Category: 52222-73-8

Reference of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred suspension of 4-(trifluoromethyl)-1H-pyrazole (0.4 g, 2.93 mmol) in dry DMF (8 mL), Cs2CO3 (1.91 g, 5.87mmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-1-carboxylate (obtained as described in Step 1 of Intermediate 10, 1.23 g, 5.87 mmol) were added at 0 C. The reaction mixture was stirred at 80 C overnight, and the reaction mixture was diluted with water (10 mL). The product was extracted with EtOAc (2 x 10 mL). The combined organic layer was dried over anhydrous Na2S04 and concentrated under vacuum. The crude product was purified by flash chromatography on silica gel (230-400 mesh) to afford the title compound. Yield: 73% (0.69 g, pale brown solid). 1H NMR (400 MHz, DMSO-d6): delta 8.71 (s, 1 H), 7.90 (s, 1 H), 4.44 (q, J = 7.6 Hz, 1 H), 4.04-4.06 (m, 2H), 3.10-2.69 (m, 2H), 2.02-2.08 (d, 2H), 1.84-1.75 (m, 2H), 1.42 (s, 9H). LCMS: (Method A) 264.2 (M-56), Rt. 4.82 min, 91.18% (Max).

The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.

52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C4H3F3N2

55 mg of 2-[3-(ethylsulphonyl)-6-fluoropyridin-2-yl]-1-methyl-5-(trifluoromethyl)-1H-benzimidazole (0.14 mmol) were dissolved in 2 ml of acetonitrile. 29 mg (0.21 mmol) of 4-(trifluoromethyl)-1H-pyrazole and 59 mg (0.42 mmol) of potassium carbonate were added and stirred for 3 h at room temperature. The mixture was filtered, concentrated and purified by column chromatography with a cyclohexane/ethyl acetate gradient as mobile phase. log P (neutral): 4.16; MH+: 504; 1H-NMR (400 MHz, D6-DMSO) delta ppm: 9.38 (s, 1H), 8.712 (d, 1H), 8.46 (s, 1H), 8.42 (d, 1H), 8.16 (s, 1H), 7.98 (d, 1H), 7.70 (dd, 1H), 3.906 (q, 2H), 3.90 (s, 3H), 1.24 (t, 3H).

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 52222-73-8

A mixture of compound 26 (200 mg, 0.342 mmol), 4-(trifluoromethyl)-1H-pyrazole (93 mg, 0.68 mmol), copper(I) iodide (13 mg, 0.068 mmol), 8-hydroxyquinoline (20 mg, 0.14 mmol), and potassium carbonate (95 mg, 0.68 mmol) in DMSO (2 mL) was stirred at 130 C under N2 atmosphere overnight. The mixture was quenched with saturated aqueous NH4Cl solution and the insoluble materials were removed by filtration. The filtrate was extracted with AcOEt. The organic layer was successively washed with water and brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/AcOEt = 70:30 to 30:70) and crystallized from AcOEt-iPr2O to give the title compound as a pale yellow solid (80 mg, 0.13 mmol, 37%). MS (ESI/APCI) m/z 640.3 [M+H]+. 1H NMR (300 MHz, DMSO-d6) delta 1.96-2.10 (4H, m), 3.20 (2H, t, J = 8.2 Hz), 3.83 (2H, br s), 4.40 (2H, t, J = 8.1 Hz), 7.38-7.47 (2H, m), 7.48-7.57 (2H, m), 8.28 (1H, s), 9.05 (2H, s), 9.18 (1H, s), 10.02 (1H, s). 13C NMR (101 MHz, DMSO-d6) delta 18.0, 27.5, 30.3, 48.4, 52.0, 112.8 (t, J = 16.9 Hz), 113.1-113.4 (m), 113.8 (q, J = 37.4 Hz), 120.2, 122.7 (q, J = 266.3 Hz), 124.1, 125.6, 127.5, 128.9 (q, J = 3.7 Hz), 132.6 (t, J = 13.2 Hz), 134.3, 137.3, 138.5-138.6 (m), 140.7, 149.2, 156.7, 158.9 (dd, J = 253.5, 5.5 Hz), 171.1. Mp 242-245 C. Anal. Calcd for C26H19ClF5N7O3S: C, 48.79; H, 2.99; N, 15.32. Found: C, 48.82; H, 2.92; N, 15.06.

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

Related Products of 52222-73-8, These common heterocyclic compound, 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen-purged glove box, a vial, equipped with a TEFLON coated magnetic stir bar, was charged with (oxybis(2,1-phenylene))bis(diphenylphosphine) (1.00 g, 1.86 mmol) and 4-trifluoromethylpyrazole (0.253 g, 1.86 mmol). Toluene (5 mL) was added, followed by mesitylcopper(I) (0.283 g, 1.55 mmol) dissolved in toluene (5 mL). The resulting yellow solution was stirred at approximately 60C for 15 hours. The mixture was cooled and filtered. The white solid was washed with toluene (5 mL) and hexanes (5 mL), and dried to afford the title compound as a white solid (0.785 g).

Statistics shows that 4-(Trifluoromethyl)-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 52222-73-8.

Reference of 52222-73-8,Some common heterocyclic compound, 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

For the synthesis of the intermediates 1-3.2.1 17 and 1-3.2.118 to the educt 1-3.1.2 with the appropriate amine in MeOH 0.14 eq copper(I)oxide is added (as shown in Table 15).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethyl)-1H-pyrazole, its application will become more common.

Application of 52222-73-8, A common heterocyclic compound, 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-(trifluoromethyl)-1H-pyrazole (OH, 2.5 g, 18.43 mmol) in DMF (50 mL), CS2CO3 (9.0 g, 27.64 mmol) was added followed by 2-bromo-1-(4-fluorophenyl)ethan-1-one (CH, 4.0 g, 18.43 mmol) and the reaction mixture was stirred at RT for 1H. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with ice water and the aqueous layer was extracted with EtOAc. The combined organic layer was dried over anhydrous Na2S04 and concentrated under reduced pressure. The crude compound was purified by silica gel column chromatography (40% EtOAc/hexane) to afford compound OI (3.0 g, 60.0%) as a light yellow solid.1H NMR (400 MHz, DMSO-d6): _ 8.35 (s, 1H), 8.16-8.12 (m, 2H), 7.95 (s, 1H), 7.45 (t, J = 8.8 Hz, 2H), 5.95 (s, 2H); LC-MS: m/z 273.00 [M+H]+.

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-(Trifluoromethyl)-1H-pyrazole

Step B: methyl 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoate An oven-dried and nitrogen-cooled vial was charged with 4-trifluoromethyl pyrazole (77.0 mg, 0.56 mmol), quinolin-8-ol (10 mg, 0.07 mmol), copper (I) iodide (14 mg, 0.073 mmol), and potassium carbonate (140 mg, 1.0 mmol). A solution of methyl 4-(1-(4-bromophenyl)-4-methylpent-1-en-2-yl)benzoate (182.7 mg, 0.489 mmol) in dimethylsulfoxide (2.5 mL) was then added. The vial was capped and evacuated and back-filled with nitrogen four times. The reaction was then heated to 90 C. for 18 hours. The reaction was cooled to room temperature and partitioned between saturated ammonium chloride and ethyl acetate. The aqueous layer was extracted again with ethyl acetate, and the combined organics were dried over magnesium sulfate, filtered, and concentrated. Column chromatography (0-10% ethyl acetate in heptane) provided methyl 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoate (19.8 mg, 9.5%) as an approximate 1:1 mixture of E/Z isomers. 1H NMR (400 MHz, CDCl3, delta): 8.20 (s, 1H), 8.06 (s, 1H), 8.05-8.01 (m, 2H), 7.98-7.93 (m, 2H), 7.91 (s, 1H), 7.83 (s, 1H), 7.71-7.66 (m, 2H), 7.53-7.49 (m, 2H), 7.46-7.42 (m, 2H), 7.41-7.36 (m, 2H), 7.24-7.20 (m, 2H), 7.01-6.96 (m, 2H), 6.78 (s, 1H), 6.49 (s, 1H), 3.92 (s, 3H), 3.90 (s, 3H), 2.62 (d, J=7.2 Hz, 2H), 2.41 (dd, J=7.2, 1.0 Hz, 2H), 1.70-1.48 (m, 2H), 0.90 (d, J=6.6 Hz, 6H), 0.80 (d, J=6.6 Hz, 6H). MS (M+1): 429.3.

According to the analysis of related databases, 52222-73-8, the application of this compound in the production field has become more and more popular.

52222-73-8, The chemical industry reduces the impact on the environment during synthesis 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Step A: 5-nitro-2-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidine To a solution of 2-chloro-5-nitropyrimidine (1.5 g, 9.4 mmol) and 4-(trifluoromethyl)-1H-pyrazole (1.41 g, 10.3 mmol) in acetonitrile (40 mL) was added potassium carbonate (2.60 g, 18.8 mmol). The reaction was heated to 80 C. and stirred overnight. The reaction was concentrated and the residue was diluted with water and extracted with ethyl acetate (2*40 mL). The combined organics were washed with brine, dried over sodium sulfate, filtered, and concentrated. Purification by flash column chromatography gave 5-nitro-2-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidine (1.5 g, 62%) as a yellow solid. 1H NMR (400 MHz, CDCl3, delta): 9.48 (s, 2H), 8.92 (s, 1H), 8.05 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.