Category: 3524-32-1

Synthetic Route of 3524-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 0.5M solution of NaOH in water (100mL) containing aminopyrazole 1 (3mmol, 0.29g) was placed into a glass cell with a cylindrical Ni anode (S=48cm2, activated before the synthesis according to the literature procedure23) and a Ti cathode (S=20cm2). Electrolysis was carried out at a current of 290mA. After passing 2F of electricity per mol of the substrate (Q=579C), the electrolysis was stopped. The reaction mixture was stirred for 0.5h and concentrated HCl was added until the solution was pH ?3. The mixture was then extracted with CHCl3 (3×40mL). The extracts were combined, dried over Na2SO4 and concentrated in vacuo. Column chromatography on silica with light petroleum ether:ethyl acetate (10:1) gave the pure azopyrazole 1a (82%, 0.47g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1,3-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lyalin, Boris V.; Sigacheva, Vera L.; Kokorekin, Vladimir A.; Petrosyan, Vladimir A.; Tetrahedron Letters; vol. 59; 28; (2018); p. 2741 – 2744;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 5-Amino-1,3-dimethylpyrazole

To a solution of 5-amino-1,3-dimethylpyrazole (300 mg, 2.70 mmol) in dichloromethane (3 mL) was added at ambient temperature under a nitrogen atmosphere N-BOC-(4′-chlorophenyl)glycine (771 mg, 2.70 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (569 mg, 2.97 mmol), 1-hydroxybenzotriazole (36 mg, 0.27 mmol) and N,N-diisopropyl ethyl amine (693 mul, 4.05 mmol). The resulting reaction mixture was was stirred for 18 h at this temperature. The solution was diluted with ethyl acetate (20 mL) and washed with aqueous sodium carbonate (half saturated, 20 mL), water (20 mL) and brine (20 mL). The combined aqueous layers were extracted with ethyl acetate (20 mL) and the combined organic layers were dried over sodium sulfate. Concentration and purification by chromatography (SiO2, heptane:ethyl acetate=80:20 to 0:100) afforded the title compound (656 mg, 64%) as a colorless oil. MS m/e: 379.3 [M+H]+.

The synthetic route of 3524-32-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Knust, Henner; Nettekoven, Matthias; Pinard, Emmanuel; Roche, Olivier; Rogers-Evans, Mark; US2009/312314; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 3524-32-1

Step 1 An oven dried 100 mL round bottomed flask equipped with a stirring bar was cooled under nitrogen and charged with 1,3-dimethyl-1H pyrazol-5-amine (491.7 mg, 4.42 mmol) and 45 mL of anhydrous THF (0.1M). The THF solution was treated with solid LiHMDS (1.481 g, 8.84 mmol) and stirred at RT for 5 min after which yellow solids formed. C-2 (500 mg, 2.21 mmol) was added in one portion. The flask was equipped with a reflux condenser, and the reaction mixture heated to 80 C. The reaction was monitored by LCMS and was 90% complete after 2 h at 80 C. The reaction mixture was cooled to RT, and the THF removed on a rotary evaporator. The crude residue was partitioned between DCM and water. The DCM layer was washed with brine, dried (MgSO4) filtered and concentrated. The crude residue was absorbed onto Celite and purified by SiO2 chromatography eluting with an EtOAc/heptane gradient (50 to 100% EtOAc) to afford 328 mg (47%) of 6-bromo-N-(1,3dimethyl-1H pyrazol-5-yl)-isoquinolin-3-amine (82).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3524-32-1, its application will become more common.

Reference:
Patent; Genentech, Inc.; Array BioPharma Inc.; Blake, Jim; Chen, Huifen; Chicarelli, Mark; Gaudino, John; Gazzard, Lewis; Kintz, Sam; Mohr, Pete; Robarge, Kirk; Schwarz, Jacob; Zhou, Aihe; US2014/66453; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 3524-32-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 5-amino-3-methylpyrazole (1 mmol), isatin or acenaphthylene-1,2-dione (1 mmol), thioacid (1 mmol), and p-TSA (30 mol %) in CH3CN (5 mL) was stirred at 80 C for 12-24 h. After completion of the reaction confirmed by TLC (eluent acetone/petroleum ether, 1:2), the reaction mixture was cooled to room temperature. Then, the solvent was removed under vacuum. The solid was recrystallizated from CH3CN and ethanol to afford the pure 4 or 6 as a white or yellow powder.

The chemical industry reduces the impact on the environment during synthesis 5-Amino-1,3-dimethylpyrazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Chen, Hui; Shi, Daqing; Tetrahedron; vol. 67; 31; (2011); p. 5686 – 5692;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, A new synthetic method of this compound is introduced below., Formula: C5H9N3

General procedure: 3-methyl-1-phenyl-1H-pyrazol-5-amine (1 mmol, 173 mg) and acetophenone (1.5 mmol, 180 mg), CuI (10 mol %, 19 mg) and FeCl3.6H2O (10 mol %, 27 mg) were added in DMSO (2 mL) at 120C in a round-bottom flask equipped with a magnetic stirring bar and a reflux condenser. After completion of the reaction the organic mixture was extracted with ethyl acetate (3×50 mL) and then washed with brine solution. The organic fraction was dried with anhydrous sodium sulphate and concentrated in rotavapor under vacuum. The product was purified by column chromatography using silica gel (100-200 mesh, ethyl acetate/hexane as eluent).

The synthetic route of 3524-32-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rastogi, Gaurav K.; Saikia, B-Shriya; Pahari, Pallab; Deb, Mohit L.; Baruah, Pranjal K.; Tetrahedron Letters; vol. 60; 17; (2019); p. 1189 – 1192;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3524-32-1

General procedure: A solution of equimolar amounts (4.5 mmol) of 1,3-dimethyl-1H-pyrazol-5-amine 3 [18] and substituted phenylisocyanates 4a-g in THF (12 mL) was stirred at room temperature for 24 h. The solid residue was filtered, washed with 1 mL of ethyl acetate, and then crystallized from a suitable solvent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3524-32-1, its application will become more common.

Reference:
Article; Raimondi, Maria Valeria; Maggio, Benedetta; Raffa, Demetrio; Plescia, Fabiana; Cascioferro, Stella; Cancemi, Gabriella; Schillaci, Domenico; Cusimano, Maria Grazia; Vitale, Maria; Daidone, Giuseppe; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 64 – 71;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 3524-32-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3524-32-1 as follows.

General procedure: A stirred mixture of 1-substituted 5-aminopyrazole 2 (2.5 mmol), dichloro compound 1 (3.3 mmol), and acetonitrile (5 mL) was warmed gently to dissolve the starting materials and then cooled in an ice/water bath. Triethylamine (0.70 mL, 5 mmol) was added dropwise and the resulting mixture was stirred at room temperature or 50C until conversion was no longer observed by TLC. The reaction mixture was diluted slowly with water (20 mL) and extracted with dichloromethane. The crude product was chromatographed over silica gel and the product was recrystallised.

According to the analysis of related databases, 3524-32-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Norman, Rebecca E.; Perkins, Michael V.; Liepa, Andris J.; Francis, Craig L.; Australian Journal of Chemistry; vol. 68; 9; (2015); p. 1455 – 1466;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 3524-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Electrolysis was carried out usinga B5-49 direct current source, 0.2 m aqueous NaOH as the supportingelectrolyte, in a glass temperature-controlled (25 C) cell (V = 150 ml)with a NiO(OH) anode (S = 48 cm2) prepared by a reported procedure36and a Ti cathode (S = 20 cm2). The supporting electrolyte (100 ml) andamine 1a-e (0.003 mol) were placed into the cell and electrolysis wascarried out at a current of 290 mA. Once a 2 F per mole of the startingamine was passed (Q = 579 C), electrolysis was stopped. The reactionmixture was stirred for more 0.5 h in the absence of current and analyzedby TLC with light petroleum-ethyl acetate (1:1) as the eluent. ConcentratedHCl was then added to the reaction mixture to pH ~ 3 andthe mixture was extracted with CHCl3 (3×50 ml). The extracts werecombined, dried with anhydrous MgSO4 and concentrated in vacuo.Column chromatography on SiO2 with light petroleum-ethyl acetate(10:1) as the eluent gave azopyrazoles 2a-e which were identified usingthe reported characteristics.26,28 The aqueous solution that remainedafter extraction (see above) was concentrated in vacuo and NaOH wasadded with stirring (to pH ~ 10). The nonreacted starting amines 1a-ewere extracted with CHCl3 (3×30 ml) and identified by TLC and 1H NMR.

The synthetic route of 5-Amino-1,3-dimethylpyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lyalin, Boris V.; Sigacheva, Vera L.; Kokorekin, Vladimir A.; Petrosyan, Vladimir A.; Mendeleev Communications; vol. 25; 6; (2015); p. 479 – 481;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, A new synthetic method of this compound is introduced below., Product Details of 3524-32-1

General procedure: In a 50 mL single-mouth flask,Salicylaldehyde (1 mmol) was added in sequence,Ethyl cyanoacetate (1 mmol) and 3-methyl-1-phenyl-5-aminopyrazole (1 mmol),Triethylamine (0.1 mmol) and ethanol (8 mL),The reaction was stirred under reflux for 8 h.After the reaction is over,Cool to room temperature.Rotate the solvent under reduced pressure,Get a rough product,The crude product was recrystallized from 95% ethanol.5-amino-1-methyl-3-phenylcoumarin[4,3-d]pyrazolo[3,4-b]pyridine-6(3H)-one (Ia):Yield 63%

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Soochow University (Suzhou); Shi Daqing; Zhang Mengye; Xu Wentao; Wang Ning; Huang Zhibin; (17 pag.)CN108409748; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 3524-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 3-methyl-1-phenyl-1H-pyrazol-5-amine (1 mmol, 173 mg) and acetophenone (1.5 mmol, 180 mg), CuI (10 mol %, 19 mg) and FeCl3.6H2O (10 mol %, 27 mg) were added in DMSO (2 mL) at 120C in a round-bottom flask equipped with a magnetic stirring bar and a reflux condenser. After completion of the reaction the organic mixture was extracted with ethyl acetate (3×50 mL) and then washed with brine solution. The organic fraction was dried with anhydrous sodium sulphate and concentrated in rotavapor under vacuum. The product was purified by column chromatography using silica gel (100-200 mesh, ethyl acetate/hexane as eluent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1,3-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Rastogi, Gaurav K.; Saikia, B-Shriya; Pahari, Pallab; Deb, Mohit L.; Baruah, Pranjal K.; Tetrahedron Letters; vol. 60; 17; (2019); p. 1189 – 1192;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics