Category: 3112-31-0

Synthetic Route of 3112-31-0, These common heterocyclic compound, 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 To a solution of Compound 1 (60 g, 345 mmol) in methanol (600 mL), under nitrogen atmosphere, thionyl chloride (75 mL, 1034 mmol) was added at 0C, followed by heating at reflux for 4 hours. The reaction solution was concentrated in vacuo to yield crude product 2 (64.3 g). LC/MS (Method A): 0.93 min, [M+H]+ = 185.

Statistics shows that 1H-Pyrazole-3,5-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 3112-31-0.

Reference:
Patent; Shionogi&Co., Ltd.; EP2327704; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 3112-31-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3112-31-0 name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of pyrazole-3,5-dicarboxylic acid (75 g, 431 mmol) in 11 of anhydrous methanol was treated with anhydrous HCl gas. The HCl addition was continued for 30 min after which, the solution was allowed to cool to room temperature and allowed to stand for 16 h. The solution was then heated at reflux for 3 h then cooled and the solvent removed at reduced pressure. The resulting white solid was treated with 600 ml of saturated NaHCO3 and extracted into CH2 Cl2 (3*500 ml). The pooled extracts were dried (Na2 SO4), filtered and evaporated at reduced pressure. The resulting white solid was recrystallized from methanol with the addition of anhydrous ether to give dimethyl pyrazole-3,5-dicarboxylate (3-1a). 1 H NMR (CDCl3) delta 7.38 (s, 1H); 3.98 (s, 3H); 3.93 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-3,5-dicarboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Merck & Co., Inc.; US5821241; (1998); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 3112-31-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3112-31-0 as follows.

General procedure: Pyrazole-3,5-dicarboxylic acid (0.348 g, 2 mmol) and0.168 g piperazine (2 mmol) were dissolved in 20 cm3distilled water. The mixture was stirred for 1 h at room temperature. Then metal salts, 0.291 g nickel(II) nitratehexahydrate (1 mmol) for 1 and 0.169 g manganese(II)sulfate tetrahydrate (1 mmol) for 2 were added into the above-mentioned solution. The reaction mixture was refluxed for 3 h. It was then gradually cooled to room temperature and kept until crystals suitable for X-ray diffraction were obtained.

According to the analysis of related databases, 3112-31-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sharif, Mahboubeh A.; Najafi, Gholam Reza; Monatshefte fur Chemie; vol. 147; 9; (2016); p. 1557 – 1563;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 3112-31-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3112-31-0 name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(A mixture of Dy2O3 (0.187g, 0.5mmol), CuSO4·5H2O (0.125g, 0.5mmol), H3PDC (0.174g, 1.0mmol) and H2O (10mL) was stirred in air for 1h, and then was sealed in a Parr Teflon-lined stainless-steel bomb and heated at 160°C for 3 d, cooled down to room temperature (r.t.) at 2°Ch?1 before the furnace was switched off. The resulting purple, columnar crystals of 1 (ca. 0.30mm in length and 0.20nm in diameter) were collected after washing with water (yield: 76percent, based on CuSO4·5H2O). Elem. Anal. Calcd for C10H16CuDy2N4O19S: C 13.10, H 1.79, N 6.11. Found: C 13.13, H 1.82, N 6.09. IR (KBr pellet cm?1): 3445(s), 1621(s), 1598(s), 1509(m), 1393(m), 1328(s), 1276(m), 1138(w), 1063(w), 1014(w), 853(w), 782(w).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-3,5-dicarboxylic acid, and friends who are interested can also refer to it.

Reference:
Article; Wang, Min; He, Liang; Lin, Qipu; Journal of Solid State Chemistry; vol. 265; (2018); p. 29 – 35;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1H-Pyrazole-3,5-dicarboxylic acid

Example 20: 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid methyl ester(i) 1H-Pyrazole-3,5-dicarboxylic acid dimethyl ester To 12 g of 1H-Pyrazole-3,5-dicarboxylic acid 100 ml HCl in methanol (8M) were added at RT and stirred for 48h. Then the solvents were removed under reduced pressure and the residue codestilled with toluene (2X50 ml). Yield: 14g.

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3112-31-0, Product Details of 3112-31-0

(2R,4R)-4-Amino-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester (HCl salt; 108 mg, 286 mummol, 1.0 eq.), 3,5-pyrazoledicarboxylic acid (66.9 mg, 429 mumol, 1.5 eq.), and HATU (160 mg, 430 mumol, 1.5 eq.) were combined in DMF (5 mL), and the resulting mixture was stirred for 2 minutes. DIPEA (150 muL) was added and the mixture was stirred for 1 hour. The mixture was dried under vacuum, and the product was purified using reverse phase chromatography to yield the title compound as a TFA salt (60 mg; purity 98percent). MS m/z [M+H]+ calc’d for C26H29N3O6, 480.21. found 480.4).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H4N2O4

A. 5-[(R)-2-Biphenyl-4-yl-1-(1-carboxy-cyclopropylmethyl)-ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid (R7 = H) 3,5-Pyrazoledicarboxylic acid (35.2 mg, 226 mumol, 1.0 eq.), DIPEA (126 muL) and HATU (85.9 mg, 226 mumol, 1.0 eq.) and DCM (5 mL) were combined and stirred for 5 minutes at room temperature. 1-((R)-2-Amino-3-biphenyl-4-yl-propyl)-cyclopropanecarboxylic acid (86.7 mg, 294 mumol, 2.3 eq,) and DIPEA (0.5 mL) in DCM (5 mL) was added, and the resulting mixture was stirred for 1 hour. The reaction was quenched with saturated aqueous NH4Cl and the product was extracted with DCM, dried and evaporated. The resulting product was combined with AcOH (1.5 mL) and purified with preparative HPLC to yield the title compound (21.4 mg; 93percent purity). MS m/z [M+H]+ calc’d for C24H23N3O5, 434.16; found 433.5.

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Related Products of 3112-31-0, A common heterocyclic compound, 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, molecular formula is C5H4N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a typical synthesis, 0.17mmol (0.0300g) of H3dpc, 0.36mmol (0.0586g) of MnCl2 2H2O, 0.26mmol (0.0403g) of 4,4?-bpy and 10mL of distilled water were mixed. The reaction mixture was stirred until a homogeneous gel was formed (pH 4), sealed in a PTFE-lined stainless steel autoclave with an internal volume of 40mL and heated at 150¡ãC for 3days under autogenous pressure. After cooling to room temperature, the resulting block single crystal particles that was confirmed to be compound 3 by XRD were filtered off, washed with distilled water (3*50mL), and dried in an ambient condition. Yield 0.031g, 73percent based on H3dpc. The mother liquor was allowed to stand still for evaporation. After one week, small amount single crystals were found grown up on the wall of beaker. These crystal particles were collected and air dried at room temperature, single crystal X-ray diffraction data revealed that these particles were phase 1. Yield 0.010g, 9.4percent based on H3dpc.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 3112-31-0

(2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester (1.0 g, 3.9 mmol, 1.0 eq.), HATU (1.5 g, 3.9 mmol, 1.0 eq.), and 3,5-pyrazoledicarboxylic acid (0.6 g, 3.9 mmol, 1.0 eq.) were combined in DMF (5 mL) and stirred for 2 minutes. DIPEA (3.0 eq.) was added and the mixture was stirred for 1 hour then vacuumed to dryness. EtOAc (200 mL) was added and the mixture was washed with 1N HCl (100 mL), NaHCO3 (100 mL), and saturated aqueous NaCl (100 mL). The organic layer was retained and dried over anhydrous MgSO4 for 10 minutes prior to filtration and evacuation to dryness. The product was then treated with 1.25M HCl in EtOH (20 mL), heated to 100¡ã C. overnight, then vacuumed to dryness. The product was then purified by flash chromatography (0-75percent EtOAc/hexanes) to yield the title compound (1.1 g).

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

A solution of the pyrazole 3,5-dicarboxylicacid (1.60 mmol, 0.25 g) in thionyl chloride (4 mL) was heated underreflux for 2 h. Excess solvent was then distilled off and the crude 23dried under vacuum. A solution of the crude pyrazole diacylchloride 23,triethylamine (4.8 mmol, 0.67 mL) and DMAP (0.32 mmol, 0.039 g) inanhydrous dichloromethane (13 mL) was cooled in an ice bath and theamine 24 (3.28 mmol, 0.782 g) was added slowly as a solution indichloromethane (3 mL). The reaction mixture was allowed to gradually warm up to room temperatureand stirred overnight. The mixture was then washed with 10percent hydrochloric acid and water, and theorganic layer separated. The aqueous layer was further extracted two more times with dichloromethane.Combined organics were dried with anhydrous sodium sulfate, filtered, concentrated and purified by flashcolumn chromatography to furnish the title compound a white solid in 85percent yield.

According to the analysis of related databases, 3112-31-0, the application of this compound in the production field has become more and more popular.