Category: 402-61-9

Adding a certain compound to certain chemical reactions, such as: 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 402-61-9, Formula: C5H6N2O2

Step C: N-rr4i?)-6-r4-Chlorophenvn-7-(2.4-dichlorophenvn-2.2-dimethyl-3.4-dihvdro-2//- pyrano [2,3-frlrhoyridin-4-yll -5 -methyl- 1.H-pyrazole-3 -carboxamide; . A mixture of the product of Step B (300 mg, 0.69 mmol), S-methylpyrazole-S-carboxylic acid (105 mg, 0.83 mmol), PyBOP (540 mg, 1.04 mmol), and NEt3 (0.19 mL, 1.38 mmol) in 20 mL Of CH2Cl2 was stirred at rt. After 16 h, the reaction mixture was diluted with Et2O (50 mL), washed with saturated aq NaHCO3 (3×50 mL) and brine (3×50 mL). The organic layer was separated, dried over MgSO4 and concentrated. Chromatography on a Biotage 40+S cartridge using 1 : 1 v/v EtOAc/Hexanes as the eluant afforded the title compound: 1H NMR delta 1.44 (s, 3H), 1.51 (s, 3H), 1.94 (t, J= 12.5, IH), 2.26-2.30 (m, 4H), 5.62 (m, IH), 6.58 (s, IH), 6.96 (d, J= 8.5, 2H), 7.12-7.29 (m, 5H), 7.69 (s, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK & CO., INC.; WO2008/94476; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 402-61-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

In similar way, Cu(ClO4)26H2O (2.25mmol, 0.83g) in 20mL dry methanol is mixed with a dry methanolic solution (15mL) of Hmpca (5mmol, 0.63g). The resulting solution is refluxed for 4h; slow evaporation of the solution at room temperature furnished blue crystalline compound which is filtered off, washed with methanol and dried over silica gel. The yield is 0.51g (68%) for [Cu(mpca)2]H2O( 2). Elemental analysis for 2 (when n1) (C10H12CuN4O5): Calculated: C, 36.16; H, 3.61; N, 16.87 and Found: C, 36.29; H, 3.42; N, 16.91. IR assignments (in cm1): m(CN) (1369), m(C-N) (1285), m(N-N) (1034) and m(C-O) (1550).

The chemical industry reduces the impact on the environment during synthesis 5-Methyl-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Article; Santra, Ananyakumari; Brandao, Paula; Jana, Harekrishna; Mondal, Gopinath; Bera, Pradip; Jana, Abhimanyu; Bera, Pulakesh; Journal of Coordination Chemistry; vol. 71; 22; (2018); p. 3648 – 3664;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 402-61-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

23.3 g (0.121 mol) of EDC, 16.4 g (0.121 mol) of HOBt and 26.7 g (0.121 mol) of N’-hydroxy-4-(trifluoromethoxy)benzenecarboximide amide were added successively to a solution of 15.3 g (0.121 mol) of 5-methyl-1H-pyrazole-3-carboxylic acid in 600 ml of anhydrous DMF at RT. The mixture was stirred first at RT for 2 h and then at 140 C. for 5 h. After cooling, the mixture was diluted with 2 litres of water and extracted three times with 1 litre of ethyl acetate each time. The combined organic extracts were washed successively with water and saturated sodium chloride solution. After drying over anhydrous magnesium sulphate, the mixture was filtered and the solvent was removed on a rotary evaporator. The crude product obtained was purified by means of filtration with suction over a suction filter filled with silica gel (eluent: cyclohexane/ethyl acetate 5:1?1:1). The product fractions were combined and the solvent was removed on a rotary evaporator to such an extent that the product just started to precipitate out. The precipitation was brought to completion at RT. By filtration and further concentration of the mother liquor, two fractions of solid were obtained, which were combined and dried under a high vacuum. 19.7 g (52% of th.) of the title compound were obtained in total in this way.1H-NMR (400 MHz, CDCl3, delta/ppm): 10.75 (broad, 1H), 8.24 (d, 2H), 7.34 (d, 2H), 6.81 (s, 1H), 2.46 (s, 3H).HPLC (method A): Rt=4.72 min.MS (DCI, NH3): m/z=311 [M+H]+.LC/MS (method F, ESIpos): Rt=1.27 min, m/z=311 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2

Example 17A5-(5-Methyl-1H-pyrazol-3-yl)-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole; 23.3 g (0.121 mol) of EDC, 16.4 g (0.121 mol) of HOBt and 26.7 g (0.121 mol) of N’-hydroxy-4-(trifluoromethoxy)benzenecarboximidamide were added successively to a solution of 15.3 g (0.121 mol) of 5-methyl-1H-pyrazole-3-carboxylic acid in 600 ml of anhydrous DMF at RT. The mixture was stirred first at RT for 2 h and then at 140 C. for 5 h. After cooling, the mixture was diluted with 2 litres of water and extracted three times with 1 litre of ethyl acetate each time. The combined organic extracts were washed successively with water and saturated sodium chloride solution. After drying over anhydrous magnesium sulphate, the mixture was filtered and the solvent was removed on a rotary evaporator. The crude product obtained was purified by filtration with suction over a suction filter filled with silica gel (eluent: cyclohexane/ethyl acetate 5:1?1:1). The product fractions were combined and the solvent was removed on a rotary evaporator to such an extent that the product just started to precipitate out. The precipitation was brought to completion at RT. By filtration and further concentration of the mother liquor, two fractions of solid were obtained, which were combined and dried under high vacuum. 19.7 g (52% of theory) of the title compound were obtained in total in this way.1H-NMR (400 MHz, CDCl3, delta/ppm): 10.75 (broad, 1H), 8.24 (d, 2H), 7.34 (d, 2H), 6.81 (s, 1H), 2.46 (s, 3H).HPLC (method A): Rt=4.72 min.MS (DCI, NH3): m/z=311 [M+H]+.LC/MS (method F, ESIpos): Rt=1.27 min, m/z=311 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 402-61-9.

Reference of 402-61-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 402-61-9 name is 5-Methyl-1H-pyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1 lambda/-[6-(1H-lndol-4-yl)-1H-indazol-4-yl]-5-methyl-1H-pyrazole-3-carboxamide 5-Methyl-1 H-pyrazole-3-carboxylic acid (10mg) in DMF (0.2ml) was treated with N- [(dimethylamino)(3H-[1 ,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-/V- methylmethanaminium hexafluorophosphate (27mg) in DMF (0.2ml) and DIPEA (0.03ml). The reaction mixture was shaken for five min prior to treatment with 6-(1H-indol-4-yl)-2- (tetrahydro-2H-pyran-2-yl)-2H-indazol-4-amine (20mg) in DMF (0.2ml). The reaction mixture was shaken for five min and left to stand at 220C for 18h. The solvent was removed in vacuo and the product re-dissolved in methanol (1 ml) prior to application on to an SCX SPE cartridge (1g). The product was eluted after 1 h with 2M ammonia in methanol (2x3ml), the fractions were combined and concentrated under a stream of nitrogen using blow down apparatus. Purification by mass directed preparative HPLC (Method C) afforded the title compound. LC/MS R1 2.91 min m/z 357 [MH+]. Method A

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H6N2O2

General procedure: To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (19; 1.1-3.3 equiv) in DMF (5 mL) were added EDCI·HCl (1.1-3.3 equiv), HOBt·H2O (1.1-3.3 equiv) and DIPEA (1.1-3.3 equiv) at 0 C and the resulting mixture was stirred at this temperature for 30 min. The corresponding derivative bearing one to three amino groups (17, 25-28 or 36; 1 equiv), dissolved in DMF (1 mL), was added and the reaction mixture was stirred for 48 h at r.t. After this time, the reaction mixture was poured into ice-water (30 mL) and the formed precipitate was filtered off and washed thoroughly with small amounts of distilled H2O to free it from DMF. After drying in a dessicator, the desired products were obtained as white solids.

The synthetic route of 402-61-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 402-61-9, A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 4 g (30 mmoles) of 5-methyl pyrazole 3-carboxylic acid are added 7.1 g (60 mmoles) of thionyl chloride, 150 ml of toluene and several drops of DMF. To the product obtained are then added 7.7 g of 2,6-dimethyl aniline (60 mmoles), 200 ml of toluene and again a few drops of DMF. 2.60 g of the title product are obtained in the form of ochre crystals. Yield: 37.8% M.p.=190 C.

The synthetic route of 402-61-9 has been constantly updated, and we look forward to future research findings.

Reference of 402-61-9, These common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 4.30 g (34.1 mmol) of 5-methyl-1H-pyrazole-3-carboxylic acid in 20 ml of anhydrous DMF was added dropwise at RT within approx. 15 min to a suspension of 5.81 g (35.8 mmol) of 1,1′-carbonyldiimidazole (CDI) in 25 ml of anhydrous DMF. After the mixture had been stirred at RT for 105 min, 8.12 g (34.1 mmol) of the compound from Example 5A/Step 3 were added. Subsequently, the reaction mixture was heated to 110 C. for 5 h. After cooling to RT, the mixture was stirred gradually into 800 ml of water. In the course of this, the product precipitated out. It was filtered off with suction and washed with water. Subsequently, the moist crude product was recrystallized from 430 ml of ethanol. After the solid had been filtered and dried, 8.31 g (74% of theory) of the title compound were obtained. A further fraction was obtained by concentrating the mother liquor (1.69 g with 85% purity, 13% of theory).1H NMR (400 MHz, CDCl3, delta/ppm): 10.73 (broad, 1H), 8.20 (d, 2H), 7.52 (d, 2H), 6.81 (s, 1H), 4.00-3.88 (m, 4H), 2.45 (s, 3H), 2.30-2.11 (m, 2H), 1.98-1.91 (m, 2H).LC/MS (method 1, ESIpos): Rt=4.24 min, m/z=329 [M+H]+.

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.

Related Products of 402-61-9,Some common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 5-methyl-1H-pyrazole-3-carboxylic acid (19; 1.1-3.3 equiv) in DMF (5 mL) were added EDCI¡¤HCl (1.1-3.3 equiv), HOBt¡¤H2O (1.1-3.3 equiv) and DIPEA (1.1-3.3 equiv) at 0 C and the resulting mixture was stirred at this temperature for 30 min. The corresponding derivative bearing one to three amino groups (17, 25-28 or 36; 1 equiv), dissolved in DMF (1 mL), was added and the reaction mixture was stirred for 48 h at r.t. After this time, the reaction mixture was poured into ice-water (30 mL) and the formed precipitate was filtered off and washed thoroughly with small amounts of distilled H2O to free it from DMF. After drying in a dessicator, the desired products were obtained as white solids. 1,3,5-Tris[(5-methyl-1H-pyrazol-3-yl-carbonyl)aminomethyl]-2,4,6-triethylbenzene (6) Yield: 78% (0.11 g, 0.19 mmol); white solid; mp 178 C (dec.). 1H NMR (400 MHz, CD3OD): delta = 6.50 (s, 3 H), 4.65 (s, 6 H), 2.85 (q, J =7.5 Hz, 6 H), 2.29 (s, 9 H), 1.20 (t, J =7.5 Hz, 9 H). 13C NMR (100 MHz, CD3OD): delta = 164.63, 147.88, 145.72, 142.02,133.02, 105.52, 38.75, 24.05, 16.67, 10.48. HRMS (ESI): m/z [M + H]+ calcd for C30H40N9O3: 574.32486; found: 574.32506.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-pyrazole-3-carboxylic acid, its application will become more common.

Related Products of 402-61-9, These common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step C N-r(4i?V6-(4-Chlorophenvn-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H- pyrano|”2,3-61pyridin-4-yl]-5-methyl-l.H-pyrazole-3-carboxamide.; A mixture of the product of Step B (300 mg, 0.69 mmol), S-methylpyrazole-S-carboxylic acid (105 mg, 0.83 mmol), PyBOP (540 mg, 1.04 mmol), and NEt3 (0.19 mL, 1.38 mmol) in 20 mL of CH2Cl2 was stirred at rt. After 16 h, the reaction mixture was diluted with Et2O (50 mL), washed with saturated aq NaHCO3 (3×50 mL) and brine (3×50 mL). The organic layer was separated, dried over MgSO4 and concentrated. Chromatography on a Biotage 40+S cartridge using 1 : 1 v/v EtOAc/Hexanes as the eluant afforded the title compound: 1H NMR delta 1.44 (s, 3H), 1.51 (s, 3H), 1.94 (t, J= 12.5, IH), 2.26-2.30 (m, 4H), 5.62 (m, IH), 6.58 (s, IH), 6.96 (d, J= 8.5, 2H), 7.12-7.29 (m, 5H), 7.69 (s, IH).

Statistics shows that 5-Methyl-1H-pyrazole-3-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 402-61-9.