Category: 3112-31-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3112-31-0

Example 4-15: Synthesis of 5-[(R)-1-(3”Chloro-biphenyl-4-ylmethyl)-2~ethoxycarbonyl- ethylcarbamoyO-1 H-pyrazole-3-carboxyUc acid; To a mixture of Intermediate 17-1 (130 mg, 0.367 mmol), 1H-pyrazole-3,5-dicarboxylic acid (74.5 mg, 0.477 mmol), EDCI (91 mg, 0.477 mmol) and HOBt (64.5 mg, 0.477 mmof) in DMF (3 ml) is added triethylamine (149 mg, 0.203 mmol) and the mixture is stirred at room temperature for 18 hours. Any insoluble material is removed by filtration and the filtrate is chromatographed by HPLC using a gradient of 10percent MeCN/water to 100percent MeCN (+0.1percent TFA). Lyophitization of the proper fractions gives the title compound; HPLC Retention time 1.31 minutes (condition C); MS 456.2 (M+1); 1H NMR (400 MHz, DMSO-d6) delta ppm 1.12 (t, J=7,07 Hz1 3H), 2.54-2.67 (m, 2H)1 2.84-2.97 (m, 2H), 4.02 (q. J=7.07 Hz, 2H), 4.54 (m, 1H)1 7.11 (s, broad, 1H), 7.32 (d, J=8.08 Hzt 2H), 7.39 (m, 1H), 7.46 (t, 1 H)1 7.62 (d, J=8.08 Hz, 3H)1 7.69 (s. 1H), 8.41 (s, broad, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3112-31-0.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives

The complex 2 was synthesized by modification of Xie et al method [17]. Complex 2 was prepared by carrying out the reaction of 1, 10-phenanthroline, CoCl2¡¤6H2O and 1H-pyrazole-3,5-dicarboxylic acid (in the presence of KOH) in 2:1:1M ratio. The product was isolated by evaporation of reaction mixture after the completion of reaction which was monitored on TLC. Single crystals suitable for X-ray crystallography were obtained at room temperature. [Co(phen)2L], 2: Yield: 76%, m.p.>300C; CCDC: 1817080, anal. Calc. for [C29H18CoN6O4] (%): C, 60.74; H, 3.16; N, 14.66; Found: C, 60.68; H, 3.23; N, 14.23. UV-vis (1¡Á10-4 M, DMSO, lambdamax nm): 261 (pi-pi*), 330 (n-pi*), 573 (d-d). FT-IR (KBr pallet, upsilonmax/cm-1):1689, 1647 nu(C=O), 1572 nu(C=N), 1519 nu(C=C), 594 nu(Co-N), 426 nu(Co-O).

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Reference of 3112-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of CdCl2 (0.1mmol, 18.3mg) and 4-aminopyrazole (4-Hampz, 0.2mmol, 16.2mg) in H2O (10mL) was heated in a 23mL Teflon-lined reactor at 120¡ãC for 24h. After being cooled to room temperature, pale yellow crystals of 1 were collected by filtration, washed with water, and dried in air (54percent yield based on Cd.)

The synthetic route of 1H-Pyrazole-3,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Related Products of 3112-31-0, A common heterocyclic compound, 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, molecular formula is C5H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4 was synthesized by mixing 0.0118g of Mn, 0.0164g of KMnO4, 0.0343g of YCl3¡¤6H2O, 0.0544g of H3dpc, and 6.8g of distilled water. The homogeneous mixture was sealed into an autoclave (40mL) and put in a preheated oven at 180¡ãC for 3days. The single crystal particles of 4 obtained mixed with other phases that cannot be well separated from each other. Efforts for synthesis pure 4 were unsuccessful due to the tendency to yielding 3.

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Reference of 3112-31-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

The deionized water (3 mL) was slowly dropped over the mixturesolution containing Cu(NO3)23H2O (0.2 mmol, 48 mg) andpyrazine (0.2 mmol, 16 mg) in water and DMF (4 mL, 1:1 v/v) in15 mL of glass vial. Then, the solution of pyrazole-3,5-dicarboxylicacid (0.2 mmol, 35 mg) in deionized water and ethanol (5 mL,1:1 v/v) was carefully layered over the mixture layer. Then, the vialwas sealed and allowed to stand undisturbed at room temperature. The blue crystals of 1 were obtained after 2 days. Yield: 16 mg(34percent) based on copper salt. Anal. Calcd for Cu3C14H20N6O15: C,23.92; H, 2.87; N, 11.95. Found: C, 24.40; H, 2.80; N, 11.73percent. FTIRpeaks (KBr, cm-1): 3367br (m(OH)), 1622s (mas(OCO)), 1609s (m(CN)), 1509m, 1423w, 1395m (ms(OCO)), 1341s, 1330s, 1297s,1157w, 1127w, 1100w, 1063w, 1028w, 1017w, 930w, 828w,797w. UV-vis (diffuse reflectance, cm-1): 14049.

The chemical industry reduces the impact on the environment during synthesis 1H-Pyrazole-3,5-dicarboxylic acid. I believe this compound will play a more active role in future production and life.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C5H4N2O4

A mixture of LaCl3¡¤7H2O (0.187g, 0.5mmol), H3pdc (0.175g, 1.0mmol), NaOH (0.041g, 1.0mmol) and H2O (5mL) was placed in a 23mL Teflon-lined Parr acid digestion bomb and heated for two days at 180¡ãC under autogenous pressure. Upon cooling to room temperature, solution was separated from the solid phase, and after filtration precipitate washed with water and acetone, respectively. The product was dried at ambient temperature. The colorless crystals of 1 were obtained with high yield and the synthesized single crystals suited for X-ray diffraction analysis. Yield ca. 86percent (based on La). Initial pH was 2.50; final pH was 1.88. Crystalline 1 is insoluble in water and common solvents and stable in air. Anal. Calc. for C15H15La2N6O18: C, 21.29; H, 1.78; N, 9.93. Found: C, 21.18; H, 2.18; N, 9.67percent. IR data (KBr pellet, cm?1): 3410(m), 3160(m), 1593(vs), 1458(m), 1352(vs), 1311(vs), 1017(s), 837(w), 783(s), 629(w).

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Adding some certain compound to certain chemical reactions, such as: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3112-31-0. 3112-31-0

A procedure identical with that of 1 was followed for the preparation of 4, except that CuSO4¡¤5H2O was replaced by Cu(NO3)2¡¤3H2O (0.121g, 0.5mmol), purple microcrystals were obtained (yield: 74percent, based on Cu(NO3)2¡¤3H2O). Elem. Anal. Calcd for C15H16CuDy2N6O18: C 18.51, H 1.68, N 8.73. Found: C 18.62, H 1.71, N 8.64. IR (KBr pellet cm?1): 3420(s), 1630(s), 1592(s), 1509(m), 1392(m), 1326(s), 1271(m), 1062(w), 1015(w), 853(w), 782(w).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1H-Pyrazole-3,5-dicarboxylic acid.

A common compound: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 3112-31-0

A.5-[(R)-2-Biphenyl-4-yl-1-(1-carboxy-cyclopropylmethyl)-ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid (R7=H)3,5-Pyrazoledicarboxylic acid (35.2 mg, 226 mumol, 1.0 eq.), DIPEA (126 muL) and HATU (85.9 mg, 226 mumol, 1.0 eq.) and DCM (5 mL) were combined and stirred for 5 minutes at room temperature. 1-((R)-2-Amino-3-biphenyl-4-yl-propyl)-cyclopropanecarboxylic acid (86.7 mg, 294 mumol, 2.3 eq,) and DIPEA (0.5 mL) in DCM (5 mL) was added, and the resulting mixture was stirred for 1 hour.The reaction was quenched with saturated aqueous NH4Cl and the product was extracted with DCM, dried and evaporated.The resulting product was combined with AcOH (1.5 mL) and purified with preparative HPLC to yield the title compound (21.4 mg; 93percent purity). MS m/z [M+H]+ calc’d for C24H23N3O5, 434.16; found 433.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3112-31-0, other downstream synthetic routes, hurry up and to see.