Discovery of 5-Amino-1,3-dimethylpyrazole

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1,3-dimethylpyrazole, and friends who are interested can also refer to it.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3524-32-1 name is 5-Amino-1,3-dimethylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 3524-32-1

A) 4-Bromo-1,3-dimethyl-1H-pyrazol-5-amine To a solution of 1,3-dimethyl-1H-pyrazol-5-amine (8.77 g) in ethyl acetate (180 mL), N-bromosuccinimide (14.75 g) was added under ice cooling, and the mixture was stirred at room temperature for 2 hours in a nitrogen atmosphere. The reaction mixture was diluted with a saturated aqueous solution of sodium bicarbonate, followed by extraction with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium bicarbonate and saturated brine and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to obtain the title compound (12.6 g). MS: [M+H]+ 189.9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1,3-dimethylpyrazole, and friends who are interested can also refer to it.

Extracurricular laboratory: Synthetic route of 3112-31-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3112-31-0, other downstream synthetic routes, hurry up and to see.

A common compound: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 3112-31-0

A.5-[(R)-2-Biphenyl-4-yl-1-(1-carboxy-cyclopropylmethyl)-ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid (R7=H)3,5-Pyrazoledicarboxylic acid (35.2 mg, 226 mumol, 1.0 eq.), DIPEA (126 muL) and HATU (85.9 mg, 226 mumol, 1.0 eq.) and DCM (5 mL) were combined and stirred for 5 minutes at room temperature. 1-((R)-2-Amino-3-biphenyl-4-yl-propyl)-cyclopropanecarboxylic acid (86.7 mg, 294 mumol, 2.3 eq,) and DIPEA (0.5 mL) in DCM (5 mL) was added, and the resulting mixture was stirred for 1 hour.The reaction was quenched with saturated aqueous NH4Cl and the product was extracted with DCM, dried and evaporated.The resulting product was combined with AcOH (1.5 mL) and purified with preparative HPLC to yield the title compound (21.4 mg; 93percent purity). MS m/z [M+H]+ calc’d for C24H23N3O5, 434.16; found 433.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3112-31-0, other downstream synthetic routes, hurry up and to see.