Adding some certain compound to certain chemical reactions, such as: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18048-64-1. 18048-64-1
A solution of 3′-amino-2′-hydroxy-1,1′-biphenyl-3-carboxylic acid hydrochloride salt (1.31 g 5.725 mmol) in methanol water, obtained as described in Example 4′, was cooled to 0-5 C and a solution of sodium nitrite (0,403 g, 5.840 mmol) in water (2 ml) was added over 15 minutes. The reaction was stirred at 0-10 C for one hour and then it was heated to 20 C. Triethylamine (about 2,5 ml) was added to bring the pH to 8-9 and 1-(3,4-dimethylphenyl)-3-methyl-1 H-pyrazol-5-ona (1.16 g, 5,725 mmol) was added in one portion. The mixture was stirred for 2 hours at 20 C maintaining the pH 8-9. Hydrochloric acid (4M, about 4 ml) was added to adjust the pH to 1.5-2.0. The precipitate was filtered, washed with water and dried at 40 C to yield 2.492 g (93%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one.