Category: 35344-95-7

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, belongs to pyrazoles-derivatives compound, is a common compound. In a patnet, author is Abd El-Aal, Hassan A. K., once mentioned the new application about 35344-95-7, COA of Formula: C4H4N2O.

Target-oriented synthesis of functionalized pyrazolo-fused medium-sized N,S-heterocycles via Friedel-Crafts ring closure approach

Efficient and concise synthetic protocol to benzo- and pyrazolo-fused medium-sized N,S-heterocycles (e.g,. thiazocinones, thiazoninones, thiazecinones, thiecinones, and thioninones) is developed. The process involves the AlCl3/MeNO2, TfOH or polyphosphoric acid mediated cyclization of pyrazole-based carboxylic acids or esters into tricyclic ketones under mild conditions. The designed protocol offers easy access to biologically and pharmaceutically promising pyrazoles in good yields. The structure elucidation of all new compounds without stereochemical assignments has been carried out by spectral and elemental analysis.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 35344-95-7. The above is the message from the blog manager. COA of Formula: C4H4N2O.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, SMILES is O=CC1=CNN=C1, belongs to pyrazoles-derivatives compound. In a document, author is Xu, Feng, introduce the new discover, SDS of cas: 35344-95-7.

Selective hydrogenation of nitroaromatics toN-arylhydroxylamines in a micropacked bed reactor with passivated catalyst

In this contribution, a protocol was established for the selective catalytic hydrogenation of nitroarenes to the correspondingN-arylhydroxylamines. The reduction of 1-(4-chlorophenyl)-3-((2-nitrobenzyl)oxy)-1H-pyrazole, an intermediate in the synthesis of the antifungal reagent pyraclostrobin that includes carbon-chlorine bonds, benzyl groups, carbon-carbon double bonds and other structures that are easily reduced, was chosen as the model reaction for catalyst evaluation and condition optimization. Extensive passivant evaluation showed that RANEY (R)-nickel treated with ammonia/DMSO (1 : 10, v/v) afforded the optimal result, especially with a particle size of 400-500 mesh. To combine the modified catalyst with continuous-flow reaction technology, the reaction was conducted at room temperature, rendering the desired product with a conversion rate of 99.4% and a selectivity of 99.8%. The regeneration of catalytic activity was also studied, and an in-column strategy was developed by pumping the passivate liquid overnight. Finally, the generality of the method was explored, and 7 substrates were developed, most of which showed a good conversion rate and selectivity, indicating that the method has a certain degree of generality.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 35344-95-7 is helpful to your research. SDS of cas: 35344-95-7.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, SMILES is O=CC1=CNN=C1, in an article , author is Abu-Hashem, Ameen Ali, once mentioned of 35344-95-7, Recommanded Product: 35344-95-7.

Synthesis and antimicrobial activity of new 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, thiopyrane, thiazolidinone, and azepine derivatives

4-oxo-4-phenylbutanehydrazide3was reacted with aryl or alkyl isothiocyanates to give the correspondingN-substituted-2-(4-oxo-4-phenylbutanoyl) hydrazine-1-carbothioamide4a-c. Cyclization of thiosemicarbazides4a-cwith sodium hydroxide led to the formation of 3-(4-sub-5-thioxo-1,2,4-triazol-3-yl)-propanone5a-c. Desulfurization of thiosemicarbazides4a-cby mercuric oxide afforded 3-(5-(sub-amino)-1,3,4-oxadiazol-2-yl)-propanone6a-c. The reaction of4a-cwith phosphorus oxychloride gave 3-(5-(sub-amino)-1,3,4-thiadiazol-2-yl)-propanone7a-c. Treatment of4a-cwith ethyl-bromoacetate or alpha-bromopropionic acid gaveN ‘-(3-sub-thiazolidin-2-ylidene)-butanehydrazide8a-cand (N ‘-(3-sub-oxothiazolidin-2-ylidene)-butanehydrazide9a-c. Chlorination of oxothiazolidine-hydrazide9a-cby phosphorus oxychloride affordedN-(3-sub-4-oxothiazolidine)-butane-hydrazonoyl-chloride10a-c. The reaction of10a-cwith mercaptoacetyl-chloride yielded 2-((4-benzoyl-thiopyrane) hydrazono)-3-sub-thiazolidinone11a-c. Also, reacted of10a-cwith hydrazine hydrate affordedN ”-(3-sub-oxothiazolidine)-butane-hydrazon-hydrazide12a-c. The 3-sub-2-((pyridazine) hydrazono) thiazolidinone13a-cwas obtained by cyclization of12a-cvia refluxing in DMF. The reaction and cyclized of9a-cwith chloroacetyl-chloride in ethanolic KOH afforded 1-((3-sub-4-oxothiazolidine) amino)-azepine-dione14a-c. The chemical structures of the new compounds have been confirmed by diverse spectroscopy analyses such as IR, NMR, MS, and elemental analysis. The synthesized compounds were tested for their antimicrobial activity and these compounds were considered (Pyridazin-hydrazono-thiazolidinone13a-c, oxothiazolidin-azepinedione14a-c,N-thiazolidin-hydrazon-hydrazide12a-c, and thiopyran-hydrazono-thiazolidinone11a-c) the most effective as antimicrobial activity.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, formurla is C4H4N2O. In a document, author is Wang, Guangcheng, introducing its new discovery. Quality Control of 1H-Pyrazole-4-carbaldehyde.

Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization

A new series of pyrazole-naphthalene derivatives (5a-5q) have been synthesized and evaluated for their anticancer activity against human breast cancer cell lines (MCF-7). Most of newly synthesized compounds (except 5i, 5m, and 5p) exhibited potent antiproliferative activity in the range of IC50 = 2.78 +/- 0.24 mu M – 9.13 +/- 0.47 mu M. Among them, compound 5j (IC50 = 2.78 +/- 0.24 mu M), bearing ethoxy at the 4-position of the phenyl ring, was found to be the most active compound in this series of compounds, with five folds more active than the standard drug cisplatin (IC50 = 15.24 +/- 1.27 mu M). In addition, compound 5j and colchicine showed the same ability to inhibit tubulin polymerization with the IC50 values of 4.6 mu M and 6.7 mu M, respectively. Cellular mechanism studies elucidated that compound 5j arrested the cell cycle at G2/M phase and induced apoptosis. Furthermore, molecular docking analysis revealed that compound 5j formed stable interactions in the colchicine-binding site of tubulin.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 35344-95-7 help many people in the next few years. Quality Control of 1H-Pyrazole-4-carbaldehyde.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, SMILES is O=CC1=CNN=C1, belongs to pyrazoles-derivatives compound. In a document, author is Gogoi, Pinku, introduce the new discover, Quality Control of 1H-Pyrazole-4-carbaldehyde.

In silico study, synthesis, and evaluation of the antimalarial activity of hybrid dimethoxy pyrazole 1,3,5-triazine derivatives

Malaria continues to become a major global health problem, particularly in Sub-Saharan Africa, Asia, and Latin America. The widespread emergence of resistance to first-line drugs has further bolstered an urgent need for a new and cost-effective antimalarial(s). Thus, the present study enumerates the synthesis of novel hybrid dimethoxy pyrazole 1,3,5-triazine derivatives 7(a-j) and their in silico results short-listed three compounds with good binding energies and dock scores. Docking analysis shows that hydrogen-bonding predominates and typically involves key residues, such as Asp54, Tyr170, Ile164, and Arg122. The in vitro antimalarial evaluation of three top-ranked compounds (7e, 7g, and 7h) showed half-maximal inhibitory concentration values range from 53.85 to 100 mu g/ml against chloroquine-sensitive strain 3D7 of Plasmodium falciparum. Compound 7e may be utilized as a lead for further optimization work in drug discovery due to good antimalarial activity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 35344-95-7 is helpful to your research. Quality Control of 1H-Pyrazole-4-carbaldehyde.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35344-95-7

into a 100-mL round-bottom flask, was placed a solution of tert-butyl N-[3-(methanesulfonyloxy)cyclobutyl]carbamate (2.65 g, 9.99 mmol, 1.00 eq.), 1H-pyrazole-4-carbaldehyde (1.152 g, 11.99 mmol, 1.20 eq.) and Cs2CO3 (6.52 g, 20.01 mmol, 2.00 eq.) inDMF (20 mL). The resulting solution was stirred for 4 h at room temperature. The reaction was then quenched by the addition of 100 mL of water. The resulting solution was extracted with 3×100 mL of ethyl acetate and the organic layers combined. The resulting mixture was washed with 100 mL of brine. The mixture was dried over anhydrous sodium sulfate andconcentrated under vacuum. The crude product was purified by Flash-Prep-HPLC with the following conditions (CombiFlash-1): Column, C18 silica gel; mobile phase, MeCN/H20=60:40 increasing to MeCN/H20=70:30 within 3 mm; Detector, UV 254 nm. The crude product was purified by Prep-SFC with the following conditions (prep SFC 350-2):Column: Phenomenex Lux 5u Cellulose-4 250*50mm; mobile Phase A: C02:70, Mobile PhaseB: MeQH-HPLC:30; Flow rate: 150 mL/min; 254 nm; RT1:4.53; RT2:5.36. This resulted in 712 mg (54%) of tert-butyl N-[cis-3 -(4-formyl- 1 H-pyrazol- 1 -yl)cyclobutyl]carbamate as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35344-95-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, Formula: C4H4N2O

A solution of 3-[4-(bromomethyl)phenyl]-5-(trifluoromethyl)-1 ,2,4-oxadiazole (5.0 g, 15.5 mmol),1H-pyrazole-4-carbaldehyde (2.35 g, 23.2 mmol), and potassium carbonate (4.32 g, 30.9 mmol) in acetonitrile (62 mL) were sealed in a vial. The contents were irradiated with microwaves at 130¡ãC for 1 hour. Solids were removed by filtration, washed with ethyl acetate, and the mother liquors were concentrated under reduced pressure. The resultant residue was purified by flash chromatography oversilica gel (cyclohexane:EtOAc eluent gradient 1:0 to 0:1)to afford 362mg of the title compound as a white solid. LC/MS (Method A) retention time = 1.06 minutes, 352 (M+H). mp: 91 – 96¡ãC1H NMR (400 MHz, CDCI3)o ppm: 9.78 (s, 1H), 8.22 (d, 2H), 8.05 (s, 1H), 7.98 (s, 1H), 7.40 (d,2H), 5.40 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Synthetic Route of 35344-95-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35344-95-7 name is 1H-Pyrazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 2,3-diamino-1,4-naphthoquinone (1.0 mmol),appropriate aromatic aldehyde (1.0 mmol) with sodium pyrosulfitein DMF was stirred at 120 C overnight. On completion of the reactionmonitored by TLC, the solvent was evaporated and the residuewas purified by silica gel chromatography by DCM/MeOHsystem to afford the final product. If necessary, the crude productcould be recrystallized in methanol or DMSO to afford pure sample.4.1.5.1. 2-(2-Chlorophenyl)-1H-naphtho[2,3-d]imidazole-4,9-dione(T1). Pale yellow solid; yield 80percent;

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Formula: C4H4N2O

A suspension of 1H-pyrazole-4-carbaldehyde (1.00 g, 10.41 mmol) in DCM (30 mL) was stirred under nitrogen. Triethylamine (1.45 mL, 10.41 mmol) was added resulting in a solution. The reaction was cooled to 0 oC with a cooling bath and benzyl carbonochloridate (1.49 mL, 10.41 mmol) was added as dropwise over 5 min maintaining the internal temperature below 10 oC. The reaction was allowed to stir at 4 oC with a cooling bath for 1 h. An aqueous 1M solution of hydrochloric acid (30 mL) was added cautiously. The layers were separated and the aqueous portion was extracted with DCM (2 x 30 mL). The combined organic extracts were washed with water (20 mL) and brine (20 mL). The combined organic extracts were passed through a phase separation cartridge and concentrated under reduced pressure. The resulting yellow residue was purified by flash silica chromatography eluting with a gradient of 0-50percent EtOAc in heptane. Product containing fractions were concentrated under reduced pressure to afford benzyl 4-formylpyrazole-1-carboxylate (1.78 g, 74percent) as a white solid. IR: 1736 (CO), 1674 (CO) cm-1; 1H NMR (400 MHz, CDCl3) 5.51 (s, 2H), 7.35 ? 7.47 (m, 3H), 7.47 ? 7.55 (m, 2H), 8.15 (s, 1H), 8.57 ? 8.71 (m, 1H), 9.96 (s, 1H); 13C NMR (400 MHz, CDCl3) 71.00, 126.11, 128.90, 129.02, 129.35, 133.62, 135.14, 142.86, 148.56, 183.49; HRMS [M+Na]+ measured 253.0578, C12H10O3N2 requires 253.0589.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, SDS of cas: 35344-95-7

To a stirred solution of lH-pyrazole-4-carbaldehyde (S2-1) (200 mg, 2.08 mmol) in DMF (2 rnL) was added 2-iodopropane (707.66 mg, 4.16 mmol, 416.27 uL) and Cesium carbonate (1.36 g, 4.16 mmol) at ambient temperature. The resulting mixture was heated at 80C for 16 hours. It was then cooled to room temperature, diluted with ice cold w’ater and extracted with ethyl acetate. The combined extract was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. The reaction mixture was purified by flash chromatography (eluting with 30% ethyl acetate-hexane) to afford l-isopropylpyrazoJe-4-carbaldehyde (S2-2) (200 mg, 1.45 mmol, 69.54% yield) as brown liquid. LCMS: ES+ 139.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.