Category: 25222-43-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25222-43-9 as follows. COA of Formula: C4H6N2O

General procedure: To a solution of compound 6 (131 mg, 0.50 mmol) in DMF (2 mL) was added pyrazole (51 mg, 0.75 mmol), K2CO3 (138 mg, 1.00 mmol). The mixture was heated at 100 °C for 1 h. Reaction mixture was cooled, ice cold water (30 mL) was added and then extracted with EtOAc twice (30 mL × 2) and the combined organic layers were washed by saturated brine (30 mL). Then the organic layers were dried over Na2SO4, filtered and evaporated to afford the crude product used without further purification, To a solution of CF3COOH (1 mL) in CH2Cl2 (4 mL) was added the remaining solid (92 mg, 0.30 mmol). The mixture was at room temperature for 3 h, and then it was concentrated under reduced pressure to afford the crude product 19 used without further purification. To a solution of the product (99 mg, 0.30 mmol) in DMF (8 mL) was added 3-[(R)-1-(4-fluorophenyl)ethylaminocarbonyl]-5-[methyl (methylsulfonyl)amino]benzoic acid (106 mg, 0.27 mmol), EDCI (52 mg, 0.27 mmol), HOBt (37 mg, 0.27 mmol), DIPEA (99 muL, 0.60 mmol) was added and the mixture was allowed to react overnight at room temperature. Then the resulting mixture was diluted by 50 mL EtOAc and washed with dilute HCl aqueous solution (30 mL), saturated aqueous NaHCO3 (30 mL) and saturated brine (30 mL) sequentially. The organic layers were dried over Na2SO4 and evaporated to give the residue, which was purified by silica gel chromatography to afford 20 (149 mg, 91.3 percent).

According to the analysis of related databases, 25222-43-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Li, Jia; Zou, Yiquan; Xu, Lei; Chen, Wuyan; Zhu, Yiping; Chen, Tiantian; Fu, Yan; Li, Li; Ma, Lanping; Xiong, Bing; Wang, Xin; Li, Jian; He, Jianhua; Zhang, Haiyan; Xu, Yechun; Shen, Jingkang; European Journal of Medicinal Chemistry; vol. 68; (2013); p. 270 – 283;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25222-43-9, Safety of (1H-Pyrazol-4-yl)methanol

Step 1: 4-(tert-Butyl-dimethyl-silanyloxymethyl)-1H-pyrazole (1H-Pyrazol-4-yl)-methanol (368 mg, [CAS Reg. No. 25222-43-9]) was dissolved in DMF (15 mL) and cooled to 0° C. To this solution was added triethylamine (455 mg), 4-dimethylaminopyridine (46 mg) and tert-butyldimethylchlorsilane (678 mg). Stirring was continued for 2 hours at r.t. The reaction mixture was poured into ice and extracted with chloroform. The combined organic layers were washed with brine, dried over Na2SO4, filtered and the solvent was evaporated. The residue was purified by flash chromatography (silica gel, heptane:ethyl acetate=100:0 to 0:100, then ethylacetate_methanol=95:5) to give the title compound as a yellow oil (348 mg, 42percent). MS (m/e)=213.3 [MH+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Pyrazol-4-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249139; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25222-43-9, SDS of cas: 25222-43-9

General procedure: Add acid chloride (2mmol) dropwise to (1H-pyrazol-4-yl) methanol or(1H-3,5-dimethylpyrazol-4-yl) methanol (1 mmol),4-Dimethylaminopyridine (0.2mmol) and triethylamine (2.5mmol) were dissolved in a solution of dichloromethane (30mL), and the reaction was stirred at room temperature for 12 hours, and then a saturated sodium bicarbonate solution was slowly added with sufficient stirring. Until the reaction no longer produces gas,The layers were separated, and the organic phase was washed twice with saturated sodium bicarbonate solution (20 mL each time) and once with water (20 mL). The organic phase was dried over anhydrous sodium sulfate and the solvent was removed by rotary evaporation. The residue was purified on a silica gel column of 100-200 mesh, and ethyl acetate / petroleum ether (60-90 C) (1: 5, volume ratio) was used as eluent. After removing the solvent by rotary evaporation, a pyrazole methoxide derivative having the general chemical structure I is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nankai University; Tang Liangfu; Xu Yue; Yang Jiali; Xia Dongqi; (10 pag.)CN110386899; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (1H-Pyrazol-4-yl)methanol

(lH-Pyrazol-4-yl)-methanol (0.55 g, 5.61 mmol) and imidazole (0.953 g, 14.00 mmol) are placed in an oven-dried flask under an atmosphere of argon. Dry DMF (2.2 mL) is added followed by tert-butyldiphenylsilyl chloride (1.85 g, 6.73 mmol). The reaction mixture is stirred at room temperature. The reaction is shown to be complete by TLC after 18 hours. The reaction mixture is partitioned between dichloromethane (50 mL) and water (50 mL). The organic layer is washed with water (20 mL) and brine (20 mL), dried over MgSO 4, filtered and the solvent is removed in vacuo. The title compound is obtained after purification by flash column chromatography (silica, ethyl acetate / isohexane 1:8). 1H nmr (CDCU 400 MHz); 7.70(m, 4H), 7.50(m, 2H), 7.40(m, 6H), 4.75(s, 2H), 1.10(s, 9H).

The synthetic route of (1H-Pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., 25222-43-9

General procedure: To a mixture of 3,6-dichloropyridazine (3.73 g, 25 mmol), 4(5)-Hydroxymethylimidazole (1.96 g, 20 mmol), and Cs2CO3 (8.14 g, 25 mmol) was added acetonitrile (80 mL). The mixture was refluxed for 3 h and was poured into H2O (200 mL). 1N HCl(aq) was added slowly until the pH is ca. 7-8. Then the aqueous layer was extracted with EtOAc (150 mL) and then CH2Cl2 (100 mL x 5). The combined organic layer was dried (Na2SO4) and filtered. After removal of solvent, the product was triturated with 10percent CH2Cl2/Et2O (30 mL x 3) to give 1.74 g of product. The filtrate was concentrated and was purified by column using 60-70-80percent EtOAc/(CH2Cl2/hexane=1/1) as the eluent to give 629 mg of prouct. Total 2.36g of D (53percent) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below., 25222-43-9

6-(2,2-Diphenyl-ethylamino)-9-((lR,4S)-4-ethoxycarbonyloxy-cyclopent-2-enyl)-9H-purine-2- carboxylic acid methyl ester (4.91 g, 9.3 mmol), (lH-Pyrazol-4-yl)-methanol (1.0 g, 10.2 mmol) and PhyP (0.73 g, 2.8 mmol) are dissolved in dry, deoxygenated tetrahydrofuran under EPO argon. Pd2(dba)3 (0.85 g, 0.93 mmol) is added to the reaction mixture. The reaction mixture is heated at 45¡ã C for 1 hour. The solvent is removed in vacuo. The title material is obtained by flash column chromatography (silica, eluent 0percent MeOH to 3percent MeOH in DCM) (MH+ 536.42).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

25222-43-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, A new synthetic method of this compound is introduced below.

(11H-Pyrazol-4-yl) methanol was Boc-protected by reaction with Boc-anhydride (1 .2 eq) and triethylamine (2.5 eq) in DCM at 0 ¡ãC, with warming to ambient temperature. The alcohol of this Boc-protected amine was then converted to the mesylate by reaction with methanesulfonyl chloride (1 .5 eq) and triethylamine (2.5 eq) in DCM at 0 ¡ãC, with warming to ambient temperature for 2 h. N-[1 -(Fluoromethyl)cyclopropyl]-3-[(1 -methylpyrazol-4- yl)methyl]-2,4-dioxo-1 H-quinazoline-6-sulfonamide (100 mg, 0.260 mmol), the mesylate (79 mg, 0.286 mmol) and potassium carbonate (54 mg, 0.39 mmol) in DMF was conventionally heated to 70 ¡ãC for 4 h. After Boc-deprotection with HCI in dioxane, usual work-up afforded the desired product (14 mg, 0.029 mmol, 1 1 percent) as a white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

25222-43-9, A common compound: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

A mixture of (5S,7S)-2-bromo-7-fluoro-5-phenyl-6,7-dihydro-5H-pyrrolo[l,2-b] [l,2,4]triazole (300 mg, 1.06 mmol), copper(l) iodide (1064 mg, 10.63 mmol), (lSSj-N lS -dimethylcyclohexane-l- diamine (1210 mg, 8.51 mmol), cesium carbonate (1039 mg, 3.19 mmol) and (lH-pyrazol-4- yl)methanol (1064 mg, 10.63 mmol) in 1,4-dioxane (2.5 mL) was heated at 140 ¡ãC for 3h a sealed tube under microwave. After cooled, the mixture was diluted with water (30 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 100-200 mesh, 0 to 15percent MeOH in isopropyl acetate) to afford final product (169 mg, 53percent) as a white solid. LC-MS T = 0.92 min, m/z = 300.1 (M+H) +. LCMS (5 to 95percent acetonitrile in water + 0.1percent formic acid over 2 mins) retention time 0.92 min, ESI+ found [M+H] = 300.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.