Category: 2075-46-9

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, belongs to pyrazoles-derivatives compound. In a document, author is Abdelrahman, E. F., introduce the new discover, Category: pyrazoles-derivatives.

Synthesis of Pyrano, Pyrido, Oxazino, and Spiro Pyrazole Derivatives and Their Antimicrobial Activity

Condensation of 5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one with 4-hydroxybenzaldhyde in alcoholic sodium hydroxide yielded 4-(4-hydroxybenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and treatment of the latter with acetylacetone, hydrazine hydrate, ethyl cyanoacetate, and ethyl acetoacetate gave pyranopyrazole, pyrazolopyrazole, and pyrazolopyridine derivatives. 5-Methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one was reacted with 2,4-dichlorobenzoyl isothiocyanate, thiosemicarbazide, and hydrazine hydrate to afford pyrazolooxazine, pyrazolopyrazole, and spiro[pyrazole-3,3 ‘-pyrazolo[3,4-c]pyrazole] derivatives. Some of the newly synthesized compounds showed high antimicrobial activity against three microbial strains (S. aureus, E. coli, C. albicans).

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2075-46-9 is helpful to your research. Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Application of 2075-46-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, belongs to pyrazoles-derivatives compound. In a article, author is Akhtar, Wasim, introduce new discover of the category.

Design and synthesis of pyrazole-pyrazoline hybrids as cancer-associated selective COX-2 inhibitors

In continuation of our previous work on cancer and inflammation, 15 novel pyrazole-pyrazoline hybrids (WSPP1-15) were synthesized and fully characterized. The formation of the pyrazoline ring was confirmed by the appearance of three doublets of doublets in(1)H nuclear magnetic resonance spectra exhibiting an AMX pattern for three protons (H-A, H-M, and H-X) of the pyrazoline ring. All the synthesized compounds were screened for their in vitro anticancer activity against five cell lines, that is, MCF-7, A549, SiHa, COLO205, and HepG2 cells, using the MTT growth inhibition assay. 5-Fluorouracil was taken as the positive control in the study. It was observed that, among them,WSPP11was found to be active against A549, SiHa, COLO205, and HepG2 cells, with IC(50)values of 4.94, 4.54, 4.86, and 2.09 mu M. All the derivatives were also evaluated for their cytotoxicity against HaCaT cells.WSPP11was also found to be nontoxic against normal cells (cell line HaCaT), with an IC(50)value of more than 50 mu M. The derivatives were also evaluated for their in vitro anti-inflammatory activity by the protein (egg albumin) denaturation assay and the red blood cell membrane stabilizing assay, using diclofenac sodium and celecoxib as standard. Compounds that showed significant anticancer and anti-inflammatory activities were further studied for COX-2 inhibition. The manifestation of a higher COX-2 selectivity index ofWSPP11as compared with other derivatives and an in vitro anticancer activity against four cell lines further established that compounds that were more selective toward COX-2 also exhibited a better spectrum of activity against various cancer cell lines.

Application of 2075-46-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 2075-46-9 is helpful to your research.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 2075-46-9, Name is 4-Nitro-1H-pyrazole, formurla is C3H3N3O2. In a document, author is Jacimovic, Zeljko K., introducing its new discovery. Application In Synthesis of 4-Nitro-1H-pyrazole.

Crystal structure of ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, C7H7F3N2O2

C7H7F3N2O2, monoclinic, P2(1)/m (no. 11), a = 6.8088(8) angstrom, b = 6.7699(9) angstrom, c = 9.9351(12) angstrom, beta = 105.416(3)degrees, V = 441.48(9) angstrom(3), Z = 2, R-gt(F) = 0.0398, wR(ref)(F-2) = 0.1192, T = 200(2) K.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, belongs to pyrazoles-derivatives compound. In a document, author is Taydakov, Ilya, V, introduce the new discover, Recommanded Product: 2075-46-9.

Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group

Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH3) reduction of a nitrile bearing a CF3 group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2075-46-9 is helpful to your research. Recommanded Product: 2075-46-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 2075-46-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2075-46-9, Name is 4-Nitro-1H-pyrazole, SMILES is C1=N[NH]C=C1[N+]([O-])=O, belongs to pyrazoles-derivatives compound. In a article, author is Flores, Erick, introduce new discover of the category.

Design, Synthesis and Biological Evaluation of Ferrocenyl Thiazole and Thiazolo[5,4-d]thiazole Catechols as Inhibitors of 5-hLOX and as Antibacterials against Staphylococcus aureus. Structural Relationship and Computational Studies

In the search for new human 5-lipoxygenase (5-hLOX) inhibitors that could be used for the treatment of a variety of inflammation-related diseases, three new ferrocenyl complexes derived from 2,4-thiazole and thiazolo[5,4-d]thiazole ((eta(5)-C5H4-2,4-thiazol-3,4-dihydroxyphenyl)Fe(eta(5)-C5H5) (3), (eta(5)-C5H4-2,4-thiazol-phenyl)Fe(eta(5)-C5H5) (4), and (eta(5)-C5H4-thiazolo[5,4-d]thiazole-3,4-dihydroxybenzene)Fe(eta(5)-C5H5) (5)) were synthesized and evaluated. A cooperative effect among the ferrocenyl, thiazole, and catechol fragments was evidenced and corroborated on evaluating the activity of the ferrocenyl (1) and catechol (2) precursors and additionally the organic derivative 6, similar to the NDGA structure. The thiazole derivative 3 was the best 5-hLOX inhibitor (85.8% inhibition, IC50 = 0.9 +/- 0.7 mu M for 5-hLOX and 22 +/- 1.1 mu M in human cells), followed by complex 4 (74.6% inhibition, IC50 = 5.4 +/- 1.7 mu M), which presents low cytotoxicity (>250 mu M), associated with the absence of OH groups (decrease in reactive oxygen species generation). Molecular dynamic and docking studies of 3 and 4 showed that the ferrocenyl fragment is oriented to the active iron(III) site present in 5-hLOX; kinetics and FRAP assays together with electrochemical analysis suggest a redox mechanism mediated by water (Fe(III) from enzyme/Fe(II) from complex) accompanied by the blocking of the substrate approach, being consistent with competitive inhibition. The ferrocenyl, together with the thiazole and catechol fragments, drastically improves the antibacterial activity (percentage of bacterial growth inhibition of 85.5% and a MIC value of 25 mu g/mL for 3), and an ROS assay suggests another mechanism for the antibacterial activity for Staphylococcus aureus.

Electric Literature of 2075-46-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2075-46-9.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

In an article, author is Milani, Jorge L. S., once mentioned the application of 2075-46-9, Recommanded Product: 2075-46-9, Name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, molecular weight is 113.08, MDL number is MFCD00159626, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category.

Chromium Complexes Supported by Phenyl Ether-Pyrazolyl [N,O] Ligands as Catalysts for the Oligo- and Polymerization of Ethylene

A new series of Cr (III) complexes [Cr{1-(3-phenoxypropyl)-1H-pyrazole}Cl-3](2)(Cr1),[Cr{1-(3-phenoxypropyl)-3,5-dimethyl-1H-pyrazole}Cl-3](2)(Cr2), and [Cr{1-(3-phenoxypropyl)-3-phenyl-1H-pyrazole}Cl-3](2)(Cr3)have been synthesized and characterized by elemental analysis, high-resolution mass spectrometry (HRMS) and IR spectroscopy. Upon activation with methylaluminoxane (MAO), chromium precatalystsCr2andCr3showed moderate activity in ethylene oligomerization [TOF = 17,900-29,200 mol (ethylene).mol (Cr)(-1).h(-1)at 80 degrees C] with Schultz-Flory distribution of oligomers (K= 0.54-0.66) and production of polymer varying from 2.8 to 6.7 wt.%. On the other hand, under identical oligomerization conditions,Cr1/MAO behaved as a polymerization catalyst generating predominantly polyethylene (63.7 wt%). The amount of 1-butene is the largest component in the liquid fraction suggesting that these precatalysts operate via a Cossee-Arlman mechanism. The catalytic activities, selectivity and product distribution are quite sensitive to the R-group at the 3- and 5-position of the pyrazolyl ring. Based on the electronic and steric effects of R- substituents, it is possible to stablish a trend of activity:Cr2(Pz(Me2)) >Cr3(Pz(Ph)) >Cr1(Pz). Moreover, the effect of oligomerization parameters (cocatalyst, temperature, [Al]/[Cr] molar ratio, time) on the activity and on the product distribution were examined.

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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 2075-46-9,Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Nitro-1H-pyrazole 12 (10.0 g, 88.4 mmol) was taken in CH3CN (100 mL) in a 250 mL round bottom flask under N2. To it were sequentially added iodomethane (18.8 g, 132.0 mmol) and K2C03 (30.5 g, 221.0 mmol). The reaction mixture was heated at 100C for 1 6h. The reaction mixture was then poured into ice water (100 g) and extracted with EtOAc (3 x 100 mL). The combined organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude was further washed with n-pentane to afford 15 as a light yellow solid (10.8 g, 96% yield). ?H NMR (400 MHz, CDC13): 88.11 (s, 1H), 8.05 (s, 1H), 3.96 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole, its application will become more common.

Application of 2075-46-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2075-46-9, name is 4-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-nitro-l/f-pyrazole (1.13 g, 10 mmol), Pd/C (10%, 57 mg) in ethanol (20 mL) was hydrogenated at 20-30 psi on a parr apparatu overnight. The reaction mixture was filtered through celite, washed with ethanol (10 mL). The filtrate was concentrated to get desired compound 0113-42 (404 mg, 49%) as a brown solid. LC-MS: 84 [M+l]+; 1H-NMR (400 MHz, DMSO-d6) delta 3.11 (br s, 2H), 6.99 (s, 2H), 11.92 (s, IH).

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2075-46-9, name is 4-Nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Nitro-1H-pyrazole

2-Bromoethanol (1.9 g, 15.57 mmol) and potassium carbonate (2.9 g, 21.12 mmol) were added to a solution of 4-nitropyrazole (1.6 g, 14.16 mmol) in acetonitrile (20 mL) in sequence, the mixture was heated to 60 C. and stirred for 16 hours. After cooled to room temperature, the mixture was filtrated, the filtrate was concentrated under reduced pressure to give compound 51-b (1.1 g, yield: 49.5%), which was used directly for the next step without purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 2075-46-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2075-46-9, name is 4-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 119 This example illustrates the preparation of Compound 108 namely, 3-pyridinecarboxylic acid, 5-[(4-amino-1H-pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester. A solution of 4-nitropyrazole (22.62 g, 200 mmol) in THF (100 mL) was cooled to 0 C., then sodium bis(trimethylsilyl)amide (204.3 mmol) in THF solution was added dropwise. A solution of Compound 84 (70.75 g, 200 mmol) in THF (100 mL) was then added dropwise at 0 C., then the pot was stirred at 25 C. for 30 minutes. The reaction mixture was then poured into 5% hydrochloric acid and extracted with dichloromethane. The organic layer was dried with MgSO4 and the solvent removed by rotary evaporation. The residue was purified by silica gel chromatography (5% ethyl acetate: hexane) to give 70.14 g (82%) of the pyrazole amide (Compound 101).

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.