Category: pyrazoles-derivatives

Flavor evolution in raw Pu-erh tea during manufacturing using different processing types was written by Su, Dan;Xu, Tengsheng;Li, Yali;Zhou, Hongjie. And the article was included in LWT–Food Science and Technology in 2022.Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine This article mentions the following:

This study aimed to explore the relationship between the processing type and the flavor in raw Pu-erh tea (RPT). Liquid chromatog.-mass, gas chromatog.-mass spectrometry, and multivariate analyses were employed to measure the component of RPT and to determine the changes in the flavor evolution of RPT at processing type. Sensory evaluation indicated that the processing type enhanced the flavor of the RPT. Based on 12 detected taste-active compounds, PCA and heat map anal. showed the average content of 4 catechins (ECG,EGCG, EC, EGC) in RPTs was 132.27 mg/g, which was 21.19 mg/g less than sun-dried tea (SDT). Astringency and bitterness of RPT can be reduced by processing type. A total of 52 volatile compounds were perceived and 4 volatile components were identified as essential compounds related to PLS-DA (VIP >1, P < 0.05), including phytol, linalool, cis-geraniol, and trans-geraniol, which increased from 62.27% in SDT to 66.25% in brick tea, which significantly contributes to the floral flavor of brick tea. The findings presented in this thesis add to our understanding of the relationship between the processing type and the flavor of RPT. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors was written by Das, Jagabandhu;Moquin, Robert V.;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Computed Properties of C5H8N4O This article mentions the following:

The synthesis and structure-activity relationships (SAR) of p38α MAP kinase inhibitors based on a pyrazolo-pyrimidine scaffold are described. These studies led to the identification of compound I as a potent and selective inhibitor of p38α MAP kinase with excellent cellular potency toward the inhibition of TNFα production I was highly efficacious in vivo in inhibiting TNFα production in an acute murine model of TNFα production X-ray co-crystallog. of a pyrazolopyrimidine analog bound to unphosphorylated p38α is also disclosed. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Computed Properties of C5H8N4O).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Computed Properties of C5H8N4O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reaction of β-aminoenones with hydrazine derivatives. Regioselective synthesis of pyrazoles was written by Alberola, A.;Andres, C.;Gonzalez Ortega, A.;Pedrosa, R.;Vicente, M.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1987.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:

The β-aminoenones, obtained by hydrogenation of isoxazoles (Raney Ni W-2), react with hydrazine derivatives giving pyrazoles in excellent yields. The reaction is general and regiospecific, and allows the preparation of pyrazoles with different functionality at C(4). In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Recommanded Product: 3,5-Dimethyl-1H-pyrazole-1-carboxamide

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of Free-Wilson models in spectroscopy. Reevaluation of the Tensmeyer additivity system in the proton NMR of pyrazoles was written by Cativiela, C.;Garcia, J. I.;Elguero, J.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1987.Electric Literature of C11H10N2O2 This article mentions the following:

Modified coefficients of the Tensmeyer additivity system are used to calculate ¹H NMR chem. shifts δ(4-H) of the proton at the 4-position of 1,3,5-substituted pyrazoles. The coefficients were reevaluated by using a more accurate math. procedure. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Electric Literature of C11H10N2O2).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Electric Literature of C11H10N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and fungicidal activity of methyl N-methoxy-N-[2-(3-trifluoromethyl-1-substituted pyrazole-5-yloxymethylene)] phenylcarbamates was written by Liu, Weidong;Li, Jiangsheng;Li, Zhongying;Wang, Xiaoguang;Gao, Bida. And the article was included in Nongyaoxue Xuebao in 2004.Computed Properties of C4H3F3N2O This article mentions the following:

A series of novel Me N-methoxy-N-[2-(3-trifluoromethyl)-1-substituted pyrazole-5-yloxymethylene] phenylcarbamates I (R = Ph, 4-ClPh, 4-FPh, 2-MePh, 2,4-diMePh, 2,4-diClPh, 2-F-4-BrPh, 3,5-DiClPh, 3,4-diClPh, 2,4,5-triClPh, t-Bu, CH₂CO₂Et, Bn) were synthesized from 3-trifluoromethyl-1-substituted pyrazole-5-one and Me N-methoxy-N-(2-bromomethylphenyl) carbamates. All compounds were confirmed by ¹H NMR, IR and LC/MS. The preliminary bioassays showed that some compounds had fungicidal activities to Pyricularia oryzae, Botrytis cinerea, and Erysiphe graminis under 50 mg/L, for example, the inhibitory ratio of compound I (R = Bn) to P. oryzae was 94%. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Computed Properties of C4H3F3N2O).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Computed Properties of C4H3F3N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family was written by Troester, Alix;Heinzlmeir, Stephanie;Berger, Benedict-Tilman;Gande, Santosh L.;Saxena, Krishna;Sreeramulu, Sridhar;Linhard, Verena;Nasiri, Amir H.;Bolte, Michael;Mueller, Susanne;Kuster, Bernhard;Medard, Guillaume;Kudlinzki, Denis;Schwalbe, Harald. And the article was included in ChemMedChem in 2018.Formula: C5H8N4O This article mentions the following:

Erythropoietin-producing hepatocellular (EPH) receptors are transmembrane receptor tyrosine kinases. Their extracellular domains bind specifically to ephrin A/B ligands, and this binding modulates intracellular kinase activity. EPHs are key players in bidirectional intercellular signaling, controlling cell morphol., adhesion, and migration. They are increasingly recognized as cancer drug targets. We analyzed the binding of NVP-BHG712 (NVP) to EPHA2 and EPHB4. Unexpectedly, all tested com. available NVP samples turned out to be a regioisomer (NVPiso) of the inhibitor, initially described in a Novartis patent application. They only differ by the localization of a single Me group on either one of two adjacent nitrogen atoms. The two compounds of identical mass revealed different binding modes. Furthermore, both in vitro and in vivo experiments showed that the isomers differ in their kinase affinity and selectivity. In the experiment, the researchers used many compounds, for example, 5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7Formula: C5H8N4O).

5-Amino-1-methyl-1H-pyrazole-4-carboxamide (cas: 18213-75-7) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Formula: C5H8N4O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

An improved synthesis of 3,6-diamino-1,2,4,5-tetrazine. I was written by Coburn, Michael D.;Ott, Donald G.. And the article was included in Journal of Heterocyclic Chemistry in 1990.Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:

Treatment of 1,3-diaminoguanidine monohydrochloride with 2,4-pentanedione in alcs. under carefully controlled conditions gave the tetrazine monohydrochloride I in 45-50% yields along with 3,5-dimethyl-1H-pyrazole and its hydrochloride. Oxidation of I with sodium perborate produced 3,6-diamino-1,2,4,5-tetrazine (II) in quant. yield. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Penta- and dinuclear carboxylate nickel(II) complexes with pyrazole-based ligands: Syntheses, magnetic properties and DFT calculations was written by Nikiforov, Alexey A.;Dubrov, Evgenii N.;Blinou, Daniil O.;Gurzhiy, Vladislav V.;Selyutin, Artem A.;Klyukin, Ilya N.;Zhdanov, Andrey P.;Minkovich, Alexander E.;Panina, Natalia S.;Eremin, Alexei V.. And the article was included in Polyhedron in 2021.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

<<One pot>> reactions of pyrazole-based ligands Hdmpz and PyPz with in situ formed carboxylate precursors led to the formation of mono- and di-aqua-bridged binuclear compounds, as well as pentanuclear hydroxo-bridged compound: [Ni₂(μ-OH₂)(μ-O₂CC(CH₃)₃)₂(O₂CC(CH₃)₃)₂(PyPz)₂] (1), [Ni₅(μ₃-OH)₂(μ-O₂CPh)₈(PyPz)₄]^.4.73MeCN (2), [Ni₂(μ-OH₂)(μ-O₂CPh)₂(O₂CPh)₂(Hdmpz)₄] (3), [Ni₂(μ-OH₂)₂(μ-O₂CPh)(O₂CPh)₂(Hdmpz)₄](O₂CPh)•2.5H₂O (4) (Hdmpz = 3,5-dimethylpyrazole, PyPz = 2-(5-Methyl-1H-pyrazol-3-yl)pyridine). Compounds were characterized by structural and spectral methods, thermogravimetric anal. and magnetic measurements were also performed. It was noted, that structural motif of forming compounds are determined by the structure of carboxylate precursors formed in situ and properties of N-ligands. Comparison of magnetic measurements data, structural data, and DFT calculations allows us to conclude that in the case of investigated compounds the equilibrium between spin isomers with different multiplicities, close energy values and close geometrical structure (no data) can be realized. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and fungitoxicity of derivatives of thiopyrazolone and their oxidation products was written by Devi, S.;Mitra, P.;Mishra, S. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1983.Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one This article mentions the following:

On treatment with P₂S₅, pyrazolones afford thiopyrazolones which on condensation with 4-monobromo- and dibromopyrazolones in 1:1 and 1:2 ratio, resp., yield mixed bis and tris derivatives, i.e. I and II. The bis compounds of thiopyrazolone were also prepared These compounds with their oxidized derivatives were assayed for antifungal activity against Pyricularia oryzae and Helminthosporium oryzae. Some of the compounds show a very good fungicidal activity and are compared with standard com. fungicides. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of quinazolone and its derivatives as potential fungicides was written by Das, N. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1979.Computed Properties of C4H5BrN2O This article mentions the following:

Condensation of 4-bromo-2-pyrazolin-5-one with 2-mercapto-3-aryl-4-quinazolones afforded quinazolones I (R = aryl,R¹ = H, Ph). They are fungitoxic against the rice blast pathogen Pyricularia oryzae and brown leaf spot pathogen Helminthosporium oryzae. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Computed Properties of C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Computed Properties of C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics