Category: 1203705-55-8

1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C3H4BrN3

A mixture of methyl 2-hydroxy-4-oxo-4-(pyridin-2-yl)but-2-enoate [1224740-13-9] (730 mg, 3.52 mmol) and 3-bromo-lH-pyrazol-5-amine [950739-21-6] (628 mg, 3.88 mmol) in MeOH (17 mL) was stirred under reflux for 18 h. The reaction mixture was cooled to rt and the precipitate was filtered off, rinsed with MeOH and dried. The residue (546 mg) was purified via achiral SFC (Stationary phase: Lux Cellulose-2 5 pm 250*30mm, mobile phase: 60% C02, 40% MeOH) to afford intermediate 1171 (147 mg, 13%) as a yellow solid.

The synthetic route of 1203705-55-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN SCIENCES IRELAND UNLIMITED COMPANY; LANCOIS, David Francis Alain; GUILLEMONT, Jerome Emile Georges; RABOISSON, Pierre Jean-Marie Bernard; ROYMANS, Dirk Andre Emmy; RIGAUX, Peter; MICHAUT, Antoine Benjamin; MERCEY, Guillaume Jean Maurice; (295 pag.)WO2019/106004; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1203705-55-8 as follows. Safety of 3-Bromo-1H-pyrazol-5-amine

1-(1,3-dimethyl-1H-pyrazol-4-yl)-4,4,4-trifluoro-3-hydroxybut-2-en-1-one (Preparation 5, 1.7 g) and 3-bromo-1H-pyrazol-5-amine (Preparation 6, 1.18 g) in Acetic acid (52.61 mL) was heated at 120 C. in a sealed tube overnight. The reaction solution was cooled to room temperature, and poured into ice water (500 mL) resulting in a white precipitate. The precipitate was filtered and washed with copious amounts of water. The precipitate was then collected and dried in vacuo to afford the title compound as a white powder (1.9 g, 73.1%). [0524] 1HNMR (400 MHz, DMSO-d6) delta: 2.47 (s, 3H), 3.79, (s, 3H), 6.95, (s, 1H), 7.73, (s, 1H), 8.67, (s, 1H).

According to the analysis of related databases, 1203705-55-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn; US2013/324547; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-1H-pyrazol-5-amine

A mixture of methyl 2-hydroxy-4-oxo-4-(pyridin-2-yl)but-2-enoate [1224740-13-9] (730 mg, 3.52 mmol) and 3-bromo-lH-pyrazol-5-amine [950739-21-6] (628 mg, 3.88 mmol) in MeOH (17 mL) was stirred under reflux for 18 h. The reaction mixture was cooled to rt and the precipitate was filtered off, rinsed with MeOH and dried. The residue (546 mg) was purified via achiral SFC (Stationary phase: Lux Cellulose-2 5 pm 250*30mm, mobile phase: 60% C02, 40% MeOH) to afford intermediate 1171 (147 mg, 13%) as a yellow solid.

The synthetic route of 1203705-55-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN SCIENCES IRELAND UNLIMITED COMPANY; LANCOIS, David Francis Alain; GUILLEMONT, Jerome Emile Georges; RABOISSON, Pierre Jean-Marie Bernard; ROYMANS, Dirk Andre Emmy; RIGAUX, Peter; MICHAUT, Antoine Benjamin; MERCEY, Guillaume Jean Maurice; (295 pag.)WO2019/106004; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C3H4BrN3

1.0 g of compound II was dissolved in 15 mL of acetic acid, and 0.61 g of 3-bromo-1H-pyrazole-5-amine was added to the above solution, heated under reflux, and monitored by thin layer chromatography. After the reaction was completed, the mixture was extracted with ethyl acetate-water. The ethyl acetate layer was dried over anhydrous sodium sulfate, and the solution was concentrated. Column chromatography of dichloromethane-methanol 100: 3 gave 1.25 g of compound III. Yield: 91.1%.

The synthetic route of 1203705-55-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southern Medical University; Chen Jianjun; Li Gang; Deng Xin; Ren Yichang; Li Ling; (23 pag.)CN110563732; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 1203705-55-8, These common heterocyclic compound, 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1H-Pyrazol-5-amine 1 (1 equiv.), 3-oxopropanenitrile 2 (1 equiv.), benzaldehyde 3 (1 equiv.), and Et3N (2 equiv.) were stirred in DMF (1 M) at 90 C for 16 h. The volatiles were removed under reduced pressure (or positive N2 (g) pressure). Sodium nitrite (3 equiv.) and acetic acid (134 equiv.) were added to the crude material, and the reaction mixture was stirred for 10 min. The volatiles were removed under reduced pressure (or positive N2 (g) pressure), and the crude reaction mixture was subjected to silica gel column chromatography with ethyl acetate in hexanes.

The synthetic route of 1203705-55-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Formula: C3H4BrN3

Methyl 2-(2-bromo-7-hydroxy-5-methylpyrazolo / ,5-aj ‘pyrimidin-6-y I) acetate.; To a solution of 3-bromo-lH-pyrazol-5-amine (0.2 g, 1.235 mmol) and dimethyl 2- acetylsuccinate (0.697 g, 3.70 mmol) in xylene (10 mL) was added -toluenesulfonic acid monohydrate (2 mg, 10.51 muiotaetaomicron). The reaction mixture was heated at reflux under a Dean-Stark trap for 8 h. The solid was filtered and washed with hexanes to afford the title compound (0.201 g, 54.2%). ? NMR (400 MHz, MeOD) delta ppm 2.37 (3 H, s), 3.65 (2 H, s), 3.71 (3 H, s), 6.20 (1 H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 1203705-55-8, The chemical industry reduces the impact on the environment during synthesis 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, I believe this compound will play a more active role in future production and life.

To a solution of 3-bromo-1H-pyrazol-5-amine (3.2 g, 20.0 mmol) in DMF (60 mL) were added Cs 2CO 3 (13.0 g, 40.0 mmol) and ethyl-3-ethoxyacrylate (8.6 g, 60.0 mmol), the reaction mixture was stirred at 125 C for about 2 h. The reaction mixture was cooled to ambient temperature, poured into H 2O (200 mL), acidified by 1N HCl acid solution, extracted with EA (100 mL 3). The combined organic layers were washed with H 2O (100 mL), concentrated and purified by chromatography on silica gel (eluent: DCM/MeOH = 10/1) to afford the desired compound as a yellow solid (2.0 g). MS (ESI, m/e) [M+1] + 213.9, 214.9.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Application of 1203705-55-8, The chemical industry reduces the impact on the environment during synthesis 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, I believe this compound will play a more active role in future production and life.

To a solution of 3-bromo-1H-pyrazol-5-amine (3.2 g, 20.0 mmol) in DMF (60 mL) were added Cs 2CO 3 (13.0 g, 40.0 mmol) and ethyl-3-ethoxyacrylate (8.6 g, 60.0 mmol), the reaction mixture was stirred at 125 C for about 2 h. The reaction mixture was cooled to ambient temperature, poured into H 2O (200 mL), acidified by 1N HCl acid solution, extracted with EA (100 mL 3). The combined organic layers were washed with H 2O (100 mL), concentrated and purified by chromatography on silica gel (eluent: DCM/MeOH = 10/1) to afford the desired compound as a yellow solid (2.0 g). MS (ESI, m/e) [M+1] + 213.9, 214.9.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1203705-55-8, These common heterocyclic compound, 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 2-(2-bromo-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate To a solution of 3-bromo-1H-pyrazol-5-amine (0.2 g, 1.235 mmol) and dimethyl 2-acetylsuccinate (0.697 g, 3.70 mmol) in xylene (10 mL) was added p-toluenesulfonic acid monohydrate (2 mg, 10.51 mumol). The reaction mixture was heated at reflux under a Dean-Stark trap for 8 h. The solid was filtered and washed with hexanes to afford the title compound (0.201 g, 54.2%). 1H NMR (400 MHz, MeOD) delta 2.37 (3H, s), 3.65 (2H, s), 3.71 (3H, s), 6.20 (1H, s).

Statistics shows that 3-Bromo-1H-pyrazol-5-amine is playing an increasingly important role. we look forward to future research findings about 1203705-55-8.

A common heterocyclic compound, 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, molecular formula is C3H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1203705-55-8.

Methyl 2-(2-bromo-7-hydroxy-5-methylpyrazolo / ,5-aj ‘pyrimidin-6-y I) acetate.; To a solution of 3-bromo-lH-pyrazol-5-amine (0.2 g, 1.235 mmol) and dimethyl 2- acetylsuccinate (0.697 g, 3.70 mmol) in xylene (10 mL) was added -toluenesulfonic acid monohydrate (2 mg, 10.51 muiotaetaomicron). The reaction mixture was heated at reflux under a Dean-Stark trap for 8 h. The solid was filtered and washed with hexanes to afford the title compound (0.201 g, 54.2%). ? NMR (400 MHz, MeOD) delta ppm 2.37 (3 H, s), 3.65 (2 H, s), 3.71 (3 H, s), 6.20 (1 H, s).

The synthetic route of 3-Bromo-1H-pyrazol-5-amine has been constantly updated, and we look forward to future research findings.