Category: 1134-50-5

Adding a certain compound to certain chemical reactions, such as: 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1134-50-5, category: pyrazoles-derivatives

Procedure: The pyrazole is solubilized in DMF in a reactor under nitrogen and with magnetic stirring. CDI is then rapidly added in a single portion and the mixture is kept stirring for approximately 20 minutes. The amine is then rapidly added dropwise by means of a syringe. After stirring for 3 h 30 min, TLC monitoring of the reaction indicates that the starting product has completely disappeared. The reaction medium is then poured into 80 ml of an ice/water mixture. The white precipitate formed after stirring for 15 minutes is then recovered by filtration through a sintered glass filter and dried by suction. The orangey solid obtained is then taken up in 50 ml of dichloromethane, washed once with water, and dried over sodium sulfate. After filtration through sintered glass filter and evaporation under partial vacuum, 0.8 g of a yellow solid is thus obtained. The latter is chromatographed on silica (elution: 7/3 hexane/ethyl acetate) and then recrystallized from toluene. 0.80 g of a beige solid is thus recovered (yield: 56%). It is characterized in the form of a compound associated with half a molecule of water.

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1134-50-5, The chemical industry reduces the impact on the environment during synthesis 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

General procedure: Example 1-103 1-Phenyl-1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinolin-3-ylmethyl]-amide A mixture of 3-(aminomethyl)-7-fluoro-1-(2-fluorophenyl)quinolin-4(1H)-one (intermediate H) (50 mg, 0.175 mmol), 1 -phenyl- 1H-pyrazole-4-carboxylic acid (66 mg, 0.349 mmol), bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBrOP) (112 mg, 0.24 mmol), triethylamine (53 mg, 0.524 mmol), and DMF (3 mL) was stirred at room temperature overnight. The crude material was purified by flash chromatography (12 g silica gel eluting with 100% hexanes ramped to 70% ethyl acetate in hexanes). The product 1 -phenyl- 1H-pyrazole-4-carboxylic acid [7-fluoro-1-(2-fiuoro-phenyl)-4-oxo-1,4- dihydro-quinolin-3-ylmethyl]-amide (46 mg, 58%) was obtained as an off-white solid. MS calcd. for C22H14CIF2N3O2 [(M+H)+] 426.1, obsd. 426.1.

The chemical industry reduces the impact on the environment during synthesis 1-Phenyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1134-50-5 name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 1134-50-5

[00240j To a solution of 1-phenyl-1H-pyrazole-4-carboxylic acid (590 mg, 3.1 mmol) in THF (6.9 mL) at rt was added borane-THF complex (6.2 mL, 6.2 mmol, 1 M in THF), and the reaction mixture was stirred over night. The mixture was quenched by the slowaddition of 1M NaOH and pouring into water. The mixture was extracted with ether (2x). The combined organics were washed with water and brine, dried over Na2SO4, andconcentrated to give Example 22A a white solid. MS (ESI) m/z 175.1 (M+H). The crude product was used in the next synthetic step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Phenyl-1H-pyrazole-4-carboxylic acid, and friends who are interested can also refer to it.