulfonyl)-5,16-dioxo- 1, 2,3,5, 6,7, 8,9, 10,11, 13a,14,14a,15, 16, 16a-hexadecahydrocyclopropa[e]pyrrolo[l, 2- a] [ 1 ,4] diazacyclopentadecine- 14a-carboxamide; The title compound 168 was prepared according to the general procedure used for Example 168-185 using 5-methyl-lH-pyrazole-3-carboxylic acid as the acid monomer. MS (ESI): m/z = 765.3 [M+H].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 402-61-9.

402-61-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

502 mg (2.62 mmol) of EDC, 401 mg (2.62 mmol) of HOBt and 500 mg (2.38 mmol) of the compound from Example 6A/Step 3 were added successively at RT to a solution of 300 mg (2.38 mmol) of 5-methyl-1H-pyrazole-3-carboxylic acid in 10 ml of anhydrous DMF. The mixture was stirred first at RT for 16 h and then at 140 C. for 45 min. After cooling, the solvent was removed on a rotary evaporator. 120 ml of water were added to the remaining residue, which was extracted three times with approx. 100 ml each time of diethyl ether. The combined organic extracts were washed with saturated sodium chloride solution, dried over anhydrous magnesium sulphate, filtered and finally concentrated on a rotary evaporator. The crude product was stirred with 5 ml of ethanol at RT for 1 h. After filtering and drying the undissolved solid under high vacuum, a first fraction of 204 mg of the title compound was obtained. The mother liquor was concentrated to dryness. Subsequently, a further fraction of 29 mg of the title compound was isolated from the residue by means of preparative HPLC (method 13). In total, 233 mg (33% of theory) of the title compound were thus obtained.1H NMR (400 MHz, CDCl3, delta/ppm): 8.27 (d, 2H), 7.72 (d, 2H), 6.81 (s, 1H), 5.05 (dd, 2H), 5.01 (dd, 2H), 2.47 (s, 3H).LC/MS (method 2, ESIpos): Rt=1.93 min, m/z=301 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9.

A solution of Pb(OAc)2¡¤3H2O (0.0379 g, 0.1 mM) in water (3 mL) was added to a solutionof H2MPCA (0.0126 g, 0.1 mM) in 6 mL of a 1 : 1 (v : v) EtOH and water and stirred for 1h. The resulting solution was evaporated at room temperature. Colorless crystals of 1(0.0178 g, 78%) suitable for single-crystal X-ray diffraction analysis were obtained after one day.

The synthetic route of 5-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9.

General procedure: To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (19; 1.1-3.3 equiv) in DMF (5 mL) were added EDCI¡¤HCl (1.1-3.3 equiv), HOBt¡¤H2O (1.1-3.3 equiv) and DIPEA (1.1-3.3 equiv) at 0 C and the resulting mixture was stirred at this temperature for 30 min. The corresponding derivative bearing one to three amino groups (17, 25-28 or 36; 1 equiv), dissolved in DMF (1 mL), was added and the reaction mixture was stirred for 48 h at r.t. After this time, the reaction mixture was poured into ice-water (30 mL) and the formed precipitate was filtered off and washed thoroughly with small amounts of distilled H2O to free it from DMF. After drying in a dessicator, the desired products were obtained as white solids.

The synthetic route of 5-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9.

[(VIVO)(C5H5N2O2)2H2O]2H2O (2) VO(acac)2 (0.0265 g,0.1 mmol) and 5-pyrazol-1H-pyrazol-3-carboxylic acid (0.025 g,0.2 mmol) were mixed and stirred for 3 h in a solution of 95%methanol (8 mL) at room temperature. After two days, purplecrystals of complex were obtained. Yield (based on V): 0.036 g,48.78%. Anal. Calc. For C10H16N4O8V: C, 32.35; H, 4.3; N, 15.09.Found: C, 32.35; H, 4.28; N, 15.05.

The synthetic route of 5-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

402-61-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 13 beta-{4-[2-(5-Methylpyrazole-3-carboxamido)-ethyl]-phenyl}-propionic acid 1.27 ml. triethylamine and 0.85 ml. ethyl chloroformate are added at -10 C. to a solution of 1.12 g. of 5-methylpyrazole-3-carboxylic acid in 25 ml. anhydrous tetrahydrofuran. After 15 minutes, a further 1.27 ml. triethylamine is added and then 2.57 g. ethyl beta-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride. The reaction mixture is stirred for 1 hour at +20 C., filtered with suction and the filtrate is evaporated and the residue taken up in methylene chloride. After extraction with 2N hydrochloric acid, 2N aqueous sodium hydroxide solution and neutralization, the solution is dried and evaporated. The crude ester thus obtained is heated under reflux for 1 hour with 0.6 g. sodium hydroxide in 30 ml. ethanol. After cooling, the precipitated sodium salt is filtered off with suction, dissolved in water and carefully acidified. The precipitate obtained is filtered off and recrystallized from 20% ethanol. There is obtained beta-{4-[2-(5-methylpyrazole- 3-carboxamido)-ethyl]-phenyl}-propionic acid in a yield of 22% of theory; m.p. 202-205 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

402-61-9, Name is 5-Methyl-1H-pyrazole-3-carboxylic acid, 402-61-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (45 g) in MeOH (450 mL) is added dropwise thionylchloride (58 mL). After addition the mixture is stirred for 16 h at room temperature. The mixture is concentrated in vacuo. The residue is dissolved in EtOAC, washed successively with saturated aqueous NaHCO3 and brine. After drying (MgSO4) the mixture is concentrated in vacuo to give the title compound. LC (Method 1): tR=0.64 min; Mass spectrum (ESI+): m/z=141 [M+H]+.

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., 402-61-9

To 4 g (30 mmoles) of 5-methyl pyrazole 3-carboxylic acid are added 7.1 g (60 mmoles) of thionyl chloride, 150 ml of toluene and several drops of DMF. To the product obtained are then added 7.7 g of 2,6-dimethyl aniline (60 mmoles), 200 ml of toluene and again a few drops of DMF. 2.60 of the title product are obtained in the form of ochre crystals. Yield: 37.8% M.p. 190 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.